Low organic solvent exposure and combined maternal-infant gene polymorphisms affect gestational age
1 Peking University Health Science Center, China
2 Beijing Yanshan Petrochemical Corporation Staff Hospital, China
* To whom correspondence should be addressed. E-mail: firstname.lastname@example.org .
Accepted 2 November 2007
Objective: Little information is available on the associations of combined maternal-infant genetic susceptibility, environmental exposures, and reproductive outcomes, especially in Chinese population. This study was to investigate whether the polymorphisms of combined maternal-infant metabolic genes, CYP1A1 Hinc¢ò, CYP1A1 Msp¢ñ, GSTT1 and GSTM1 affect the association of maternal organic solvents exposure with gestational age.
Methods: A total of 1,113 mother-infant pairs were enrolled from the Beijing Yanshan Petrochemical Corporation between June 1997 and June 2002, of which 546 mothers were exposed to organic solvents and 567 were not. Multiple linear regression models were used to estimate the combined maternal-infant gene effects, and to characterize combined maternal-infant genetic susceptibility to organic solvents in relation to gestation.
Results: Organic solvents exposure was significantly related to the shortened gestation (-1.2 weeks, 95% CI:-1.6,-0.9). Additionally, combined maternal-infant genotypes including Ile/Ile462-Ile/Ile462 (-0.6 weeks, 95% CI:-0.9,-0.4) in CYP1A1 Hinc¢ò and absent-absent in GSTT1 (-0.4 weeks, 95% CI:-0.9,-0.3) were significantly associated with shorter gestation. When considering both organic solvents exposure and combined maternal-infant genotypes, the largest associations were found among exposed women with absent-absent genotype (-1.5 weeks, 95% CI:-1.8,-1.2) in GSTT1 and Ile/Ile462-Ile/Ile462 genotype (-1.5 weeks, 95% CI:-1.8,-1.2) in CYP1A1 Hinc¢ò, suggesting that combined genotypes would modify the effect of organic solvents exposure on gestation.
Conclusions: This study demonstrates the role of combined maternal-infant genotypes in modifying the adverse effects of organic solvents exposure on gestation, and maternal-infant interaction of the 4 genes was determined.