Sunday, December 23, 2007

Air Pollution and Heart Rate Variability: Effect Modification by Chronic Lead Exposure.

Epidemiology. 2008 Jan;19(1):111-120.Click here to read Links

Air Pollution and Heart Rate Variability: Effect Modification by Chronic Lead Exposure.

From the *Departments of *Environmental Health Sciences and †Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan; ‡VA Normative Aging Study, Veterans Affairs Boston Healthcare System, West Roxbury, Massachusetts; §Department of Medicine, Boston University School of Medicine, Boston, Massachusetts; ¶Channing Laboratory, Department of Medicine, Brigham and Womenʼs Hospital, Harvard Medical School, Boston, Massachusetts; Departments of ∥Environmental Health and **Biostatistics, Harvard School of Public Health, Boston, Massachusetts.

BACKGROUND:: Outdoor air pollution and lead exposure can disturb cardiac autonomic function, but the effects of both these exposures together have not been studied. METHODS:: We examined whether higher cumulative lead exposures, as measured by bone lead, modified cross-sectional associations between air pollution and heart rate variability among 384 elderly men from the Normative Aging Study. We used linear regression, controlling for clinical, demographic, and environmental covariates. RESULTS:: We found graded, significant reductions in both high-frequency and low-frequency powers of heart rate variability in relation to ozone and sulfate across the quartiles of tibia lead. Interquartile range increases in ozone and sulfate were associated respectively, with 38% decrease (95% confidence interval = -54.6% to -14.9%) and 22% decrease (-40.4% to 1.6%) in high frequency, and 38% decrease (-51.9% to -20.4%) and 12% decrease (-28.6% to 9.3%) in low frequency, in the highest quartile of tibia lead after controlling for potential confounders. We observed similar but weaker effect modification by tibia lead adjusted for education and cumulative traffic (residuals of the regression of tibia lead on education and cumulative traffic). Patella lead modified only the ozone effect on heart rate variability. CONCLUSIONS:: People with long-term exposure to higher levels of lead may be more sensitive to cardiac autonomic dysfunction on high air pollution days. Efforts to understand how environmental exposures affect the health of an aging population should consider both current levels of pollution and history of lead exposure as susceptibility factors.

PMID: 18091001 [PubMed - as supplied by publisher]

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