Pollution on Cardiovascular Physiology and Systemic Mediators in Seniors.
J Occup Environ Med. 2009 Aug 20. [Epub ahead of print]
Liu L, Ruddy T, Dalipaj M, Poon R, Szyszkowicz M, You H, Dales RE, Wheeler
From the Healthy Environments and Consumer Safety Branch (Dr Liu, Dr Poon,
Dr Szyszkowicz, Mr You, Dr Dales, Dr Wheeler), Health Canada; and Division
of Cardiology and Division of Nuclear Medicine (Dr Ruddy, Ms Dalipaj),
University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
OBJECTIVE:: To investigate the associations between exposure to particulate
air pollution and changes in cardiovascular function and plasma mediators in
METHODS:: We monitored daily indoor and outdoor black carbon and particulate
matter </=2.5 mum (pm2.5) and personal pm2.5 repeatedly for 28 nonsmoking
seniors. We then measured their blood pressure, heart rate, and brachial
artery function, and determined plasma mediators of inflammation, vascular
function, and oxidative stress. We tested associations using mixed-effects
RESULTS:: Increases in black carbon and pm2.5 were associated with increases
in blood pressure, heart rate, endothelin-1, vascular endothelial growth
factor, and oxidative stress marker thiobarbituric acid reactive substances,
and a decrease in brachial artery diameter (P < 0.05).
CONCLUSION:: Daily exposure to particulate pollution, likely
traffic-related, may result in adverse effects on cardiovascular function
and blood mediators that modulate vascular system in seniors.
PMID: 19701101 [PubMed - as supplied by publisher]