Ascorbic acid combats arsenic-induced oxidative stress in mice liver.

Ecotoxicol Environ Saf. 2008 Aug 18. [Epub ahead of print]

Ascorbic acid combats arsenic-induced oxidative stress in mice liver.

http://www.ncbi.nlm.nih.gov/pubmed/18715643?dopt=AbstractPlus
Banerjee P, Bhattacharyya SS, Bhattacharjee N, Pathak S, Boujedaini N, Belon P, Khuda-Bukhsh AR.

Department of Zoology, University of Kalyani, Kalyani-741235, West Bengal, India.
Repeated injections of arsenic trioxide induced oxidative stress and hepatotoxicity in mice as revealed from elevated levels of glutamate oxaloacetate transaminases, glutamate pyruvate transaminases, acid and alkaline phosphatases, lipid peroxidation along with reduction of superoxide dismutase, catalase, reduced glutathione content, glutathione reductase and succinate dehydrogenase activities. The present investigation was undertaken to test whether simultaneous feeding of Vitamin-C can combat hepatotoxicity in arsenic intoxicated mice. Hepatoprotective potential of Vitamin-C was indicated by its ability to restore GSH, SOD, CAT, AcP, AlkP and GRD levels towards near normal. Electron microscopic studies further supported the biochemical findings confirming the hepatoprotective potential of ascorbic acid. Besides, cytogenetical endpoints (chromosome aberrations, micronuclei, mitotic index and sperm head anomaly) were also analyzed. Administration of Vitamin-C alone did not show any sign of toxicity of its own. Based on the present findings, ascorbic acid appears to have protective effects against arsenic toxicity and oxidative stress.

PMID: 18715643 [PubMed - as supplied by publisher]

Key Words: multiple chemical sensitivity, chemical sensitivity, chemical sensitivities, multiple chemical sensitivities, MCS, EI, environmental illness, sick building syndrome, idiopathic environmental intolerance, fibromyalgia, chronic fatiuge, FM, CFS, mold illness, clinical ecology, alternative medicine, environmental medicine, neuropathy, encephalopathy, toxic, chemical