Knut-Arne Wensaas,1,2 Nina Langeland,3 Kurt Hanevik,3,4 Kristine Mørch,4,5
Geir Egil Eide,1,6 Guri Rortveit1,2
Background Giardia lamblia is a common cause of gastroenteritis worldwide, but there is limited knowledge
about the long-term complications.
and 1128 matched controls.
the adjusted RR¼3.4 (95% CI 2.9 to 3.8). Chronic fatigue was reported by 46.1% of the exposed group and 12.0%
of the controls, the adjusted RR was 4.0 (95% CI 3.5 to 4.5). IBS and chronic fatigue were associated and the RR
for the exposed group of having a combination of the two outcomes was 6.8 (95% CI 5.3 to 8.5). The RR was
also increased for having just one of the two syndromes, 1.8 for IBS (95% CI 1.4 to 2.3) and 2.2 for chronic fatigue
(95% CI 1.7 to 2.8).
prevalence of IBS and chronic fatigue 3 years after acute illness, and the risk was significantly higher than in the
control group. This shows that the potential consequences of giardiasis are more serious than previously known. Further studies are needed, especially in areas where giardiasis is endemic.