Purine metabolites in fibromyalgia syndrome.
http://www.ncbi.nlm.nih.gov/pubmed/23000315
http://www.ncbi.nlm.nih.gov/pubmed/23000315
Fais A, Cacace E, Corda M, Era B, Peri M, Utzeri S, Ruggiero V.
Clin Biochem. 2012 Sep 18. pii: S0009-9120(12)00539-5. doi: 10.1016/j.clinbiochem.2012.09.009. [Epub ahead of print]
Source
Dipartimento di Scienze della Vita e dell'Ambiente, Università di Cagliari, 09042 Monserrato, Cagliari, Italy.
Source
Dipartimento di Scienze della Vita e dell'Ambiente, Università di Cagliari, 09042 Monserrato, Cagliari, Italy.
Abstract
OBJECTIVE:
To evaluate serum purine metabolite concentrations in patients affected by fibromyalgia syndrome (FMS) and the relationships between their levels and FM clinical parameters.
To evaluate serum purine metabolite concentrations in patients affected by fibromyalgia syndrome (FMS) and the relationships between their levels and FM clinical parameters.
DESIGN AND METHODS:
Serum purine levels were quantified using LC/UV-vis in 22 fibromyalgic females (according to the American College of Rheumatology classification criteria) and 22 healthy females.
Serum purine levels were quantified using LC/UV-vis in 22 fibromyalgic females (according to the American College of Rheumatology classification criteria) and 22 healthy females.
RESULTS:
Significantly higher serum inosine, hypoxanthine and xanthine levels (p<0.001) and significantly lower serum adenosine (p<0.05) were detected in the FMS patients vs healthy controls. Our data show a negative correlation between adenosine and Fibromyalgia Impact Questionnaire (FIQ).
Significantly higher serum inosine, hypoxanthine and xanthine levels (p<0.001) and significantly lower serum adenosine (p<0.05) were detected in the FMS patients vs healthy controls. Our data show a negative correlation between adenosine and Fibromyalgia Impact Questionnaire (FIQ).
CONCLUSIONS:
Study results suggest that purines, in particular adenosine and inosine, may be involved in pain transmission in fibromyalgia.
PMID: 23000315 [PubMed - as supplied by publisher]
Study results suggest that purines, in particular adenosine and inosine, may be involved in pain transmission in fibromyalgia.
PMID: 23000315 [PubMed - as supplied by publisher]
