Patel, M. et. al.
Available online 23 November 2012. In Press.
Exposures to ambient diesel exhaust particles have been associated with respiratory symptoms and asthma exacerbations in children; however, epidemiologic evidence linking short-term exposure to ambient diesel exhaust particles with airway inflammation is limited. We conducted a panel study with asthmatic and nonasthmatic adolescents to characterize associations between ambient diesel exhaust particle exposures and exhaled biological markers of airway inflammation and oxidative stress.
► We measured airway inflammation in urban youth with and without asthma for 4 weeks. ► We measured daily ambient air black carbon as an indicator of diesel air pollution. ► Black carbon was associated with airway inflammation and oxidative stress over time. ► Ambient air nitrogen dioxide was associated with airway oxidative stress over time. ► Traffic emissions may increase airway inflammation in youth with and without asthma.