Effects of air pollution on neonatal prematurity in Guangzhou of China, a time-series study
http://www.ehjournal.net/content/10/1/2/abstract
http://www.ehjournal.net/content/10/1/2/abstract
Qingguo Zhao , Zhijiang Liang , Shijuan Tao , Juan Zhu and Yukai Du
Environmental Health 2011, 10:2doi:10.1186/1476-069X-10-2
Published:10 January 2011
Abstract (provisional)
Background
Over the last decade, a few of studies have investigated the possible adverse effects of ambient air pollution on preterm birth. But the evidence and conclusion as yet are still unconvincing.
Over the last decade, a few of studies have investigated the possible adverse effects of ambient air pollution on preterm birth. But the evidence and conclusion as yet are still unconvincing.
Methods
The relationship between air pollution and preterm rate in Guangzhou city was examined by the Generalized Additive Model (GAM) extended Poisson regression model in which we controlled the confounding factors such as meteorological factors, time trends, weather and day of the week (DOW) as well as adjusted co-linearity of air pollutants by Principal Component Analysis. The meteorological data and air pollution data were from the Meteorological Bureau and the Environmental Monitoring Station while the medical record of newborns were collected from the perinatal health database of all obstetric institutions in Guangzhou, China in 2007.
Results
The average daily concentration of NO2, PM10, SO2 in Guangzhou,China in 2007 were 61.04, 82.51 and 51.67mug/m3,respectively; the average number of preterm babies born in 2007 were 21.47/day. Pearson correlation analysis suggested a negative correlation between the concentration of NO2, PM10, SO2 and temperature and relative humidity. As for the time-series GAM analysis, the results of single air pollutant model suggested that the cumulative effects of NO2, PM10, SO2 reached their maximum on day 3, day 4, day 3 respectively. An increase of 100ug/m3 of air pollutants corresponded to RR as 1.054295CI: 1.0080 ~1.1003, 1.068895CI: 1.0074 ~1.1301, 1.129895CI: 1.0480 ~1.2116respectively. After adjusted collinearity by the Principal Component Analysis, the GAM model of the three air pollutants suggested that an increase of 100ug/m3 of air pollutants corresponded to RR as 1.018595%CI: 1.0056~1.0313, 1.021595%CI: 1.0066 ~1.0365, 1.032695%CI: 1.0101 ~1.0552on day 0 , and RR of the strongest cumulative effects of the three air pollutants was interpreted as 1.021995%CI: 1.0053~1.0386, 1.027495%CI: 1.0066~1.0482, 1.038895%CI: 1.0096 ~1.0681respectively.
Conclusions
There is evidence showing that daily concentration of NO2, PM10, SO2 was positively associated with the preterm rate in Guangzhou, China.
