Proteinopathy Induced Neuronal Senescence: A Hypothesis for Brain Failure in Alzheimer's and other Neurodegenerative Diseases

Proteinopathy Induced Neuronal Senescence: A Hypothesis for Brain Failure in Alzheimer's and other Neurodegenerative Diseases
http://7thspace.com/headlines/322611/proteinopathy_induced_neuronal_senescence_a_hypothesis_for_brain_failure_in_alzheimers_and_other_neurodegenerative_diseases.html

"Alzheimer's disease (AD) and a host of other neurodegenerative central nervous system (CNS) proteinopathies are characterized by the accumulation of misfolded protein aggregates. Simplistically, these aggregates can be divided into smaller, soluble, oligomeric and larger, less-soluble or insoluble, fibrillar forms.  Perhaps the major ongoing debate in the neurodegenerative disease field is whether the smaller oligomeric or larger fibrillar aggregates are the primary neurotoxin. Herein, we propose an integrative hypothesis that provides new insights into how a variety of misfolded protein aggregates can result in neurodegeneration."