BACKGROUND: Limited human data suggests an association of organochlorine pesticides (OCPs) with adverse effects on children's growth.
OBJECTIVE: To evaluate the associations of OCPs with longitudinally-assessed growth among peri-pubertal boys from a Russian cohort with high environmental OCP levels.
METHODS: A cohort of 499 boys enrolled in the Russian Children's Study between 2003 and 2005 at ages 8-9 years were followed prospectively for four years. At study entry, 350 boys had serum OCPs measured. Physical examinations were conducted at entry and annually. The longitudinal associations of serum OCPs with annual measurements of body mass index (BMI), height, and height velocity were examined by multivariate mixed effects regression models for repeated measures, controlling for potential confounders.
CONCLUSIONS: Serum OCP concentrations measured at age 8 to 9 years were associated with reduced growth, particularly reduced BMI, during the peri-pubertal period, which may impact attainment of optimal adult body mass and height.