Modulation of antigen-induced chronic fatigue in mouse model of water
immersion stress by naringin, a polyphenolic antioxidant.
Journal: Fundam Clin Pharmacol. 2009 Mar 10. [Epub ahead of print]
Authors: Vij G, Gupta A, Chopra K.
Affiliation: Pharmacology Division, University Institute of
Pharmaceutical Sciences, Punjab University, Chandigarh - 160014, India.
NLM Citation: PMID: 19469804
'
Abstract
It is believed that physical stress, infection and oxidative stress
are involved in the development of chronic fatigue syndrome. There is
little evidence stating the beneficial role of nutritional
supplements in chronic fatigue syndrome. Based on this, this study
was designed to evaluate the effect of naringin, a natural
polyphenol, in a mouse model of immunologically-induced fatigue,
wherein purified lipopolysaccharide (LPS) as well as Brucella abortus
(BA) antigen was used as immunogens.
The assessment of chronic fatigue syndrome was based on chronic
water-immersion stress test for 10 mins as well as measurement of
hyperalgesia for 19 days. Immobility time and tail withdrawal latency
as well as oxidative stress were taken as the markers of fatigue.
Mice challenged with LPS or BA for 19 days showed significant
increase in the immobility time, hyperalgesia and oxidative stress on
19th day. Serum tumor necrosis factor-alpha (TNF-alpha) levels
markedly increased with LPS or BA challenge. Concurrent treatment
with naringin resulted in the significant decrease in the immobility
time as well as hyperalgesia. There was significant attenuation of
oxidative stress as well as in TNF-alpha levels.
Present findings strongly suggest the role of oxidative stress and
immunological activation in the pathophysiology of chronic fatigue
syndrome, and treatment with naringin can be a valuable option in
chronic fatigue syndrome.
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