A group of 42 healthy volunteers underwent 4 weeks of green tea polyphenol intervention. A standardized Polyphenon E preparation was taken each day at a dose that contains 800 mg epigallocatechin gallate. The GST activity in blood lymphocytes from was enhanced, providing beneficial detoxifying enzymes to the subjects. Further, the enhancement was statistically significant.
Chow and colleagues concluded that 4 weeks of Polyphenon E had differential effects on GST activity. The level increased significantly in individuals with low baseline enzyme activity/level. This could hold some promise, not only for healthy subjects, but also for multiple chemical sensitivity MCS patients for the purpose of increasing glutathione for purposes of detoxification and body burden reduction. As many MCS patients and practitioners are searching for ways to increase glutathione, this finding may prove useful in therapy.
It is already known that green tea is an antioxidant and that it helps protect against cancer, and now it has been shown to increase the production of glutathione S-transferases, which are detoxifiers. Perhaps a cup of green tea a day is just what the doctor ordered!
Chow HH, Hakim IA, Vining DR, Crowell JA, Tome ME, Ranger-Moore J, Cordova CA, Mikhael DM, Briehl MM, Alberts DS. Modulation of human glutathione s-transferases by polyphenon e intervention. Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1662-6.