Ferreira JD, Couto AC, Pombo-de-Oliveira MS, Koifman S, and the Brazilian Collaborative Study Group of Infant Acute Leukemia. In Utero Pesticide Exposure and Leukemia in Brazilian Children < 2 Years of Age Environ Health Perspect (): .doi:10.1289/ehp.1103942
Background: An association between pesticides exposure and cancer has been suggested. Infant leukemia is a rare neoplasm and its association with maternal pesticide exposure has been poorly explored.
Results: Associations with ever use of pesticides during pregnancy were observed for acute lymphoblastic leukemia, ALL (adj. OR 2.10; 95% CI: 1.14, 3.86) and acute myeloid leukemia, AML (adj. OR 5.01; 95% CI: 1.97, 12.7) in children age 011 months, and with ALL (adj. OR 1.88; 95% CI: 1.05, 5.23) at age 12-23 months. According to reported maternal exposure to permethrin, higher risk estimates were verified for children 0-11 months, adj. OR 2.47; 95% CI: 1.17, 5.25 for ALL, and adj. OR 7.28; 95% CI: 2.60, 20.38 for AML. Maternal pesticide exposure related to agricultural activities showed an adj. OR 5.25; 95% CI: 1.83, 15.08 for ALL, and an adj. OR 7.56; 95% CI: 1.83, 31.23 for AML.