Nitric oxide level in the nasal and sinus mucosa after exposure to
electromagnetic field.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=15886623&query_hl=1&itool=pubmed_docsum
Yariktas M, Doner F, Ozguner F, Gokalp O, Dogru H, Delibas N.
Department of Otolaryngology, Suleyman Demirel University School of
Medicine, 32100 Isparta,
Turkey. myariktas@hotmail.com
OBJECTIVE: The purpose of this study was to examine the changes in nitric
oxide (NO) level in
the nasal and paranasal sinus mucosa after exposure radiofrequency
electromagnetic fields (EMF).
STUDY DESIGN AND SETTING: Thirty male SpragueDawley
rats were randomly grouped as
follows: EMF group (group I; n, 10), EMF group in which melatonin received
(group II; n, 10) and
the control (sham operated) group (group III; n, 10). Groups I and II were
exposed to a 900 MHz.
Oral melatonin was given in group II. Control rats (group III) were also
placed in the tube as the
exposure groups, but without exposure to EMF. At the end of 2 weeks, the
rats were sacrificed, and
the nasal and paranasal sinus mucosa dissected. NO was measured in nasal and
paranasal mucosa.
RESULTS: The nasal and paranasal sinus mucosa NO levels of group I were
significantly higher
than those of the control group (group III) ( P < 0.05). However, there was
no statistically
significant difference between group II and the control group (group III)
regarding NO output ( P >
0.05).
CONCLUSION: Exposure to EMF released by mobile phones (900 MHz) increase NO
levels in the
sinus and nasal mucosa.
SIGNIFICANCE: Increased NO levels may act as a defense mechanism and
presumably related to
tissue damage. In addition, melatonin may have beneficial effect to prevent
these changes in the
mucosa.
PMID: 15886623 [PubMed indexed
for MEDLINE]
