Group Wants Edina Bonfires Banned Due to Health Concerns
VIDEO: http://kstp.com/news/stories/s2781517.shtml
VIDEO: http://kstp.com/news/stories/s2781517.shtml
Sunday, September 30, 2012
A Tribute To Rich Van Konynenburg
"Long time chronic fatigue syndrome supporter and theorist, Rich Van Konynenburg died last night in his sleep. His wife Diana reported"
Exposure to herbicide may increase risk of rare disorder
"A common herbicide used in the United States may be linked to an increased risk of a congenital abnormality of the nasal cavity known as choanal atresia, say researchers at Baylor College of Medicine and other Texas institutions."
Book Review: 'Full Body Burden' by Kristen Iversen
Book Review: 'Full Body Burden' by Kristen Iversen
http://www.nytimes.com/2012/09/28/books/book-review-full-body-burden-by-kristen-iversen.html?_r=1
"Like prison wardens and World Cup goalkeepers, book critics toss and turn over the ones that got away. The books they should have pounced upon, that is, but did not. One such book, people have been telling me, is "Full Body Burden: Growing Up in the Nuclear Shadow of Rocky Flats," by Kristen Iversen. Ms. Iversen's book was issued back in June. I'm getting to it now because I couldn't shoulder the guilt — my hard-to-please wife is among its importuning admirers — for another day. Ms. Iversen grew up in the 1960s and '70s in the small town of Arvada, Colo., about 10 miles from Denver, where most of the fathers worked at one of two nearby factories. The first belonged to Coors, whose weak brew was derided as "Colorado Kool-Aid." More mysterious, and thus prestigious, employment was found at Rocky Flats, a secret nuclear plant where employees made the plutonium warhead triggers for America's cold war nuclear arsenal."
http://www.nytimes.com/2012/09/28/books/book-review-full-body-burden-by-kristen-iversen.html?_r=1
"Like prison wardens and World Cup goalkeepers, book critics toss and turn over the ones that got away. The books they should have pounced upon, that is, but did not. One such book, people have been telling me, is "Full Body Burden: Growing Up in the Nuclear Shadow of Rocky Flats," by Kristen Iversen. Ms. Iversen's book was issued back in June. I'm getting to it now because I couldn't shoulder the guilt — my hard-to-please wife is among its importuning admirers — for another day. Ms. Iversen grew up in the 1960s and '70s in the small town of Arvada, Colo., about 10 miles from Denver, where most of the fathers worked at one of two nearby factories. The first belonged to Coors, whose weak brew was derided as "Colorado Kool-Aid." More mysterious, and thus prestigious, employment was found at Rocky Flats, a secret nuclear plant where employees made the plutonium warhead triggers for America's cold war nuclear arsenal."
Rachel Carson: The woman who shaped the environmental debate
Rachel Carson: The woman who shaped the environmental debate
http://www.thestar.com/news/insight/article/1264209--rachel-carson-the-woman-who-shaped-the-environmental-debate
"Hailed during the war years as the miracle that saved troops from typhus and malaria, DDT was sprayed on crops, forests, cities, even people — and was found in hundreds of consumer products, including supposed ant-repelling kitchen shelf paper. It was everywhere, including where it should not have been. But then, the fish and birds started to die off. And that was just the beginning. To Carson, a biologist, "man's assaults upon the environment," whether through pesticide pollution or nuclear testing fallout, was the "chain of evil.""
http://www.thestar.com/news/insight/article/1264209--rachel-carson-the-woman-who-shaped-the-environmental-debate
"Hailed during the war years as the miracle that saved troops from typhus and malaria, DDT was sprayed on crops, forests, cities, even people — and was found in hundreds of consumer products, including supposed ant-repelling kitchen shelf paper. It was everywhere, including where it should not have been. But then, the fish and birds started to die off. And that was just the beginning. To Carson, a biologist, "man's assaults upon the environment," whether through pesticide pollution or nuclear testing fallout, was the "chain of evil.""
Michelle Obama: Tell Barack to honor his campaign promise to label GMOs
Michelle Obama: Tell Barack to honor his campaign promise to label GMOs
http://signon.org/sign/michelle-obama-tell-presiden?source=c.url&r_by=5382364
"To be delivered to: Michelle Obama, First Lady:
Michelle, tell President Obama to honor his campaign promise to require GMO labeling and ask him to endorse California's Proposition 37, a citizens' ballot initiative to label GMOs."
http://signon.org/sign/michelle-obama-tell-presiden?source=c.url&r_by=5382364
"To be delivered to: Michelle Obama, First Lady:
Michelle, tell President Obama to honor his campaign promise to require GMO labeling and ask him to endorse California's Proposition 37, a citizens' ballot initiative to label GMOs."
Are GMOs on the White House Menu?
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Monday, September 24, 2012
MCS/CFS Survey Deadline October 1st!
The deadline to participate in the MCS/CFS Survey is October 1st. Please respond now!
This survey is integral research looking for biological correlations between MCS, CFS, and diabetes. The results will help physicians and scientists better understand the nature of these conditions and hopefully lead to their prevention and treatment. The results will be published in a peer-review journal, as well as the MCS America News.
Harold Zeliger, the primary researcher, is a chemical toxicologist who has been studying the consequences of chemical combinations on human health. Dr. Zeliger wrote the book "Human Toxicology of Chemical Mixtures". More information about Zeliger can be found on his website at http://www.zeliger.com/.
Please take a moment to answer this short 5 question survey, which can be accessed here: http://www.surveymonkey.com/s/CPTJZM2
If you have already responded, please share with your email list and networks and encourage others to respond.
Sunday, September 23, 2012
Decades later, PBB contamination suspected in illnesses and deaths
Decades later, PBB contamination suspected in illnesses and deaths
http://www.freep.com/article/20120923/NEWS06/309230153/Decades-later-PBB-contamination-suspected-illnesses-deaths
http://www.freep.com/article/20120923/NEWS06/309230153/Decades-later-PBB-contamination-suspected-illnesses-deaths
"Lori Morris doesn't have a thyroid; her sister's esophagus was removed years ago. Three out of four of Hilda Green's grown children are gone, each plagued with health problems and one dead at 50 of leukemia. Jim Buchanan has a litany of health problems that began in his early 30s -- arthritis, gout, irregular heartbeats. Diabetes claimed his daughter at 24. At 63, he's waiting for a heart transplant. They don't know one another. They live in different parts of the state. But each suspects the same three-letter toxin: PBB. "I know there's not proof or nothing, and maybe there never will be," said Morris, 55, a Garden City resident who works in sales. Her thyroid, doctors told her, was gone by the time she was 18. "But we were healthy -- perfectly healthy -- until that PBB mess." It has been four decades since one of the most catastrophic agricultural disasters in U.S. history unfolded in the heart of Michigan, forcing the destruction of tens of thousands of cattle contaminated with polybrominated biphenyl, or PBB, and allowing the chemical to slip onto the dinner plates and into the drinking glasses of nine out of 10 Michiganders."
Information from the Michigan Department of Health on what PBB is and how it got into the feed:
http://www.michigan.gov/documents/mdch_PBB_FAQ_92051_7.pdf
What happened in Michigan in 1973?
"In early 1973, both PBB (sold under the trade name FireMaster) and magnesium oxide (a cattle feed supplement sold under the trade name NutriMaster) were produced at the same St. Louis, Michigan plant by the Michigan Chemical Company. A shortage of preprinted paper bag containers led to 10 to 20 fiftypound bags of PBB accidentally being sent to Michigan Farm Bureau Services in place of NutriMaster. This accident was not recognized until long after the bags had been shipped to feed mills and used in the production of feed for dairy cattle. By the time the mix-up was discovered in April 1974, PBB had entered the food chain through milk and other dairy products, beef products, and contaminated swine, sheep, chickens and eggs. As a result of this incident, over 500 contaminated Michigan farms were quarantined, and approximately 30,000 cattle, 4,500 swine, 1,500 sheep, and 1.5 million chickens were destroyed, along with over 800 tons of animal feed, 18,000 pounds of cheese, 2,500 pounds of butter, 5 million eggs, and 34,000 pounds of dried milk products."
What happened in Michigan in 1973?
"In early 1973, both PBB (sold under the trade name FireMaster) and magnesium oxide (a cattle feed supplement sold under the trade name NutriMaster) were produced at the same St. Louis, Michigan plant by the Michigan Chemical Company. A shortage of preprinted paper bag containers led to 10 to 20 fiftypound bags of PBB accidentally being sent to Michigan Farm Bureau Services in place of NutriMaster. This accident was not recognized until long after the bags had been shipped to feed mills and used in the production of feed for dairy cattle. By the time the mix-up was discovered in April 1974, PBB had entered the food chain through milk and other dairy products, beef products, and contaminated swine, sheep, chickens and eggs. As a result of this incident, over 500 contaminated Michigan farms were quarantined, and approximately 30,000 cattle, 4,500 swine, 1,500 sheep, and 1.5 million chickens were destroyed, along with over 800 tons of animal feed, 18,000 pounds of cheese, 2,500 pounds of butter, 5 million eggs, and 34,000 pounds of dried milk products."
Saturday, September 22, 2012
Mom fights to ban toxins in school supplies
Mom fights to ban toxins in school supplies
http://shine.yahoo.com/healthy-living/mom-fights-to-ban-toxins-in-school-supplies.html
"A recent study has found high levels of toxic chemicals in children's school supplies -- levels so high that, if they were toys instead of backpacks, lunchboxes, and raincoats, they'd be banned by the U.S. government. And one Massachusetts mom is fighting back with a petition to make these products safer."
http://shine.yahoo.com/healthy-living/mom-fights-to-ban-toxins-in-school-supplies.html
"A recent study has found high levels of toxic chemicals in children's school supplies -- levels so high that, if they were toys instead of backpacks, lunchboxes, and raincoats, they'd be banned by the U.S. government. And one Massachusetts mom is fighting back with a petition to make these products safer."
Friday, September 21, 2012
Denmark Intends to Create Database of Products Containing Nanomaterials
Denmark Intends to Create Database of Products Containing Nanomaterials
http://nanotech.lawbc.com/2012/09/articles/international/denmark-intends-to-create-database-of-products-containing-nanomaterials/
"Under a draft amendment to the Danish Chemicals Act, the Minister of the Environment would have the authority to write a detailed order establishing the rules for a national database of mixtures and articles containing or releasing nanomaterials. The order would also require producers and importers to report products containing or releasing nanomaterials. The information in the database is intended to form the basis of an evaluation of whether the content of nanomaterials in products on the Danish market poses a risk for consumers and the environment. The Ministry plans for the first reports to be due in early 2014."
http://nanotech.lawbc.com/2012/09/articles/international/denmark-intends-to-create-database-of-products-containing-nanomaterials/
"Under a draft amendment to the Danish Chemicals Act, the Minister of the Environment would have the authority to write a detailed order establishing the rules for a national database of mixtures and articles containing or releasing nanomaterials. The order would also require producers and importers to report products containing or releasing nanomaterials. The information in the database is intended to form the basis of an evaluation of whether the content of nanomaterials in products on the Danish market poses a risk for consumers and the environment. The Ministry plans for the first reports to be due in early 2014."
Kids exposed to mercury or lead more likely to have ADHD symptoms, Canadian study finds
Kids exposed to mercury or lead more likely to have ADHD symptoms, Canadian study finds
http://www.environmentalhealthnews.org/ehs/news/2012/adhd-lead-and-mercury
"Children exposed to higher levels of mercury or lead are three to five times more likely to be identified by teachers as having problems associated with Attention Deficit Hyperactivity Disorder, according to a scientific study published today. The study, of Inuit children living in Arctic Canada, is the first to find a high rate of attention-deficit symptoms in children highly exposed to mercury in the womb. In addition, the Inuit children more often had hyperactivity symptoms if they were exposed to the same low levels of lead commonly found in young U.S. children. Laval University scientist Gina Muckle said the findings are important because they show for the first time that the effects of mercury in children are not just subtle, but are actually noticeable to teachers. They "may be clinically significant and may interfere with learning and performance in the classroom," the study says. For lead, the school teachers reported much more frequent ADHD symptoms at levels far below the CDC's newly developed health guideline. Dr. Bruce Lanphear, of Simon Fraser University in Vancouver, said evidence is mounting that toxic compounds are "shifting children's behavior...There seem to be a whole host of different toxicants that are associated with ADHD." One of the most intriguing findings was that mercury was linked to attention deficits while lead was associated with hyperactivity. The difference may be the timing of the exposures: in the womb for mercury and during childhood for lead. The findings "suggest the brain may be sensitive to different environmental chemicals at different times in development," said Harvard epidemiologist Joe Braun."
http://www.environmentalhealthnews.org/ehs/news/2012/adhd-lead-and-mercury
"Children exposed to higher levels of mercury or lead are three to five times more likely to be identified by teachers as having problems associated with Attention Deficit Hyperactivity Disorder, according to a scientific study published today. The study, of Inuit children living in Arctic Canada, is the first to find a high rate of attention-deficit symptoms in children highly exposed to mercury in the womb. In addition, the Inuit children more often had hyperactivity symptoms if they were exposed to the same low levels of lead commonly found in young U.S. children. Laval University scientist Gina Muckle said the findings are important because they show for the first time that the effects of mercury in children are not just subtle, but are actually noticeable to teachers. They "may be clinically significant and may interfere with learning and performance in the classroom," the study says. For lead, the school teachers reported much more frequent ADHD symptoms at levels far below the CDC's newly developed health guideline. Dr. Bruce Lanphear, of Simon Fraser University in Vancouver, said evidence is mounting that toxic compounds are "shifting children's behavior...There seem to be a whole host of different toxicants that are associated with ADHD." One of the most intriguing findings was that mercury was linked to attention deficits while lead was associated with hyperactivity. The difference may be the timing of the exposures: in the womb for mercury and during childhood for lead. The findings "suggest the brain may be sensitive to different environmental chemicals at different times in development," said Harvard epidemiologist Joe Braun."
Is your smartphone damaging your health?
Is your smartphone damaging your health?
http://www.theecologist.org/News/news_analysis/1596133/is_your_smartphone_damaging_your_health.html
"Behind the profit-fuelled rise of smartphones and tablets, microwave pollution is a serious assault on health. Known for their beauty, aspens have been in decline across North America, with some dramatic losses in recent years. Aware of the rapid growth of radiofrequency (RF) radiation, particularly from mobile-phone 'towers', Colorado researcher Katie Haggerty had an inspiration: she planted three test plots of aspen seedlings. Carefully matched in all other respects, one plot was shielded from a nearby town's RF radiation, one was 'mock' shielded, and the other was left unprotected. The difference, recorded in the International Journal of Forestry Research, was startling: the fully shielded saplings were vigorous and healthy, but both the 'mock' shielded and the exposed plants were small, lacked pigments, and had sickly leaves."
http://www.theecologist.org/News/news_analysis/1596133/is_your_smartphone_damaging_your_health.html
"Behind the profit-fuelled rise of smartphones and tablets, microwave pollution is a serious assault on health. Known for their beauty, aspens have been in decline across North America, with some dramatic losses in recent years. Aware of the rapid growth of radiofrequency (RF) radiation, particularly from mobile-phone 'towers', Colorado researcher Katie Haggerty had an inspiration: she planted three test plots of aspen seedlings. Carefully matched in all other respects, one plot was shielded from a nearby town's RF radiation, one was 'mock' shielded, and the other was left unprotected. The difference, recorded in the International Journal of Forestry Research, was startling: the fully shielded saplings were vigorous and healthy, but both the 'mock' shielded and the exposed plants were small, lacked pigments, and had sickly leaves."
C-reactive protein and nitric oxide levels in ischemic stroke and its subtypes: correlation with clinical outcome.
C-reactive protein and nitric oxide levels in ischemic stroke and its subtypes: correlation with clinical outcome.
http://www.ncbi.nlm.nih.gov/pubmed/22038116
http://www.ncbi.nlm.nih.gov/pubmed/22038116
Rajeshwar K, Kaul S, Al-Hazzani A, Babu MS, Balakrishna N, Sharma V, Jyothy A, Munshi A.
Inflammation. 2012 Jun;35(3):978-84.
Source
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, India.
Source
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, India.
Abstract
Studies in different populations have shown that ischemic stroke can trigger an acute phase response resulting in a rise of plasma concentration of C-reactive protein (CRP). However, there are very limited studies on CRP and first ischemic stroke divided into subtypes. High levels of CRP may also be associated with poor outcome. The present study was taken up to investigate the prognostic value of CRP within 24 h of onset of ischemic stroke. Five hundred and eighty one patients with first stroke and 575 age- and sex-matched healthy controls were involved in the study. High-sensitivity C-reactive protein (hsCRP) levels were estimated, and follow-up interviews were conducted with patients at 3, 6, and 12 months post-event to determine stroke outcome. In addition to this plasma, NO( x ) (nitrate and nitrite) was measured to detect the serum NO (an important biomarker of inflammation and oxidative stress) levels in ischemic stroke patients and controls. The relationship between CRP value and poor outcome (>2 on modified Rankin Scale Score and <5 on an extended Glasgow outcome scale) was studied. There was a significant association between elevated levels of CRP and NO with the disease. A stepwise multiple logistic regression analysis confirmed these findings after adjustment for potential confounders [adjusted odds ratio = 2.890, 95% CI (1.603-5.011) with p < 0.01 and adjusted odds ratio = 2.364, 95% CI (1.312-3.998) with p < 0.01 for hsCRP and NO, respectively]. After adjustment of potential confounders, patients with high CRP levels had a significant increased risk of poor outcome [adjusted odds ratio = 3.50, 95% CI (1.312-6.365) and p < 0.001]. Elevated levels of hsCRP associated significantly with all stroke subtypes classified according to Trial of ORG 10172 in Acute Stroke Treatment classification except for lacunar stroke and stroke of other determined etiology. In conclusion, hsCRP and NO levels predict the incidence of ischemic stroke and hsCRP is an independent prognostic factor of poor outcome at 3 months.
Studies in different populations have shown that ischemic stroke can trigger an acute phase response resulting in a rise of plasma concentration of C-reactive protein (CRP). However, there are very limited studies on CRP and first ischemic stroke divided into subtypes. High levels of CRP may also be associated with poor outcome. The present study was taken up to investigate the prognostic value of CRP within 24 h of onset of ischemic stroke. Five hundred and eighty one patients with first stroke and 575 age- and sex-matched healthy controls were involved in the study. High-sensitivity C-reactive protein (hsCRP) levels were estimated, and follow-up interviews were conducted with patients at 3, 6, and 12 months post-event to determine stroke outcome. In addition to this plasma, NO( x ) (nitrate and nitrite) was measured to detect the serum NO (an important biomarker of inflammation and oxidative stress) levels in ischemic stroke patients and controls. The relationship between CRP value and poor outcome (>2 on modified Rankin Scale Score and <5 on an extended Glasgow outcome scale) was studied. There was a significant association between elevated levels of CRP and NO with the disease. A stepwise multiple logistic regression analysis confirmed these findings after adjustment for potential confounders [adjusted odds ratio = 2.890, 95% CI (1.603-5.011) with p < 0.01 and adjusted odds ratio = 2.364, 95% CI (1.312-3.998) with p < 0.01 for hsCRP and NO, respectively]. After adjustment of potential confounders, patients with high CRP levels had a significant increased risk of poor outcome [adjusted odds ratio = 3.50, 95% CI (1.312-6.365) and p < 0.001]. Elevated levels of hsCRP associated significantly with all stroke subtypes classified according to Trial of ORG 10172 in Acute Stroke Treatment classification except for lacunar stroke and stroke of other determined etiology. In conclusion, hsCRP and NO levels predict the incidence of ischemic stroke and hsCRP is an independent prognostic factor of poor outcome at 3 months.
PMID: 22038116 [PubMed - indexed for MEDLINE]
Thursday, September 20, 2012
U.N.: Chemicals damaging health and environment
U.N.: Chemicals damaging health and environment
http://www.usatoday.com/news/health/story/2012-09-06/un-chemicals-health/57634948/1
"UNITED NATIONS – The potential cost of pesticide-related illnesses in sub-Saharan African between 2005 and 2020 could reach $90 billion, according to a U.N. report released Wednesday highlighting the growing health and environmental hazards from chemicals."
http://www.usatoday.com/news/health/story/2012-09-06/un-chemicals-health/57634948/1
"UNITED NATIONS – The potential cost of pesticide-related illnesses in sub-Saharan African between 2005 and 2020 could reach $90 billion, according to a U.N. report released Wednesday highlighting the growing health and environmental hazards from chemicals."
Toxic GMOs and Preserving Organic Standards
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What happens when rats are fed a lifetime diet of Monsanto's GMO corn, or exposed to Monsanto's top-selling weedkiller, Roundup? It's not pretty. Tumors. Kidney damage. Liver damage. 
Oxidized lignite from coal, fertilizer additives that cause acid rain, the pesticide PGML that harms beneficial soil organisms, synthetic nutrients to keep chickens alive under factory farm conditions, synthetic ingredients in infant formula.
Consumers beware! Products bearing the NPA Natural Seal are not as natural as you think. The Natural Products Association (NPA) has certified more than 800 personal care products with its NPA Natural Seal – and many of those products contain genetically modified ingredients.
In less than 3 weeks, California voters will begin casting their ballots – yes or no – on Prop 37, the California Right to Know Genetically Engineered Food Act. By November 6, the most critical – and winnable – battle to label GMOs will be decided.
Global Citizens Alliance for Seed Freedom is a global campaign to alert citizens and governments around the world on how precarious our seed supply has become – and as a consequence how precarious our food security has become. From October 2nd (Gandhi's Birth Anniversary), to October 16th (World Food Day) Global Alliance for Seed Freedom is planning a Global Seed Freedom Fortnight of Action.
On September 12 activists calling themselves the Genetic Crimes Unit shut down shipping and receiving access points at Monsanto's Oxnard seed distribution facility. By peacefully blocking the exit and access points the group effectively shut down the distribution of genetically engineered seeds for a day.
Essential Reading for the Week
Is your scent making you ill? Today's obsession with perfuming everything from candles to bin liners could be to blame
Is your scent making you ill? Today's obsession with perfuming everything from candles to bin liners could be to blame
http://www.dailymail.co.uk/health/article-2204745/Is-scent-making-ill-Todays-obsession-perfuming-candles-bin-liners-blame.html
"The smell of fresh air is becoming something of a distant memory, thanks to our increasing use of fragrance. From air fresheners to scented candles, perfumed loo roll and bin liners, in-car scents and even scented socks, we live in a miasma of scent. Share a lift or train carriage and the aroma of spray deodorant and perfume can be overwhelming. Recent figures show seven in ten use air fresheners or scented candles to keep our homes smelling sweet. Yet recent reports suggest that perfumed products could affect our health, causing problems including allergies, asthma and migraine, and even interfere with sexual desire."
http://www.dailymail.co.uk/health/article-2204745/Is-scent-making-ill-Todays-obsession-perfuming-candles-bin-liners-blame.html
"The smell of fresh air is becoming something of a distant memory, thanks to our increasing use of fragrance. From air fresheners to scented candles, perfumed loo roll and bin liners, in-car scents and even scented socks, we live in a miasma of scent. Share a lift or train carriage and the aroma of spray deodorant and perfume can be overwhelming. Recent figures show seven in ten use air fresheners or scented candles to keep our homes smelling sweet. Yet recent reports suggest that perfumed products could affect our health, causing problems including allergies, asthma and migraine, and even interfere with sexual desire."
Pesticide and Insect Repellent Mixture (Permethrin and DEET) Induces Epigenetic Transgenerational Inheritance of Disease and Sperm Epimutations
Pesticide and Insect Repellent Mixture (Permethrin and DEET) Induces Epigenetic Transgenerational Inheritance of Disease and Sperm Epimutations
http://www.sciencedirect.com/science/article/pii/S0890623812002948
Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, Michael K. Skinner, Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236
http://dx.doi.org/10.1016/j.reprotox.2012.08.010, How to Cite or Link Using DOI
http://www.sciencedirect.com/science/article/pii/S0890623812002948
Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, Michael K. Skinner, Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236
http://dx.doi.org/10.1016/j.reprotox.2012.08.010, How to Cite or Link Using DOI
Abstract
Environmental compounds are known to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a "pesticide mixture" (pesticide permethrin and insect repellent N,N-Diethyl-meta-toluamide, DEET) promotes epigenetic transgenerational inheritance of disease and associated DNA methylation epimutations in sperm. Gestating F0 generation female rats were exposed during fetal gonadal sex determination and the incidence of disease evaluated in F1 and F3 generations. There were significant increases in the incidence of total diseases in animals from pesticide lineage F1 and F3 generation animals. Pubertal abnormalities, testis disease, and ovarian disease (primordial follicle loss and polycystic ovarian disease) were increased in F3 generation animals. Analysis of the pesticide lineage F3 generation sperm epigenome identified 363 differential DNA methylation regions (DMR) termed epimutations. Observations demonstrate that a pesticide mixture (permethrin and DEET) can promote epigenetic transgenerational inheritance of adult onset disease and potential sperm epigenetic biomarkers for ancestral environmental exposures.
Environmental compounds are known to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a "pesticide mixture" (pesticide permethrin and insect repellent N,N-Diethyl-meta-toluamide, DEET) promotes epigenetic transgenerational inheritance of disease and associated DNA methylation epimutations in sperm. Gestating F0 generation female rats were exposed during fetal gonadal sex determination and the incidence of disease evaluated in F1 and F3 generations. There were significant increases in the incidence of total diseases in animals from pesticide lineage F1 and F3 generation animals. Pubertal abnormalities, testis disease, and ovarian disease (primordial follicle loss and polycystic ovarian disease) were increased in F3 generation animals. Analysis of the pesticide lineage F3 generation sperm epigenome identified 363 differential DNA methylation regions (DMR) termed epimutations. Observations demonstrate that a pesticide mixture (permethrin and DEET) can promote epigenetic transgenerational inheritance of adult onset disease and potential sperm epigenetic biomarkers for ancestral environmental exposures.
Centennial man with "popcorn lung" disease gets $7.3 million award
Centennial man with "popcorn lung" disease gets $7.3 million award
http://www.denverpost.com/business/ci_21586951/centennial-man-popcorn-lung-disease-gets-7-3
"A federal jury in Denver on Wednesday awarded $7.3 million in damages to a Centennial man diagnosed with "popcorn lung" — the scarring of airways caused by chemical fumes from artificial flavorings."
http://www.denverpost.com/business/ci_21586951/centennial-man-popcorn-lung-disease-gets-7-3
"A federal jury in Denver on Wednesday awarded $7.3 million in damages to a Centennial man diagnosed with "popcorn lung" — the scarring of airways caused by chemical fumes from artificial flavorings."
UPDATE 2-U.S. needs arsenic limits in rice - Consumer Reports
UPDATE 2-U.S. needs arsenic limits in rice - Consumer Reports
http://www.reuters.com/article/2012/09/19/usa-rice-arsenic-idUSL1E8KJ79J20120919?type=marketsNews
* Group tests more than 60 popular rice products
* Nearly all contained some level of inorganic arsenic
* Recommends consumers limit weekly intake
* Food industry opposes singling out one source of arsenic
http://www.reuters.com/article/2012/09/19/usa-rice-arsenic-idUSL1E8KJ79J20120919?type=marketsNews
* Group tests more than 60 popular rice products
* Nearly all contained some level of inorganic arsenic
* Recommends consumers limit weekly intake
* Food industry opposes singling out one source of arsenic
Scientists: overuse of antibiotics in animal agriculture endangers humans (UK)
Scientists: overuse of antibiotics in animal agriculture endangers humans (UK)
http://www.guardian.co.uk/science/2012/sep/19/scientists-antibiotics-animal-agriculture
"The overuse of antibiotics in animal agriculture and medicine is putting human lives at unnecessary risk and driving up medical costs, according to a group of group of 150 scientists that includes a former head of the Food and Drug Administration (FDA). Along with 50 US farmers and ranchers who have opted out of using non-therapeutic antibiotics in their animal feed, the scientists are calling on the FDA and Congress to work together to regulate unnecessary use of antibiotics in animal agriculture. In twin statements released on Wednesday, the scientists and farmers said that a growing body of research supported the conclusion that overuse of antibiotics in animal agriculture is fueling a health crisis. One statement cited a study which estimated that antibiotic-resistant infections cost $20bn annually to hospitals alone."
http://www.guardian.co.uk/science/2012/sep/19/scientists-antibiotics-animal-agriculture
"The overuse of antibiotics in animal agriculture and medicine is putting human lives at unnecessary risk and driving up medical costs, according to a group of group of 150 scientists that includes a former head of the Food and Drug Administration (FDA). Along with 50 US farmers and ranchers who have opted out of using non-therapeutic antibiotics in their animal feed, the scientists are calling on the FDA and Congress to work together to regulate unnecessary use of antibiotics in animal agriculture. In twin statements released on Wednesday, the scientists and farmers said that a growing body of research supported the conclusion that overuse of antibiotics in animal agriculture is fueling a health crisis. One statement cited a study which estimated that antibiotic-resistant infections cost $20bn annually to hospitals alone."
Agent Orange chemical in GM war on resistant weeds
Agent Orange chemical in GM war on resistant weeds
http://www.bbc.co.uk/news/science-environment-19585341
"A US pharmaceutical company is set to introduce a controversial new genetically modified corn to help farmers fight resistant weeds. Dow Agrosciences says its new GM product will use a chemical that was once a component of the Vietnam war defoliant, Agent Orange. It is needed they say because so called "superweeds" are now affecting up to 15 million acres of American crops. Dow argues the new approach is safe and sustainable." ?????
http://www.bbc.co.uk/news/science-environment-19585341
"A US pharmaceutical company is set to introduce a controversial new genetically modified corn to help farmers fight resistant weeds. Dow Agrosciences says its new GM product will use a chemical that was once a component of the Vietnam war defoliant, Agent Orange. It is needed they say because so called "superweeds" are now affecting up to 15 million acres of American crops. Dow argues the new approach is safe and sustainable." ?????
Foes of Modified Corn Find Support in a Study
Foes of Modified Corn Find Support in a Study
http://www.nytimes.com/2012/09/20/business/energy-environment/disputed-study-links-modified-corn-to-greater-health-risks.html
"Rats fed either genetically engineered corn or the herbicide Roundup had an increased risk of developing tumors, suffering organ damage and dying prematurely, according to a new study that was immediately swept up into the furor surrounding crop biotechnology when it was released Wednesday.
The study, conducted by a prominent opponent of genetically engineered crops, was immediately criticized by some other scientists, who said the methods were flawed and that other research had not found similar problems.
But in California, proponents of a ballot measure that would require genetically modified foods to be labeled immediately seized on the study as support for their cause. The French government ordered a review of the findings, saying they could possibly result in the suspension of European imports of that type of corn."
http://www.nytimes.com/2012/09/20/business/energy-environment/disputed-study-links-modified-corn-to-greater-health-risks.html
"Rats fed either genetically engineered corn or the herbicide Roundup had an increased risk of developing tumors, suffering organ damage and dying prematurely, according to a new study that was immediately swept up into the furor surrounding crop biotechnology when it was released Wednesday.
The study, conducted by a prominent opponent of genetically engineered crops, was immediately criticized by some other scientists, who said the methods were flawed and that other research had not found similar problems.
But in California, proponents of a ballot measure that would require genetically modified foods to be labeled immediately seized on the study as support for their cause. The French government ordered a review of the findings, saying they could possibly result in the suspension of European imports of that type of corn."
Wednesday, September 19, 2012
Pesticide and Insect Repellent Mixture (Permethrin and DEET) Induces Epigenetic Transgenerational Inheritance of Disease and Sperm Epimutations
Pesticide and Insect Repellent Mixture (Permethrin and DEET) Induces Epigenetic Transgenerational Inheritance of Disease and Sperm Epimutations
http://www.sciencedirect.com/science/article/pii/S0890623812002948
Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, Michael K. Skinner,
http://www.sciencedirect.com/science/article/pii/S0890623812002948
Mohan Manikkam, Rebecca Tracey, Carlos Guerrero-Bosagna, Michael K. Skinner,
Center for Reproductive Biology, School of Biological Sciences, Washington State University, Pullman, WA 99164-4236
Abstract
Environmental compounds are known to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a "pesticide mixture" (pesticide permethrin and insect repellent N,N-Diethyl-meta-toluamide, DEET) promotes epigenetic transgenerational inheritance of disease and associated DNA methylation epimutations in sperm. Gestating F0 generation female rats were exposed during fetal gonadal sex determination and the incidence of disease evaluated in F1 and F3 generations. There were significant increases in the incidence of total diseases in animals from pesticide lineage F1 and F3 generation animals. Pubertal abnormalities, testis disease, and ovarian disease (primordial follicle loss and polycystic ovarian disease) were increased in F3 generation animals. Analysis of the pesticide lineage F3 generation sperm epigenome identified 363 differential DNA methylation regions (DMR) termed epimutations. Observations demonstrate that a pesticide mixture (permethrin and DEET) can promote epigenetic transgenerational inheritance of adult onset disease and potential sperm epigenetic biomarkers for ancestral environmental exposures.
Environmental compounds are known to promote epigenetic transgenerational inheritance of disease. The current study was designed to determine if a "pesticide mixture" (pesticide permethrin and insect repellent N,N-Diethyl-meta-toluamide, DEET) promotes epigenetic transgenerational inheritance of disease and associated DNA methylation epimutations in sperm. Gestating F0 generation female rats were exposed during fetal gonadal sex determination and the incidence of disease evaluated in F1 and F3 generations. There were significant increases in the incidence of total diseases in animals from pesticide lineage F1 and F3 generation animals. Pubertal abnormalities, testis disease, and ovarian disease (primordial follicle loss and polycystic ovarian disease) were increased in F3 generation animals. Analysis of the pesticide lineage F3 generation sperm epigenome identified 363 differential DNA methylation regions (DMR) termed epimutations. Observations demonstrate that a pesticide mixture (permethrin and DEET) can promote epigenetic transgenerational inheritance of adult onset disease and potential sperm epigenetic biomarkers for ancestral environmental exposures.
Eight skin-whitening products found to exceed mercury toxicity limits
Eight skin-whitening products found to exceed mercury toxicity limits
http://newsinfo.inquirer.net/272106/eight-skin-whitening-products-found-to-exceed-mercury-toxicity-limits
http://newsinfo.inquirer.net/272106/eight-skin-whitening-products-found-to-exceed-mercury-toxicity-limits
"Eight whitening products being sold in Cebu City's stores were found to contain high concentrations of toxic mercury, according to results of test-buys by a Cebu-based ecology group.
The Philippine Earth Justice Center (PEJC) said test buys done on Sept. 13 and 14 in four beauty shops showed that the creams exceeded the allowable mercury limit of one part per million (ppm)."
2 of 3 Americans Are Concerned With Toxins Found in Common Household Products, Study Shows
2 of 3 Americans Are Concerned With Toxins Found in Common Household Products, Study Shows
http://www.rdmag.com/News/FeedsAP/2012/09/environment-2-of-3-americans-are-concerned-with-toxins-found-i/
"Nearly two-thirds of all Americans (64%) say they are "concerned" or "very concerned" about potentially harmful chemicals and petroleum-based ingredients found in everyday personal care, household cleaning, laundry and baby care products, according to a study released today. Top concerns of petroleum-based products are "long term health effects" (75%) and "absorption through the skin" (71%). Concerns were similar across age, gender and other demographic categories."
http://www.rdmag.com/News/FeedsAP/2012/09/environment-2-of-3-americans-are-concerned-with-toxins-found-i/
"Nearly two-thirds of all Americans (64%) say they are "concerned" or "very concerned" about potentially harmful chemicals and petroleum-based ingredients found in everyday personal care, household cleaning, laundry and baby care products, according to a study released today. Top concerns of petroleum-based products are "long term health effects" (75%) and "absorption through the skin" (71%). Concerns were similar across age, gender and other demographic categories."
Rising levels of ARSENIC in rice 'could be toxic and pose cancer risk' - and there are NO federal standards over how much is allowed in food (UK)
Rising levels of ARSENIC in rice 'could be toxic and pose cancer risk' - and there are NO federal standards over how much is allowed in food (UK)
Is your workplace harming your health?
Is your workplace harming your health?
http://www.dominicantoday.com/dr/opinion/2012/9/19/45153/Is-your-workplace-harming-your-health
'Toxicity and its damaging effects are virtually unknown to the majority of people. It is now estimated that 80 percent of jobs are sedentary and the workplace to be one of the most toxic environments. Constant exposure to common workplace and household toxins has been found to cause an assortment of severe health conditions."
http://www.dominicantoday.com/dr/opinion/2012/9/19/45153/Is-your-workplace-harming-your-health
'Toxicity and its damaging effects are virtually unknown to the majority of people. It is now estimated that 80 percent of jobs are sedentary and the workplace to be one of the most toxic environments. Constant exposure to common workplace and household toxins has been found to cause an assortment of severe health conditions."
BPA in Food Packaging Tied to Child Obesity: Study
BPA in Food Packaging Tied to Child Obesity: Study
http://www.nlm.nih.gov/medlineplus/news/fullstory_129374.html
"The common chemical bisphenol A (BPA), found in the lining of many aluminum cans and a variety of food packaging, may be adding to the obesity epidemic among children and teens, according to a new study."
http://www.nlm.nih.gov/medlineplus/news/fullstory_129374.html
"The common chemical bisphenol A (BPA), found in the lining of many aluminum cans and a variety of food packaging, may be adding to the obesity epidemic among children and teens, according to a new study."
Friday, September 14, 2012
Indoor air pollutants in office environments: Assessment of comfort, health, and performance.
Indoor air pollutants in office environments: Assessment of comfort, health, and performance.
http://www.ncbi.nlm.nih.gov/pubmed/22954455
http://www.ncbi.nlm.nih.gov/pubmed/22954455
Wolkoff P. Int J Hyg Environ Health. 2012 Sep 3. [Epub ahead of print]
Source
National Research Centre for the Working Environment, Copenhagen, Denmark.
Abstract
Concentrations of volatile organic compounds (VOCs) in office environments are generally too low to cause sensory irritation in the eyes and airways on the basis of estimated thresholds for sensory irritation. Furthermore, effects in the lungs, e.g. inflammatory effects, have not been substantiated at indoor relevant concentrations. Some VOCs, including formaldehyde, in combination may under certain environmental and occupational conditions result in reported sensory irritation. The odour thresholds of several VOCs are low enough to influence the perceived air quality that result in a number of acute effects from reported sensory irritation in eyes and airways and deterioration of performance. The odour perception (air quality) depends on a number of factors that may influence the odour impact. There is neither clear indication that office dust particles may cause sensory effects, even not particles spiked with glucans, aldehydes or phthalates, nor lung effects; some inflammatory effects may be observed among asthmatics. Ozone-initiated terpene reaction products may be of concern in ozone-enriched environments (≥0.1mg/m(3)) and elevated limonene concentrations, partly due to the production of formaldehyde. Ambient particles may cause cardio-pulmonary effects, especially in susceptible people (e.g. elderly and sick people); even, short-term effects, e.g. from traffic emission and candle smoke may possibly have modulating and delayed effects on the heart, but otherwise adverse effects in the airways and lung functions have not been observed. Secondary organic aerosols generated in indoor ozone-initiated terpene reactions appear not to cause adverse effects in the airways; rather the gaseous products are relevant. Combined exposure to particles and ozone may evoke effects in subgroups of asthmatics. Based on an analysis of thresholds for odour and sensory irritation selected compounds are recommended for measurements to assess the indoor air quality and to minimize reports of irritation symptoms, deteriorated performance, and cardiovascular and pulmonary effects.
PMID: 22954455 [PubMed - as supplied by publisher]
National Research Centre for the Working Environment, Copenhagen, Denmark.
Abstract
Concentrations of volatile organic compounds (VOCs) in office environments are generally too low to cause sensory irritation in the eyes and airways on the basis of estimated thresholds for sensory irritation. Furthermore, effects in the lungs, e.g. inflammatory effects, have not been substantiated at indoor relevant concentrations. Some VOCs, including formaldehyde, in combination may under certain environmental and occupational conditions result in reported sensory irritation. The odour thresholds of several VOCs are low enough to influence the perceived air quality that result in a number of acute effects from reported sensory irritation in eyes and airways and deterioration of performance. The odour perception (air quality) depends on a number of factors that may influence the odour impact. There is neither clear indication that office dust particles may cause sensory effects, even not particles spiked with glucans, aldehydes or phthalates, nor lung effects; some inflammatory effects may be observed among asthmatics. Ozone-initiated terpene reaction products may be of concern in ozone-enriched environments (≥0.1mg/m(3)) and elevated limonene concentrations, partly due to the production of formaldehyde. Ambient particles may cause cardio-pulmonary effects, especially in susceptible people (e.g. elderly and sick people); even, short-term effects, e.g. from traffic emission and candle smoke may possibly have modulating and delayed effects on the heart, but otherwise adverse effects in the airways and lung functions have not been observed. Secondary organic aerosols generated in indoor ozone-initiated terpene reactions appear not to cause adverse effects in the airways; rather the gaseous products are relevant. Combined exposure to particles and ozone may evoke effects in subgroups of asthmatics. Based on an analysis of thresholds for odour and sensory irritation selected compounds are recommended for measurements to assess the indoor air quality and to minimize reports of irritation symptoms, deteriorated performance, and cardiovascular and pulmonary effects.
PMID: 22954455 [PubMed - as supplied by publisher]
School environment as predictor of teacher sick leave: data-linked prospective cohort study.
School environment as predictor of teacher sick leave: data-linked prospective cohort study.
http://www.ncbi.nlm.nih.gov/pubmed/22966903
http://www.ncbi.nlm.nih.gov/pubmed/22966903
Ervasti J, Kivimäki M, Kawachi I, Subramanian S, Pentti J, Oksanen T, Puusniekka R, Pohjonen T, Vahtera J, Virtanen M. BMC Public Health. 2012 Sep 11;12(1):770. [Epub ahead of print]
Abstract
Abstract
ABSTRACT:
BACKGROUND:
Poor indoor air quality (IAQ) and psychosocial problems are common in schools worldwide, yet longitudinal research on the issue is scarce. We examined whether the level of or a change in pupil-reported school environment (IAQ, school satisfaction, and bullying) predicts recorded sick leaves among teachers.
METHODS:
Changes in the school environment were assessed using pupil surveys at two time points (2001/02 and 2004/05) in 92 secondary schools in Finland. Variables indicating change were based on median values at baseline. We linked these data to individual-level records of teachers' (n = 1678) sick leaves in 2001--02 and in 2004--05.
Changes in the school environment were assessed using pupil surveys at two time points (2001/02 and 2004/05) in 92 secondary schools in Finland. Variables indicating change were based on median values at baseline. We linked these data to individual-level records of teachers' (n = 1678) sick leaves in 2001--02 and in 2004--05.
RESULTS:
Multilevel multinomial logistic regression models adjusted for baseline sick leave and covariates showed a decreased risk for short-term (one to three days) sick leaves among teachers working in schools with good perceived IAQ at both times (OR = 0.6, 95% CI: 0.5-0.9), and for those with a positive change in IAQ (OR = 0.6, 95% CI: 0.4-0.9), compared to teachers in schools where IAQ was constantly poor. Negative changes in pupil school satisfaction (OR = 1.8, 95% CI: 1.1-2.8) and bullying (OR = 1.5, 95% CI: 1.0-2.3) increased the risk for short-term leaves among teachers when compared to teachers in schools where the level of satisfaction and bullying had remained stable. School environment factors were not associated with long-term sick leaves.
Multilevel multinomial logistic regression models adjusted for baseline sick leave and covariates showed a decreased risk for short-term (one to three days) sick leaves among teachers working in schools with good perceived IAQ at both times (OR = 0.6, 95% CI: 0.5-0.9), and for those with a positive change in IAQ (OR = 0.6, 95% CI: 0.4-0.9), compared to teachers in schools where IAQ was constantly poor. Negative changes in pupil school satisfaction (OR = 1.8, 95% CI: 1.1-2.8) and bullying (OR = 1.5, 95% CI: 1.0-2.3) increased the risk for short-term leaves among teachers when compared to teachers in schools where the level of satisfaction and bullying had remained stable. School environment factors were not associated with long-term sick leaves.
CONCLUSIONS:
Good and improved IAQ are associated with decreased teacher absenteeism. While pupil-related psychosocial factors also contribute to sick leaves, no effect modification or mediation of psychosocial factors on the association between IAQ and sick leave was observed.
Good and improved IAQ are associated with decreased teacher absenteeism. While pupil-related psychosocial factors also contribute to sick leaves, no effect modification or mediation of psychosocial factors on the association between IAQ and sick leave was observed.
PMID: 22966903 [PubMed - as supplied by publisher]
Thursday, September 13, 2012
Polluting The Water With Toothpaste, Shampoo, And Drugs
Polluting The Water With Toothpaste, Shampoo, And Drugs
"OREGON CITY, Ore. — Dave Sohm's house is immaculate. Every tool in the garage has its own hook. The kitchen countertops gleam. But in his house –- as with most houses –- toxic chemicals are hiding in plain sight. Sohm wants to know where. "I'm curious about what things there are," he says. "I don't know what impacts I may be having that I'm not even aware of." Jen Coleman, an outreach director for the Oregon Environmental Council is at Sohm's house to help. Armed with a list of chemicals that have toxic effects on people and the environment, Coleman digs through cabinets, checks ingredient lists and compares them with contaminants that have been found in local waterways."
Fast Facts: What You Should Know about Multiple Chemical Sensitivity (Oregon Public Health Division, Office of Environmental Public Health)
Fast Facts: What You Should Know about Multiple Chemical Sensitivity
(Oregon Public Health Division, Office of Environmental Public Health)
http://public.health.oregon.gov/HealthyEnvironments/TrackingAssessment/EnvironmentalHealthAssessment/Documents/MCS%20fact%20sheet.pdf
(Oregon Public Health Division, Office of Environmental Public Health)
http://public.health.oregon.gov/HealthyEnvironments/TrackingAssessment/EnvironmentalHealthAssessment/Documents/MCS%20fact%20sheet.pdf
EWG's Cleaning Product Lookup
EWG's Cleaning Product Lookup
[COMMENT: This is where you can check the ratings of individual products in terms of health and enviornmental effects. It's quite good!]
Retract the Flawed 'Organic Study' Linked to Big Tobacco and Pro-GMO Corps
[COMMENT: Very biased viewpoint on this study and article below trying to downplay the truth of the flawed study. Over and over again, these industry funded organic vs. conventional studies look only at nutritional content. Who eats organic because they think it has more nutrients? No one. People eat organic to avoid toxic pesticides and because they support a farming method that is more environmentally friendly and kind to the soil. Irregardless of the researchers opinion, it is significant to find less pesticides in the body / urine of people eating organic. Claiming "we don't know" whether that has any health significance is just plain ignorance and amounts to putting ones head in the sand. Likewise, conventional products have been shown to contain more antibiotic resistant bacteria. Please sign petition to retract the study below.]
Lots of chatter, anger over Stanford organic food study
http://www.latimes.com/health/boostershots/la-heb-stanford-organic-food-study-controversy-20120911,0,173210.story
PETITION
Retract the Flawed 'Organic Study' Linked to Big Tobacco and Pro-GMO Corps
http://www.change.org/petitions/retract-the-flawed-organic-study-linked-to-big-tobacco-and-pro-gmo-corps
http://www.latimes.com/health/boostershots/la-heb-stanford-organic-food-study-controversy-20120911,0,173210.story
PETITION
Retract the Flawed 'Organic Study' Linked to Big Tobacco and Pro-GMO Corps
http://www.change.org/petitions/retract-the-flawed-organic-study-linked-to-big-tobacco-and-pro-gmo-corps
Wednesday, September 12, 2012
Traffic May Keep City Dwellers Awake, Harming Health
Traffic May Keep City Dwellers Awake, Harming Health
http://www.nlm.nih.gov/medlineplus/news/fullstory_129135.html
"Nighttime noise pollution -- in particular the din of traffic -- in urban areas puts city residents at risk for disrupted sleep and annoyance, researchers report.
http://www.nlm.nih.gov/medlineplus/news/fullstory_129135.html
"Nighttime noise pollution -- in particular the din of traffic -- in urban areas puts city residents at risk for disrupted sleep and annoyance, researchers report.
Such chronic sleep disturbance could lead to serious health consequences, including increased risk for heart attack and high blood pressure, according to the new study. In addition, nighttime noise can also lead to poor sleep quality, which can cause morning tiredness and insomnia."
Laundry Detergent Packs Pose Poisoning Threat to Toddlers
Laundry Detergent Packs Pose Poisoning Threat to Toddlers
http://www.nlm.nih.gov/medlineplus/news/fullstory_128962.html
"Doctors at a children's hospital in Great Britain reported seeing five such cases of detergent poisoning among children under age 2 over the past 18 months. Each of the children suffered serious chemical burns to the esophagus."
http://www.nlm.nih.gov/medlineplus/news/fullstory_128962.html
"Doctors at a children's hospital in Great Britain reported seeing five such cases of detergent poisoning among children under age 2 over the past 18 months. Each of the children suffered serious chemical burns to the esophagus."
Tuesday, September 11, 2012
Is inflammation a mitochondrial dysfunction-dependent event in Fibromyalgia?
Is inflammation a mitochondrial dysfunction-dependent event in Fibromyalgia?
http://www.ncbi.nlm.nih.gov/pubmed?term=Is%20inflammation%20a%20mitochondrial%20dysfunction-dependent%20event%20in%20Fibromyalgia%3F
Cordero MD, Díaz-Parrado E, Carrión AM, Alfonsi S, Sánchez-Alcázar JA, Bullon P, Battino M, de Miguel M.
Antioxid Redox Signal. 2012 Sep 3. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed?term=Is%20inflammation%20a%20mitochondrial%20dysfunction-dependent%20event%20in%20Fibromyalgia%3F
Cordero MD, Díaz-Parrado E, Carrión AM, Alfonsi S, Sánchez-Alcázar JA, Bullon P, Battino M, de Miguel M.
Antioxid Redox Signal. 2012 Sep 3. [Epub ahead of print]
Source
Dpto. Citología e Histología Normal y Patológica, Facultad de Medicina. Universidad de Sevilla, 41009 Sevilla-Spain, Avda. Sánchez-Pizjuán s/n , Sevilla, Spain, 41009, +34 95 4551797 , +34 95 4551799; mdcormor@us.es.
Abstract
Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress and inflammation in FM. We studied thirty women diagnosed with FM and twenty healthy women. Blood mononuclear cells (BMCs) from FM patients showed reduced level of CoQ10, mtDNA contents, and high level of mitochondrial ROS, serum TNF-alpha and transcript levels. A significant negative correlation between CoQ10 and TNF-alpha levels (r = -0.588; P<0.01), and a positive correlation between ROS and TNF-alpha levels (r = 0.791; P<0.001) were observed accompanied by a significant correlation of VAS with serum TNF-alpha and transcript levels (r = 0.4507; P<0.05 and r = 0.7089; P<0.001, respectively). TNF-alpha release was observed in an in vitro (BMCs) and in vivo (mice) CoQ10 deficiency model. Oral CoQ10 supplementation restored biochemical parameters and induced a significant improvement in clinical symptoms (P0.001). These results lead to the hypothesis that inflammation could be a mitochondrial dysfunction-dependent event implicated in the pathophysiology of FM in several patients indicating at mitochondria as a possible new therapeutic target.
Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress and inflammation in FM. We studied thirty women diagnosed with FM and twenty healthy women. Blood mononuclear cells (BMCs) from FM patients showed reduced level of CoQ10, mtDNA contents, and high level of mitochondrial ROS, serum TNF-alpha and transcript levels. A significant negative correlation between CoQ10 and TNF-alpha levels (r = -0.588; P<0.01), and a positive correlation between ROS and TNF-alpha levels (r = 0.791; P<0.001) were observed accompanied by a significant correlation of VAS with serum TNF-alpha and transcript levels (r = 0.4507; P<0.05 and r = 0.7089; P<0.001, respectively). TNF-alpha release was observed in an in vitro (BMCs) and in vivo (mice) CoQ10 deficiency model. Oral CoQ10 supplementation restored biochemical parameters and induced a significant improvement in clinical symptoms (P0.001). These results lead to the hypothesis that inflammation could be a mitochondrial dysfunction-dependent event implicated in the pathophysiology of FM in several patients indicating at mitochondria as a possible new therapeutic target.
PMID: 22938055 [PubMed - as supplied by publisher]
Many Cleaning Products Said to Contain Toxins
Many Cleaning Products Said to Contain Toxins
http://www.webmd.com/news/20120910/many-cleaning-products-said-to-contain-toxins
"Household cleaning products may contain toxic substances linked to health problems such as asthma, allergic reactions, and cancer, according to a new report by the Environmental Working Group. The environmental group rated more than 2,000 household cleaners -- from laundry soaps and stain removers to bathroom cleaners and floor care products. Products are graded A to F based on the safety of the ingredients and how well the maker discloses those ingredients."
http://www.webmd.com/news/20120910/many-cleaning-products-said-to-contain-toxins
"Household cleaning products may contain toxic substances linked to health problems such as asthma, allergic reactions, and cancer, according to a new report by the Environmental Working Group. The environmental group rated more than 2,000 household cleaners -- from laundry soaps and stain removers to bathroom cleaners and floor care products. Products are graded A to F based on the safety of the ingredients and how well the maker discloses those ingredients."
Taking action on developmental toxicity: Scientists' duties to protect children
Taking action on developmental toxicity: Scientists' duties to protect children
http://www.ehjournal.net/content/pdf/1476-069X-11-61.pdf
Kristin Shrader-Frechette. Environmental Health 2012, 11:61 doi:10.1186/1476-069X-11-61
Published: 10 September 2012
Abstract (provisional)
Background
Although adaptation and proper biological functioning require developmental programming, pollutant interference can cause developmental toxicity or DT.
Objectives
This commentary assesses whether it is ethical for citizens/physicians/scientists to allow avoidable DT.
Methods
Using conceptual, economic, ethical, and logical analysis, the commentary assesses what major ethical theories and objectors would say regarding the defensibility of allowing avoidable DT.
Results
The commentary argues that (1) none of the four major ethical theories (based, respectively, on virtue, natural law, utility, or equity) can consistently defend avoidable DT because it unjustifiably harms, respectively, individual human flourishing, human life, the greatest good, and equality. (2) Justice also requires leaving "as much and as good" biological resources for all, including future generations possibly harmed if epigenetic change is heritable. (3) Scientists/physicians have greater justice-based duties, than ordinary/average citizens, to help stop DT because they help cause it and have greater professional abilities/opportunities to help stop it. (4) Scientists/physicians likewise have greater justice-based duties, than ordinary/average citizens, to help stop DT because they benefit more from it, given their relatively greater education/consumption/income. The paper shows that major objections to (3)-(4) fail on logical, ethical, or scientific grounds, then closes with practical suggestions for implementing its proposals.
Conclusions
Because allowing avoidable DT is ethically indefensible, citizens---and especially physicians/scientists---have justice-based duties to help stop DT.
http://www.ehjournal.net/content/pdf/1476-069X-11-61.pdf
Kristin Shrader-Frechette. Environmental Health 2012, 11:61 doi:10.1186/1476-069X-11-61
Published: 10 September 2012
Abstract (provisional)
Background
Although adaptation and proper biological functioning require developmental programming, pollutant interference can cause developmental toxicity or DT.
Objectives
This commentary assesses whether it is ethical for citizens/physicians/scientists to allow avoidable DT.
Methods
Using conceptual, economic, ethical, and logical analysis, the commentary assesses what major ethical theories and objectors would say regarding the defensibility of allowing avoidable DT.
Results
The commentary argues that (1) none of the four major ethical theories (based, respectively, on virtue, natural law, utility, or equity) can consistently defend avoidable DT because it unjustifiably harms, respectively, individual human flourishing, human life, the greatest good, and equality. (2) Justice also requires leaving "as much and as good" biological resources for all, including future generations possibly harmed if epigenetic change is heritable. (3) Scientists/physicians have greater justice-based duties, than ordinary/average citizens, to help stop DT because they help cause it and have greater professional abilities/opportunities to help stop it. (4) Scientists/physicians likewise have greater justice-based duties, than ordinary/average citizens, to help stop DT because they benefit more from it, given their relatively greater education/consumption/income. The paper shows that major objections to (3)-(4) fail on logical, ethical, or scientific grounds, then closes with practical suggestions for implementing its proposals.
Conclusions
Because allowing avoidable DT is ethically indefensible, citizens---and especially physicians/scientists---have justice-based duties to help stop DT.
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