"When you choose to use fragrances, chemicals, or pesticides,
You are not simply making a choice for yourself,
You are making a choice for everyone around you."
© MCS America


Saturday, May 30, 2009

NEWSLETTER: MCS America News - June 2009

MCSA NEWS
June 2009, Volume 4, Issue 6

 

Entire PDF Edition: http://mcs-america.org/june2009.pdf  (View, Download, and Print)
NEW!  Entire Online Edition: http://mcs-america.org/mcsanewsjune2009.htm   (View as a Webpage)

 

 

Direct Links to Articles Inside This Issue:

 

Governors and Mayors Warn of the Toxic Effects of Chemicals

PDF Version:      http://mcs-america.org/June2009pg12345.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Governors_and_Mayors

 

Social Security Disability   A Chink in the Armor

PDF Version:      http://mcs-america.org/June2009pg67.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Social_Security_

 

SAMe   Wonder Nutrient

PDF Version:      http://mcs-america.org/June2009pg89101112.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_SAMe__

 

The Prevalence of Fragrance Sensitivity

PDF Version:      http://mcs-america.org/June2009pg13.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_The_Prevalence_of

 

Welcome to MCS   Time to Look at Your Kitchen in a Different Light

PDF Version:      http://mcs-america.org/June2009pg141516.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Welcome_to_MCS

 

Bird, Bees, and Electromagnetic Pollution

PDF Version:      http://mcs-america.org/June2009pg171819.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Birds,_Bees,_and

 

The Impact of a Sweet Fragrance

PDF Version:      http://mcs-america.org/June2009pg20.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_The_Impact_of

 

Q&A   Public HVAC Scent Diffusers

PDF Version:      http://mcs-america.org/June2009pg21.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Proposed_Treatment_of

 

Q&A   Low Dose Antigens

PDF Version:      http://mcs-america.org/June2009pg22.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Fast_Metabolism_Linked

 

$3.3 Million Awarded in Mold Suit

PDF Version:      http://mcs-america.org/June2009pg23.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_$3.3_Million_Awarded

 

Vaccinated Children Three Times More Likely To Be Hospitalized

PDF Version:      http://mcs-america.org/June2009pg24.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Vaccinated_Children_Three

 

Irradiated Foods May Cause Serious Brain Damage

PDF Version:      http://mcs-america.org/June2009pg25.pdf 

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Irradiated_Foods_May

 

Patient Support and Resources

PDF Version:      http://mcs-america.org/June2009pg2627282930313233.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Resources_and_Support

 

Community News

PDF Version:      http://mcs-america.org/June2009pg34.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Community_News_4

 

Featured Research

PDF Version:      http://mcs-america.org/June2009pg353637.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Featured_Research_Studies_4

 

Multiple Chemical Sensitivities America
http://www.mcs-america.org admin@mcs-america.org

 

 

Copyrighted © 2008  MCS America

 

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NEWSLETTER: MCS America News - June 2009

MCSA NEWS
June 2009, Volume 4, Issue 6

 

Entire PDF Edition: http://mcs-america.org/june2009.pdf  (View, Download, and Print)
NEW!  Entire Online Edition: http://mcs-america.org/mcsanewsjune2009.htm   (View as a Webpage)

 

 

Direct Links to Articles Inside This Issue:

 

Governors and Mayors Warn of the Toxic Effects of Chemicals

PDF Version:      http://mcs-america.org/June2009pg12345.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Governors_and_Mayors

 

Social Security Disability   A Chink in the Armor

PDF Version:      http://mcs-america.org/June2009pg67.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Social_Security_

 

SAMe   Wonder Nutrient

PDF Version:      http://mcs-america.org/June2009pg89101112.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_SAMe__

 

The Prevalence of Fragrance Sensitivity

PDF Version:      http://mcs-america.org/June2009pg13.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_The_Prevalence_of

 

Welcome to MCS   Time to Look at Your Kitchen in a Different Light

PDF Version:      http://mcs-america.org/June2009pg141516.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Welcome_to_MCS

 

Bird, Bees, and Electromagnetic Pollution

PDF Version:      http://mcs-america.org/June2009pg171819.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Birds,_Bees,_and

 

The Impact of a Sweet Fragrance

PDF Version:      http://mcs-america.org/June2009pg20.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_The_Impact_of

 

Q&A   Public HVAC Scent Diffusers

PDF Version:      http://mcs-america.org/June2009pg21.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Proposed_Treatment_of

 

Q&A   Low Dose Antigens

PDF Version:      http://mcs-america.org/June2009pg22.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Fast_Metabolism_Linked

 

$3.3 Million Awarded in Mold Suit

PDF Version:      http://mcs-america.org/June2009pg23.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_$3.3_Million_Awarded

 

Vaccinated Children Three Times More Likely To Be Hospitalized

PDF Version:      http://mcs-america.org/June2009pg24.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Vaccinated_Children_Three

 

Irradiated Foods May Cause Serious Brain Damage

PDF Version:      http://mcs-america.org/June2009pg25.pdf 

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Irradiated_Foods_May

 

Patient Support and Resources

PDF Version:      http://mcs-america.org/June2009pg2627282930313233.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Resources_and_Support

 

Community News

PDF Version:      http://mcs-america.org/June2009pg34.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Community_News_4

 

Featured Research

PDF Version:      http://mcs-america.org/June2009pg353637.pdf

Online Version:  http://mcs-america.org/mcsanewsjune2009.htm#_Featured_Research_Studies_4

 

Multiple Chemical Sensitivities America
http://www.mcs-america.org admin@mcs-america.org

 

 

Copyrighted © 2008  MCS America

 

You have received this newsletter because you subscribed to it.

If you wish to unsubscribe, please send a message to unsubscribe@mcs-america.org.

 

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Friday, May 29, 2009

Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function.

Clin Sci (Lond). 2009 May 26. [Epub ahead of print]

Chronic fatigue syndrome: illness severity, sedentary lifestyle, blood volume and evidence of diminished cardiac function.

This study examined whether deficits in cardiac output and blood volume in a Chronic Fatigue Syndrome (CFS) cohort were present and linked to illness severity and sedentary lifestyle. Follow-up analyses assessed whether differences between CFS and control groups in cardiac output levels were corrected by controlling for cardiac contractility and total blood volume (TBV). The 146 participants were subdivided into two CFS groups based on symptom severity data, severe (n=30) vs. non-severe (n=26), and two healthy non-CFS control groups based on physical activity, sedentary (n=58) vs. non-sedentary (n=32). Controls were matched to CFS participants using age, sex, ethnicity and body mass. Echocardiographic measures indicated that the severe CFS participants displayed 10.2% lower cardiac volume (i.e., stroke index and end diastolic volume) and 25.1% lower contractility (velocity of circumferential shortening corrected by heart rate) than the control groups. Dual tag blood volume assessments indicated that CFS groups had lower TBV, plasma volume (PV) and red blood cell volume (RBCV) than control groups. Of the CFS subjects with a TBV deficit (i.e., >/=8% below ideal levels), the mean +/-SD percent deficit in TBV, PV and RBCV were 15.4+/-4.0, 13.2+/-5.0, and 19.1+/-6.3, respectively. Lower CFS cardiac volume levels were substantially corrected by controlling for prevailing TBV deficits, but were not affected by controlling for cardiac contractility. Analyses indicated that the TBV deficit explained 91-94% of the group differences in cardiac volume indices. Group differences in cardiac structure were offsetting and hence no differences emerged for LV mass index. Therefore, the findings indicate that lower cardiac volume levels, displayed primarily by persons with severe-CFS, were not linked to diminished cardiac contractility levels, but were likely a consequence of a comorbid hypovolemic condition. Further study is needed to address the extent to which the CFS cardiac and blood volume alterations have physiological and clinical significance.

PMID: 19469714 [PubMed - as supplied by publisher]

Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESS.

J Allergy Clin Immunol. 2009 May;123(5):1041-6. Epub 2009 Apr 10.

Relationships among prenatal aeroallergen exposure and maternal and cord blood IgE: project ACCESS.

Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA.

BACKGROUND: Whereas some evidence suggests that antigen sensitization may begin prenatally, the influence of maternal allergen exposure during pregnancy has not been fully elucidated. OBJECTIVES: We examined the relationship between prenatal maternal aeroallergen exposure and cord blood total IgE and the potential mediating/indirect effect of maternal immune response. METHODS: This study was performed in 301 mother-infant pairs enrolled in the Asthma Coalition on Community, Environment, and Social Stress (ACCESS) project, a study examining the effects of prenatal and early life social and physical environmental exposures on urban asthma risk. Dust samples collected prenatally from mothers' bedrooms were analyzed for cockroach and dust mite allergens. Cord blood was analyzed for total IgE, and maternal serum collected during pregnancy for total and specific IgE. We assessed the relationship between prenatal exposure and cord blood total IgE and the potential mediation effect adjusting for maternal age, race, education, smoking status, and dust collection season; and child's sex and season of birth. RESULTS: In multivariate models, elevated prenatal dust mite levels (>0.2 microg/g) increased cord blood IgE concentrations by 29% (P = .08), and continuous dust mite concentration was associated with a significant nonlinear increase in cord blood IgE (P = .02). Elevated prenatal exposure to cockroach allergen (>2 U/g) was not associated with cord blood IgE, but showed a significant indirect relationship through maternal total IgE (beta = 0.23; 95% CI, 0.08-0.41). CONCLUSION: These results demonstrate that maternal prenatal exposure to household allergens may affect cord blood IgE, albeit the underlying mechanism may be allergen-specific.

PMID: 19361844 [PubMed - indexed for MEDLINE]

Patients treated by tegaserod for irritable bowel syndrome with constipation showed significant improvement in fibromyalgia symptoms. A pilot study.

Clin Rheumatol. 2009 May 26. [Epub ahead of print]

Patients treated by tegaserod for irritable bowel syndrome with constipation showed significant improvement in fibromyalgia symptoms. A pilot study.

Rheumatology Unit, Barzilai Medical Center, Ashkelon, Israel.

The symptoms of irritable bowel syndrome (IBS) are commonly seen in fibromyalgia (FM) patients. This study aimed to evaluate the effect of 5-hydroxytryptamin-4 receptor partial agonist (tegaserod) on the symptoms of FM among the patients who receive the medicine because of IBS. Forty-one female patients with IBS and constipation, which were subjects to tegaserod treatment, were examined by rheumatologist and 14 were found to suffer from FM. The fibromyalgia impact questionnaire (FIQ) and clinical examination were done before tegaserod treatment and 1 month after. The IBS status, the total FIQ score, the number of tender points and pain in tender points were lowered significantly after the treatment (p < 0.001 for all variables). The results of this pilot study provide the preliminary evidence that FM patients can benefit from treatment by 5-hydroxytryptamin-4 receptor partial agonist. Additional studies are needed to support this conclusion.

PMID: 19468788 [PubMed - as supplied by publisher]

[Fibromyalgia prevalence in Tunisia]

Tunis Med. 2008 Sep;86(9):806-11.

[Fibromyalgia prevalence in Tunisia]

[Article in French]

Service de médecine physique et de réadaptation fonctionnelle CHU Habib Bourguiba, 3029 Sfax Tunisie.

OBJECTIVE: to estimate fibromyalgia (FM) prevalence in Tunisia. METHODS: Data on a cross-section of 1000 individuals aged 15 years or older living in Sfax were collected by interviewers using the London Fibromyalgia Epidemiology Study Screening Questionnaire (LFES- SQ). The sampling was realized by empirical poll and respecting quota according to delegation, rural or urban environment, sex and age according to the demographic national data. The positive screened subjects were invited to be examined to confirm or exclude the FM by applying the 1999 ACR criteria. The questionnaire was administered to a second group of 252 volunteers, all were afterward examined. This allowed to study specificity and sensibility of the questionnaire and allowed to calculate the FM prevalence. RESULTS: 159 subjects were screened positive, only 141 were examined. The specialized exam allowed confirming the diagnosis of FM in 67 subjects. FM prevalence is different according to sex, age, study level and socio-economic level. Two hundred and fifty two volunteers answered the questionnaire then all examined. The questionnaire specificity was 90.8% and the sensibility 79.4%. FM prevalence in Tunisia, calculated by Bayes theorem, is estimated between 8.27% and 12.3%. CONCLUSION: FM prevalence in Tunisia is estimated at least at 8.27%.

PMID: 19472780 [PubMed - in process]

Wednesday, May 27, 2009

Point-of-Sale Printers May Trigger Asthma

Point-of-Sale Printers May Trigger Asthma

 
Chemical on receipts, coupons, tickets the likely culprit, report suggests

Testing for Treatable Chemical Injury

Monday, May 25, 2009

A National Study of Residential Pesticides Measured from Floor Wipes

American Healthy Homes Survey: A National Study of Residential Pesticides Measured from Floor Wipes
http://pubs.acs.org/doi/abs/10.1021/es8030243

The U.S. Department of Housing and Urban Development in collaboration with the United States Environmental Protection Agency conducted a survey measuring lead, allergens, and insecticides in a randomly selected nationally representative sample of residential homes. Multistage sampling with clustering was used to select the 1131 homes of which a subset of 500 randomly selected homes included the collection of hard surface floor wipes. Samples were collected by trained field technicians between June 2005 and March 2006 using isopropanol wetted wipes.

Samples were analyzed for a suite of 24 compounds which included insecticides in the organochlorine, organophosphate, pyrethroid and phenylpyrazole classes, and the insecticide synergist piperonyl butoxide.

The most commonly detected were permethrin (89%), chlorpyrifos (78%), chlordane (64%), piperonyl butoxide (52%), cypermethrin (46%), and fipronil (40%). Mean and geometric mean (GM) concentrations varied widely among compounds, but were highest for trans-permethrin (mean 2.22 ng/cm2 and GM 0.14 ng/cm2) and cypermethrin (mean 2.9 ng/cm2 and GM 0.03 ng/cm2).

Results show that most floors in occupied homes in the U.S. have measurable levels of insecticides that may serve as sources of exposure to occupants.

Daniel M. Stout II*†, Karen D. Bradham†, Peter P. Egeghy†, Paul A. Jones†, Carry W. Croghan†, Peter A. Ashley‡, Eugene Pinzer‡, Warren Friedman‡, Marielle C. Brinkman§, Marcia G. Nishioka§ and David C. Cox
National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Office of Healthy Homes and Lead Hazard Control, U.S. Department of Housing and Urban Development, 451 seventh Street, SW, Washington, D.C. 20410, Battelle Memorial Institute, 505 King Avenue, Columbus, Ohio 43201, Quantech, 2020 N 14th St, Suite 41,0 Arlington, Virginia 22201
Environ. Sci. Technol., Article ASAP
Publication Date (Web): May 6, 2009
Copyright © 2009 American Chemical Society
* Corresponding author phone: (919) 541-5767; fax: (919) 541-0905; e-mail: stout.dan@epa.gov.

MCS Awareness Month

MCS Awareness Month
http://www..holistichelp.net/blog/mcs-awareness-month/

May is MCS, aka multiple chemical sensitivity, awareness month. Many of you may not be aware that this is a deeply personal issue for me, because I live with severe and disabling MCS. So this is a topic that I have a great deal of not only professional experience, but personal as well.

Despite the fact that more than 48 million Americans have some degree of chemical sensitivity, of which about 3 million are full blown MCS, it continues to be a condition that many people are unaware of and don't understand.

MCS is short for multiple chemical sensitivity and is sometimes called environmental illness syndrome or more recently chemical injury. The term chemical injury was coined in an attempt to find a better term that more accurately describes the condition. As anyone living with MCS knows, the term "sensitivity" really doesn't capture the essence of what this condition means. To some degree it really minimizes it and covers up the fact, which is that chemicals have injured the person inflicted, so therefore chemical injury is a much more accurate term. However, since most people continue to use the term MCS and it is the term that most people are aware of, we will continue to use it in this post.
 
<snip>  See link for full article.

Friday, May 22, 2009

Respiratory morbidity and medical visits associated with dampness and air-conditioning in offices and homes.

Indoor Air. 2009 Feb;19(1):58-67. Epub 2008 Dec 2.Click here to read LinkOut

Respiratory morbidity and medical visits associated with dampness and air-conditioning in offices and homes.

Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV 26505, USA. nsahakian@cdc.gov

We used data from 4345 adult US residents who were part of a 2004 national random mail survey to investigate associations between dampness and air-conditioning (AC) in homes and offices, and health outcomes, sick leave due to respiratory symptoms and medical visits during the past 12 months. We identified from this group 1396 office workers employed in professional, executive, administrative, managerial or administrative support occupations. Office workers reporting home dampness had an elevated prevalence of nasal symptoms [prevalence ratio (PR) = 1.4, P = 0.01] and constitutional symptoms (PR = 1.3, P = 0.01) in the previous year. Office workers reporting workplace dampness had an elevated prevalence of sick leave attributed to respiratory symptoms (PR = 1.3, P = 0.04) in the previous year. Office workers with home AC were more likely to have visited a medical specialist in the previous year (PR = 1.3, P = 0.02). We did not find any statistically significant associations between workplace AC and any of the health outcomes. We estimated an annual cost of US$1.4 billion for excess respiratory-related sick leave among office workers with workplace dampness. Our study strengthens the evidence of a relationship between dampness and health effects, and highlights the resulting economic impact. PRACTICAL IMPLICATIONS: This study adds to the literature on respiratory morbidity associated with home and office exposures to mold and dampness. Public health response to lessen these exposures will improve the health and well-being of residents and workers as well as diminish the economic burden of lost work time and medical costs.

PMID: 19076249 [PubMed - indexed for MEDLINE]

[Evaluation of urinary cortisol levels in women with Fibromyalgia.]

Med Clin (Barc). 2009 May 18.
 
[Evaluation of urinary cortisol levels in women with Fibromyalgia.]
[Article in Spanish]

Servicio de Bioquímica Clínica, Hospital Universitario Miguel Servet, Zaragoza, España.

OBJECTIVE: We propose a comparative study of urinary cortisol in a controlled simple group of patients diagnosed with fibromyalgia (FM) during a minimum time frame (3 years) vs. a normal group with the same characteristics of age and gender. Our objective is to demonstrate if urinary cortisol at lower levels than those found in the normal population, as long as FM is regarded, could help to evaluate the fatigue. METHODS: We determined the urinary cortisol in a group of 47 women with a clinical diagnosis of FM using the criteria from the American College of Rheumatology (ACR) 1990, with ages between 29 and 64 years, in whom an accurate sample was collected and cortisol was determined using an FPIA method. The results were compared with the urinary cortisol obtained in a group of 88 healthy women within the same age range as those with FM. RESULTS: Urinary cortisol in FM was 65.0mug/l (median), which was significantly lower than that of the healthy group (80.0mug/l), p<0.001. CONCLUSION: 33.4% of patients with FM displayed urinary cortisol concentrations significantly lower than the group of women without FM.

PMID: 19457504 [PubMed - as supplied by publisher]

Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses.

J Intern Med. 2009 May 19. [Epub ahead of print]Click here to read

Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses.

From the UMR MD2 (P2COE); and IFR Jean Roche, Faculté de Médecine, Université de la Méditerranée and Pulmonary Function Laboratory, North Hospital, Assistance Publique - Hôpitaux de Marseille, France.

Abstract. Jammes Y, Steinberg JG, Delliaux S, Brégeon F (Université de la Méditerranée and Pulmonary Function Laboratory, North Hospital, Assistance Publique - Hôpitaux de Marseille, France). Chronic fatigue syndrome combines increased exercise-induced oxidative stress and reduced cytokine and Hsp responses. J Intern Med 2009; doi: 10.1111/j.1365-2796.2009.02079.xObjectives. As heat shock proteins (Hsp) protect the cells against the deleterious effects of oxidative stress, we hypothesized that Hsp expression might be reduced in patients suffering from chronic fatigue syndrome (CFS) who present an accentuated exercise-induced oxidative stress. Design. This case-control study compared nine CFS patients to a gender-, age- and weight-matched control group of nine healthy sedentary subjects. Interventions. All subjects performed an incremental cycling exercise continued until exhaustion. We measured ventilation and respiratory gas exchange and evoked compound muscle potential (M-wave) recorded from vastus lateralis. Repetitive venous blood sampling allowed measurements of two markers of oxidative stress [thiobarbituric acid reactive substances (TBARS) and reduced ascorbic acid (RAA)], two cytokines (IL-6 and TNF-alpha) and two Hsp (Hsp27 and Hsp70) at rest, during maximal exercise and the 60-min recovery period. Results. Compared with controls, resting CFS patients had low baseline levels of RAA and Hsp70. Their response to maximal exercise associated (i) M-wave alterations indicating reduced muscle membrane excitability, (ii) early and accentuated TBARS increase accompanying reduced changes in RAA level, (iii) absence of significant increase in IL-6 and TNF-alpha, and (iv) delayed and marked reduction of Hsp27 and Hsp70 variations. The post-exercise increase in TBARS was accentuated in individuals having the lowest variations of Hsp27 and Hsp70. Conclusions. The response of CFS patients to incremental exercise associates a lengthened and accentuated oxidative stress, which might result from delayed and insufficient Hsp production.

PMID: 19457057 [PubMed - as supplied by publisher]

Solid-phase microextraction gas chromatography-mass spectrometry determination of fragrance allergens in baby bathwater.

Anal Bioanal Chem. 2009 May 21. [Epub ahead of print]

Solid-phase microextraction gas chromatography-mass spectrometry determination of fragrance allergens in baby bathwater.

Departamento de Quimica Analitica, Nutricion y Bromatologia, Facultad de Quimica, Instituto de Investigacion y Analisis Alimentario, Campus Sur, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain.

A method based on solid-phase microextraction (SPME) and gas chromatography-mass spectrometry (GC-MS) has been optimized for the determination of fragrance allergens in water samples. This is the first study devoted to this family of cosmetic ingredients performed by SPME. The influence of parameters such as fibre coating, extraction and desorption temperatures, salting-out effect and sampling mode on the extraction efficiency has been studied by means of a mixed-level factorial design, which allowed the study of the main effects as well as two-factor interactions. Excluding desorption temperature, the other parameters were, in general, very important for the achievement of high response. The final procedure was based on headspace sampling at 100 degrees C, using polydimethylsiloxane/divinylbenzene fibres. The method showed good linearity and precision for all compounds, with detection limits ranging from 0.001 to 0.3 ng mL(-1). Reliability was demonstrated through the evaluation of the recoveries in different real water samples, including baby bathwater and swimming pool water. The absence of matrix effects allowed the use of external standard calibration to quantify the target compounds in the samples. The proposed procedure was applied to the determination of allergens in several real samples. All the target compounds were found in the samples, and, in some cases, at quite high concentrations. The presence and the levels of these chemicals in baby bathwater should be a matter of concern.

PMID: 19458938 [PubMed - as supplied by publisher]

Pituitary response to metyrapone in Gulf War veterans: Relationship to deployment, PTSD and unexplained health symptoms.

Psychoneuroendocrinology. 2009 May 13. [Epub ahead of print]Click here to read LinkOut

Pituitary response to metyrapone in Gulf War veterans: Relationship to deployment, PTSD and unexplained health symptoms.

Departments of Psychiatry, James J. Peters VA Medical Center, Bronx, NY, United States; Mount Sinai School of Medicine, New York, NY, United States.

OBJECTIVE: Gulf War deployment has been associated with a distinct neuroendocrine profile characterized by low 24h basal ACTH levels and enhanced cortisol and ACTH suppression to low-dose dexamethasone. The metyrapone stimulation test was performed to further characterize hypothalamic-pituitary activity in Gulf War veterans (GWV) and its relationship to unexplained medical symptoms and post-traumatic stress disorder (PTSD). METHOD: Eleven GWV without PTSD, 18 GWV with PTSD and 15 healthy subjects not exposed to the Gulf War theater (non-exposed) underwent the metyrapone stimulation test, which inhibits cortisol synthesis, impairs cortisol-mediated negative feedback inhibition and in turn increases levels of ACTH and 11-deoxycortisol, a cortisol precursor. These hormones were measured at baseline (7:00 a.m.) and at intervals (from 8:00 a.m. to 4:00 p.m.) following the administration of metyrapone 750mg orally at 7:05 a.m. and at 10:05 a.m. RESULTS: There were group differences in the ACTH response despite similar cortisol and 11-deoxycortisol responses to metyrapone. GWV without PTSD had a significantly attenuated ACTH response compared to non-exposed subjects; GWV with PTSD had a significantly higher ACTH response than GWV without PTSD but did not differ from non-exposed subjects. Among GWV, unexplained medical health symptoms (e.g., neurological, musculoskeletal, cardiac, and pulmonary symptoms) and PTSD symptoms were significantly positively associated with the ACTH response to metyrapone. CONCLUSION: Gulf War deployment is associated with a substantially lower ACTH response to metyrapone. In contrast, unexplained health symptoms and PTSD in Gulf War veterans are associated with relatively greater hypothalamic-pituitary activity which may reflect increased CRF activity and is evident only in consideration of deployment effects. This pattern of differences suggests either that Gulf War deployment and its associated exposures results in enduring changes in pituitary function or that reduced hypothalamic-pituitary activity protects against the development of PTSD and other deployment-related health problems.

PMID: 19446401 [PubMed - as supplied by publisher]

Phenotypes of individuals affected by airborne chemicals in the general population.

Int Arch Occup Environ Health. 2009 Mar;82(4):509-17. Epub 2008 Aug 28.

Phenotypes of individuals affected by airborne chemicals in the general population.

The Danish Research Centre for Chemical Sensitivities, Gentofte Hospital, University of Copenhagen, Ledreborg Allé 40, Gentofte, Denmark. nidrbe01@geh.regionh.dk

OBJECTIVE: To characterise the chemical exposures and symptoms affecting individuals with subsequent adjustments of social life or occupational conditions, and further characterise these severely affected individuals. METHODS: All individuals (n = 1,134) who reported symptoms from airborne chemical exposures in a population-based questionnaire study of 6,000 individuals were included and dichotomised according to severity. Logistic regression models were used to characterise the group of severely affected individuals. RESULTS: Severely affected individuals reported more symptoms and exposures related to symptoms than less severely affected individuals, and the number of symptoms was more predictive for severity than the number of exposures. Most predictive for the severity of reported symptoms were CNS-symptoms other than headache (OR = 3.2, P < 0.001) and exposure to freshly printed papers or magazines (OR = 2.0, P = 0.001). CONCLUSION: CNS-symptoms except from headache were a main characteristic of individuals severely affected by common chemical exposures in a general population-based sample.

PMID: 18751996 [PubMed - indexed for MEDLINE]

General practitioners' experiences with provision of healthcare to patients with self-reported multiple chemical sensitivity.

Scand J Prim Health Care. 2009 May 18:1-5. [Epub ahead of print]

General practitioners' experiences with provision of healthcare to patients with self-reported multiple chemical sensitivity.

Department of Dermatology, the Danish Research Centre for Chemical Sensitivities, Gentofte Hospital, University of Copenhagen.

Objective. To describe general practitioners' (GPs') evaluation of and management strategies in relation to patients who seek medical advice because of multiple chemical sensitivity (MCS). Design. A nationwide cross-sectional postal questionnaire survey. The survey included a sample of 1000 Danish GPs randomly drawn from the membership list of GPs in the Danish Medical Association. Setting. Denmark. Results. Completed questionnaires were obtained from 691 GPs (69%). Within the last 12 months 62.4% (n=431) of the GPs had been consulted by at least one patient with MCS. Of these, 55.2% of the GPs evaluated the patients' complaints as chronic and 46.2% stated that they were rarely able to meet the patients' expectations for healthcare. The majority, 73.5%, had referred patients to other medical specialties. The cause of MCS was perceived as multi-factorial by 64.3% of the GPs, as somatic/biologic by 27.6%, and as psychological by 7.2%. Partial or complete avoidance of chemical exposures was recommended by 86.3%. Clinical guidelines, diagnostic tools, or more insight in the pathophysiology were requested by 84.5% of the GPs. Conclusion. Despite the lack of formal diagnostic labelling the patient with MCS is well known by GPs. The majority of the GPs believed that MCS primarily has a multi-factorial explanation. However, perceptions of the course of the condition and management strategies differed, and many GPs found it difficult to meet the patients' expectations for healthcare. The majority of the GPs requested more knowledge and clinical guidelines for the management of this group of patients.

PMID: 19452353 [PubMed - as supplied by publisher

Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder.

 J Pain. 2009 May;10(5):542-52.Click here to read Links

Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder.

http://www.ncbi.nlm.nih.gov/pubmed/19411061

Health Sciences Center, University of Utah, Salt Lake City, Utah, USA. Kathleen.C.Light@hsc.utah.edu

In patients with fibromyalgia syndrome (FMS) and temporomandibular disorder (TMD), stress and pain may chronically enhance sympathetic activity, altering cardiovascular responses and worsening pain. This study examined cardiovascular, epinephrine (EPI), norepinephrine (NE), cortisol and clinical pain responses in 54 female patients with these disorders and 34 controls. In a subsample of 10 FMS, 10 TMD patients and 16 controls, using a counterbalanced, double-blind, crossover design, the same responses were assessed after intravenous administration of low dose propranolol vs placebo. Testing included baseline, postural, speech and ischemic pain stressors. FMS patients showed lesser heart rate (HR) increases to posture challenge but greater blood pressure (BP) increases to postural and speech tasks than controls, as well as higher overall BP and greater total vascular resistance (TVR) than TMDs or controls. TMDs showed higher overall cardiac output and lower TVR than controls. Both FMS and TMD groups showed lower baseline NE than controls, and TMDs showed lower overall EPI and NE levels. Group differences in HR, EPI and NE were abolished after propranolol although BP, CO and TVR differences persisted. In both FMS and TMD, the number of painful body sites and ratings of total clinical pain obtained 4 times during each session were significantly lower after beta-blockade vs placebo. PERSPECTIVE: These findings support the hypothesis that both FMS and TMD may frequently involve dysregulation of beta-adrenergic activity that contributes to altered cardiovascular and catecholamine responses and to severity of clinical pain. Acute treatment with low-dose propranolol led to short-term improvement in all these domains.

PMID: 19411061 [PubMed - in process]

An Investigation into the Cognitive Deficits Associated with Chronic Fatigue Syndrome

Open Neurol J. 2009; 3: 13–23.
Published online 2009 February 27. doi: 10.2174/1874205X00903010013.PMCID: PMC2682840

An Investigation into the Cognitive Deficits Associated with Chronic Fatigue Syndrome

Marie Thomas*1,2 and Andrew Smith1

1Centre for Occupational and Health Psychology, School of Psychology, Cardiff University, UK
2Centre for Health Information Research Evaluation, School of Medicine, Swansea University, UK
*Address correspondence to this author at the Centre for Health Information Research Evaluation, School of Medicine, Swansea University, UK; E-mail: Marie.A.Thomas@swansea.ac.uk
Received June 14, 2008; Revised September 27, 2008; Accepted November 16, 2008.

This study addresses, among other things, the debate as to whether cognitive deficits do occur with a diagnosis of Chronic Fatigue Syndrome (CFS). Previous studies have indicated a potential mismatch between subjective patient ratings of impairment and clinical assessment. In an attempt to tackle some of the methodological problems faced by previous research in this field, this study recruited a large sample of CFS patients where adequate diagnosis had been made and administered an extensive battery of measures. In doing so this study was able to replicate previous published evidence of clear cognitive impairment in this group and demonstrate also that these deficits occurred independent of psychopathology. The conclusion drawn is that cognitive impairments can be identified if appropriate measures are used. Furthermore, the authors have shown that performance changes in these measures have been used to assess both efficacy of a treatment regime and rates of recovery.

Thursday, May 21, 2009

Reduced glutathione regenerating enzymes undergo developmental decline and sexual dimorphism in the rat cerebral cortex.

Brain Res. 2009 May 15. [Epub ahead of print]Click here to read Links

Reduced glutathione regenerating enzymes undergo developmental decline and sexual dimorphism in the rat cerebral cortex.

http://www.ncbi.nlm.nih.gov/pubmed/19450567?ordinalpos=9&itool=Email.EmailReport.Pubmed_ReportSelector.Pubmed_RVDocSum

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy and Biomedical Research Institute, Idaho State University, Pocatello, Idaho 83209-8334; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, Kentucky 40536-0509.

Oxidative stress during development may predispose humans to neurodegenerative disorders in old age. Moreover, numerous ailments of brain disproportionately affect one of the genders. We therefore hypothesized that, activities of enzymes regenerating and utilizing glutathione (GSH) show sexual dimorphism and developmental differences in rat brain. To test this hypothesis, we collected cortex tissue from male and female Sprague-Dawley rats at post-natal day (PN) 5, PN 10, PN 20, PN 30, and PN 60. We measured tissue levels of NADP-linked isocitrate dehydrogenase (NADP-ICDH), glucose-6-phosphate dehydrogenase (G6PDH), and, glutathione reductase (GR) by UV spectrophotometry and determined glutathione peroxidase (GPx) expression therein by western blotting. Our results showed that sexual maturation had an impact on activities of enzymes that regenerate and utilize GSH and rat female cortex had more anti-oxidant capacity. Moreover, age-related decline in the activities of these key enzymes were observed. Reduced glutathione and NADPH protects the brain from oxidative stress. Thus, our results may have implications for neurodegenerative disorders like Parkinson's disease and developmental disorders of brain like autism in which oxidative stress plays a key role.

PMID: 19450567 [PubMed - as supplied by publisher]

Monday, May 18, 2009

WEBINAR: Protecting Children from Environmental Risks at Home and in Child Care Settings

 

 

Upcoming Webinar

Wednesday,
May 20, 2009

11 a.m.-12:30 p.m. Eastern
(8-9:30 a.m. Pacific)


Protecting Children from Environmental Risks at Home and in Child Care Settings

http://www.icfi.com/markets/social-programs/eei-webinar-may09.asp

Representatives from the U.S. Environmental Protection Agency (EPA) will share valuable information about how the early child care community can create healthy and safe settings by reducing various environmental risks in the child care setting and family homes that threaten children's health.

 

Continuous exposure to 900MHz GSM-modulated EMF alters morphological

Neurosci Lett. 2009 May 22;455(3):173-7.
Epub 2009 Mar 24

Continuous exposure to 900MHz GSM-modulated EMF alters morphological
maturation of neural cells.

http://www.ncbi.nlm.nih.gov/pubmed/19429115

Del Vecchio G, Giuliani A, Fernandez M, Mesirca P, Bersani F, Pinto R,
Ardoino L, Lovisolo GA, Giardino L, Calzà L.
BioPharmaNet-DIMORFIPA, Bologna University, Bologna, Italy.

The effects of radiofrequency electromagnetic field (RF-EMF) exposure
on neuronal phenotype maturation have been studied in two different in
vitro models: murine SN56 cholinergic cell line and rat primary
cortical neurons. The samples were exposed at a dose of 1W/kg at 900
MHz GSM modulated. The phenotype analysis was carried out at 48 and 72
h (24 and 48 h of SN56 cell line differentiation) or at 24, 72, 120 h
(2, 4 and 6 days in vitro for cortical neurons) of exposure, on live
and immunolabeled neurons, and included the morphological study of
neurite emission, outgrowth and branching. Moreover, cortical neurons
were studied to detect alterations in the expression pattern of
cytoskeleton regulating factors, e.g. beta-thymosin, and of early
genes, e.g. c-Fos and c-Jun through real-time PCR on mRNA extracted
after 24h exposure to EMF. We found that RF-EMF exposure reduced the
number of neurites generated by both cell systems, and this alteration
correlates to increased expression of beta-thymosin mRNA.

Mitochondrial dysfunction, impaired oxidative-reduction activity, degeneration, and death in human neuronal and fetal cells induced by low-level exposure to thimerosal and other metal compounds

Mitochondrial dysfunction, impaired oxidative-reduction activity, degeneration, and death in human neuronal and fetal cells induced by low-level exposure to thimerosal and other metal compounds
http://www.informaworld.com/smpp/content~content=a910652305~db=all~jumptype=rss

D.A. Geier et al.

Toxicological & Environmental Chemistry
2009, 1–15, iFirst

Thimerosal (ethylmercurithiosalicylic acid), an ethylmercury (EtHg)-releasing compound (49.55% mercury (Hg)), was used in a range of medical products for more than 70 years. Of particular recent concern, routine administering of Thimerosal-containing biologics/childhood vaccines have become significant sources of Hg exposure for some fetuses/infants. This study was undertaken to investigate cellular damage among in vitro human neuronal (SH-SY-5Y neuroblastoma and 1321N1 astrocytoma) and fetal (nontransformed) model systems using cell vitality assays and microscope-based digital image capture techniques to assess potential damage induced by Thimerosal and other metal compounds (aluminum (Al) sulfate, lead (Pb)(II) acetate, methylmercury (MeHg) hydroxide, and mercury (Hg)(II) chloride) where the cation was reported to exert adverse effects on developing cells. Thimerosal-associated cellular damage was also evaluated for similarity to pathophysiological findings observed in patients diagnosed with autistic disorders (ADs). Thimerosal-induced cellular damage as evidenced by concentration- and time-dependent mitochondrial damage, reduced oxidative–reduction activity, cellular degeneration, and cell death in the in vitro human neuronal and fetal model systems studied. Thimerosal at low nanomolar (nM) concentrations induced significant cellular toxicity in human neuronal and fetal cells. Thimerosal-induced cytoxicity is similar to that observed in AD pathophysiologic studies. Thimerosal was found to be significantly more toxic than the other metal compounds examined. Future studies need to be conducted to evaluate additional mechanisms underlying Thimerosal-induced cellular damage and assess potential co-exposures to other compounds that may increase or decrease Thimerosal-mediated toxicity.

Sunday, May 17, 2009

MAY ACTIVISM: Environmental MCS/EMS Emblems

Make a difference today!Wear an environmental Emblem!
http://www.collectionsofgifts.com/mcs.html

These emblems are stunningly beautiful, and are the symbol of our mission of
Environmental Awareness on this Earth!

Poster has no financial interest.

Governors and Mayors Warn of the Health Effects of Toxic Substances in Everyday Products

*Permission to Forward
 
Governors and Mayors Warn of the Health Effects of Toxic Substances in Everyday Products
 
May 16, 2009
Lourdes Salvador
 
In the United States alone, it is estimated that more than over 48 million men, women, and children suffer adverse health reactions to everyday chemicals.

Toxic chemical injury is an increasing epidemic which leads to emergency department visits, job loss, homelessness, school absenteeism, and serious lifelong chronic illness in America.

Multiple chemical sensitivity (MCS) affects men, women, and children irregardless of gender, race and economic status. Children are especially vulnerable during development and due to their smaller size.

In response to these alarming statistics, and in an effort to raise public awareness of the risks faced everyday by Americans living with multiple chemical sensitivity and toxic injury, May is Multiple Chemical Sensitivity and Toxic Injury Awareness Month in America.

Thirty-six governors and mayors across America have already issued proclamations for this important event and more are still pouring in.

Events are held across the United States during May. Each event raises awareness about indoor and outdoor pollutants that trigger multiple chemical sensitivity and toxic injury, as well as ways to prevent toxic injuries and exposures.

Vast efforts have been made by politicians, individuals, and organizations around the world to expand awareness.

Governors and Mayors Speak Out

Many governors and mayors around the country have proclaimed May as Toxic Injury, Multiple Chemical Sensitivity, and Electromagnetic Sensitivity Awareness month.

Jodi Rell, governor of Connecticut, recognized all three and said, "Multiple Chemical Sensitivity is a preventable disorder... a chronic condition for which there is no cure... recognized by the Americans with Disabilities Act, Social Security Administration, World Health Organization, United States Department of Housing and Urban Development, and other state and national government agencies and commissions."

Rell, along with governors Christine O. Gregoire of Washington, Mayor Thomas P. Perciak of Strongsville Ohio, and others say, "Reasonable accommodations, information about, and recognition of MCS can enable people with MCS to enjoy access to work, schooling, public facilities, and other settings where they can continue to contribute their skills, ideas, creativity, abilities, and knowledge."

Arizona governor Janice K. Brewer informs citizens that, "Toxic substances can cause harmful effect characterized by heightened sensitivity to very small amounts of air pollution, petrochemicals, and other toxins found in our everyday products and environment."

Florida Governor Charlie Crist reminds us that we are all at risk from common chemical exposures when he says, "The health of the general population is at risk from chemical exposures that can lead to this environmentally induced illness." Crist also reminds us that MCS may be preventable through the reduction or avoidance of chemicals in our air, food, water, and indoor/outdoor environments.

Rell also affirms, "The health of the general population is at risk from electromagnetic exposures that can lead to this illness induced by electromagnetic radiation."

The Environmental Working Group has conducted studies which confirm that dozens of chemicals in products we use every day enter the blood of test subjects. These chemicals include flame retardants from furniture and bedding; pesticides from food crops, home use, and commercial applications; heavy metals from food contamination, thermometers, switches, and coal fired power plants; formaldehyde from clothing treatments and other sources; and an assorted chemical cocktail of the nearly 5,000 chemicals which create fragrances that are added to our personal care products, perfumes, soaps, air fresheners, and other scented items.

Few of these chemicals are tested for human safety, despite widespread belief to the contrary. None of them have been tested for synergistic effects in combination.

Brewer states, "Toxic substances may cause multiple illnesses affecting all parts of the body, including the respiratory, central nervous, and immune systems."

Brian Schweitzer, governor of Montana, agrees, "Preventing exposure to harmful chemicals is critical in protecting public health and safety. Reducing of hazardous chemicals in our environment can help eliminate MCS and EI (environmental illnesses)."

Dave Freudenthal, governor of Wyoming, issues another important reminder that toxic injury, "may include multiple often disabling illness and can be life threatening."

Individual proclamations may be viewed at: http://www.mcs-america.org/index_files/proclamations.htm.

Ohio Senators Dale Miller (D-Cleveland) and Kevin Coughlin (R-Cuyahoga Falls) have gone one step further with the introduction of Senate Bill No. 117 which would designate May as MCS Awareness Month in Ohio on an annual basis under the law. This differs from ordinary proclamations which are issued one year at a time. Ohio Senate Bill No. 117 may be viewed at: http://www.legislature.state.oh.us/BillText128/128_SB_117_I_Y.pdf.

Thirty-six governors and 30 mayors also issued Environmental Education Week proclamations stressing the value of and need for environmental education in their states and cities. For more information, visit the Children's Environmental Health Network: Environmental Education Week at http://www.eeweek.org/.

Personal Choices

The choices we make as consumers largely govern manufacturers revenues and, hence, the products they choose to market. It is within the power of each of us to select the safest products on the market and let sellers know we want safer ones. To do this, we must educate ourselves at every opportunity and question every claim.

An interesting paradigm exists around marketing. Much advertising is geared toward convincing buyers that it is essential to have and use a product. In reality, many of these ploys are gimmicks to sell unnecessary and often unsafe products.

Clever twists on a scientific study in which it was declared that an office keyboard had more germs on it than a public toilet put fear in millions of people and sold huge amounts of disinfectant spray that made many people ill through the unintentional poisoning office air. Secretaries and staff applied copious amounts of disinfectant to prevent the spread of germs based on this fictitious study claim.

Yet, when this study was examined more closely, it was found that the public toilet in question was cleaned and sanitized daily by a janitor while the keyboard had not been so much as wiped, let alone actually cleaned, in years. The fact remains that if both were cleaned with simple soap and water on a regular basis, the keyboard would have few germs and the toilet would look like germ warfare in comparison. Studies have shown that soap and water works as effectively as anti-bacterial products at reducing germs... without the toxic effects.

Unfortunately, most consumers have been raised to believe what they are told. We trust that we are given accurate information without bias and few think about the biased financial interests of advertisers. This begins at a very early age and advertising is often geared towards children and young adults at a time when they are most impressionable. Few have the knowledge, skill, or understanding to research the claims that advertisers make.

Spreading the Word

The Allergy and Environmental Sensitivity Support and Research Association, Inc. held a Chemical Sensitivity 2009 Seminar in Australia on May 15, 2009. Speaking at the seminar were medical, legal and architectural experts who discussed chemical sensitivity and its impacts on the lives of sufferers and family.

The seminar flyer may be downloaded from: http://www.mcs-america.org/AESSRAChemicalSensitivty09Seminar.pdf.

A press release can be found at: http://www.mcs-america.org/ChemicalSensitivitySeminar2009PressRelease.pdf.

The Allergy and Environmental Sensitivity Support and Research Association, Inc. also distributed a brochure called "Are You Sensitive to Chemicals?" It may be found at: http://www.mcs-america.org/areyousensitivetochemicals.pdf.

In Florida, Christiane Tourtet, Founder and President of International MCS/EMS Awareness, arranged for Observance of multiple chemical sensitivity and electromagnetic sensitivity through a library display at the LeRoy Collins Leon County Library in Tallahassee, Florida. Photographs may be found at: http://www.nettally.com/prusty/Formww.htm.

In Parma Heights, Ohio, seminars were presented in collaboration with the Ohio Network for the Chemically Injured on various topics. They included:

Eating Green with Jeff Heinen http://www.cuyahogalibrary.org/EventDetail.aspx?EventInstanceID=32707 Wednesday, May 13, 2009 7:00 PM

The Environment and Your Health http://www.cuyahogalibrary.org/EventDetail.aspx?EventInstanceID=32705 Wednesday, May 06, 2009 7:00 PM

The University of New Mexico Center for Development and Disability has issued their Third Edition of Tips for First Responders.

According to publishers, "Tips for First Responders, a 14-page, color-coded, laminated 4.5 x 5.5-inch field guide. For the third edition a tip sheet has been added that offers information to first responders on how to assist Childbearing Women and Newborns. Tips also include persons with a wide range of disabilities, as well as Seniors, People with Service Animals, People with Mobility Challenges, People with Mental Illness, Blind or Visually Impaired People, Deaf or Hard of Hearing People, People with Autism, People with Multiple Chemical Sensitivities and People with Cognitive Disabilities.

The tip sheets provide information first responders can use during emergencies as well as routine encounters. They are not meant to be
comprehensive, but contain specific information that you can read quickly either before or while responding to an incident. Over 80,000 copies of the tips have been ordered by first responders across the country.

Partners in developing the Tip Sheets include the Bureau of Health Emergency Management, New Mexico Department of Health; the New Mexico Governor's Commission on Disability; the American Association on Health and Disability; and the Disability and Health Branch of the Centers for Disease Control and Prevention."

The PDF Version of the Tips for First Responders may be viewed at http://cdd.unm.edu/products/tips3rdedition.pdf.

The Tips for First Responders order form for printed copies may be downloaded from http://cdd.unm..edu/products/TIPSheetOrderForm.pdf.

Most people spend approximately 60% of their time indoors according to the Allergy and Environmental Sensitivity Support and Research Association Inc. (AESSRA) on a recent radio show, "Trends and Products: our worsening indoor air". "As we move to conserve energy in our houses we often need to close off the house -- but this means less air flow and more potential for a poor quality of indoor air, " according to the AESSRA. For more information and to listen to the show, see http://www.abc.net.au/rn/bydesign/stories/2009/2562183.htm.

Statistics

MCS America reminds us of several important statistics related to MCS in their press release http://www..americanchronicle.com/articles/view/100998.

MCS is a Major Public Health Concern
-At least 45 million people in the US report sensitivity to various chemicals.
-About 3 million Americans are diagnosed with MCS.
-MCS affects people of all ages, economic status, race, and both genders.
-Chemicals that people with MCS react to are toxic and affect everyone to some extent.

Medical Findings
-Brain scans show reduced blood flow to the brain when people with MCS are under chemical exposure.
-Physical variances identified in MCS include brain inflammation, oxidative stress, excitotoxicity, cardiac and airway disease, and auto-immune disorders.
-Mast cell activation and disorders of porphyrin metabolism have been linked to MCS.
-Genetic variations relating to detoxification processes have been linked to MCS.

The Cost of Environmental Illnesses
-Annual expenditures for healthcare and lost productivity due to MCS are estimated at $71.8 billion dollars per year.

Environmental Factors
-Indoor and outdoor environmental exposures can trigger reactions: perfumes and fragrances, cleaning solutions, scented laundry products, pesticides, herbicides, paint and building materials, gasoline and petroleum based products, artificial flavors, colors, and preservatives.

MCS Can be Controlled
-MCS can be controlled with a plan that includes avoidance and control of environmental triggers; many people with MCS can lead normal, healthy, and active lives.

For more articles information on this topic, see: MCS America http://mcs-america.org and MCSA News http://mcs-america.org/index_files/newsletterarchives.htm.

Copyrighted 2009 Lourdes Salvador & MCS America
 

Saturday, May 16, 2009

Chronic fatigue syndrome and mitochondrial dysfunction.

Int J Clin Exp Med. 2009;2(1):1-16. Epub 2009 Jan 15.

Chronic fatigue syndrome and mitochondrial dysfunction.

This study aims to improve the health of patients suffering from chronic fatigue syndrome (CFS) by interventions based on the biochemistry of the illness, specifically the function of mitochondria in producing ATP (adenosine triphosphate), the energy currency for all body functions, and recycling ADP (adenosine diphosphate) to replenish the ATP supply as needed. Patients attending a private medical practice specializing in CFS were diagnosed using the Centers for Disease Control criteria. In consultation with each patient, an integer on the Bell Ability Scale was assigned, and a blood sample was taken for the "ATP profile" test, designed for CFS and other fatigue conditions. Each test produced 5 numerical factors which describe the availability of ATP in neutrophils, the fraction complexed with magnesium, the efficiency of oxidative phosphorylation, and the transfer efficiencies of ADP into the mitochondria and ATP into the cytosol where the energy is used. With the consent of each of 71 patients and 53 normal, healthy controls the 5 factors have been collated and compared with the Bell Ability Scale. The individual numerical factors show that patients have different combinations of biochemical lesions. When the factors are combined, a remarkable correlation is observed between the degree of mitochondrial dysfunction and the severity of illness (P<0.001). Only 1 of the 71 patients overlaps the normal region. The "ATP profile" test is a powerful diagnostic tool and can differentiate patients who have fatigue and other symptoms as a result of energy wastage by stress and psychological factors from those who have insufficient energy due to cellular respiration dysfunction. The individual factors indicate which remedial actions, in the form of dietary supplements, drugs and detoxification, are most likely to be of benefit, and what further tests should be carried out.

PMID: 19436827 [PubMed - in process]

Shampoos.

Dermatitis. 2009 Mar-Apr;20(2):106-10.

Shampoos.

Ohio State University, Columbus, USA.

Shampoos are used almost universally in developed countries to wash the hair on a daily basis. A number of known contact allergens are used as ingredients in shampoos, and contact allergy due to shampoos is a well known entity. Patch testing can be used to identify ingredients to which patients are allergic, after which the physician can help the patient to find a shampoo that is free of the ingredients to which they are allergic. The ingredients used in shampoos have not been systematically reviewed in recent years in the United States. We use a database of products sold at a major drug store to quantify the most frequent allergens used in shampoos. The allergens most commonly present, in order of prevalence are as follows: fragrance, cocamidopropyl betaine, methylchloroisothiazolinone/methylisothiazolinone, formaldehyde releasers, propylene glycol, vitamin E, parabens, benzophenones, iodopropynyl butylcarbamate, and methyldibromoglutaronitrile/phenoxyethanol.

PMID: 19426617 [PubMed - in process]

Examining antecedents of clean indoor air policy support: implications for campaigns promoting clean indoor air.

Health Commun. 2009 Jan;24(1):50-9.LinkOut

Examining antecedents of clean indoor air policy support: implications for campaigns promoting clean indoor air.

Department of Communication, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. bquick@illinois.edu

This investigation sought to examine the association between knowledge of the risks associated with environmental tobacco smoke and voter support for clean indoor air policies. In doing so, 2 antecedents were employed to enhance understanding of this relationship: attitudes and subjective norms. In addition, differences between nonsmokers and smokers were assessed across the aforementioned variables. The study sampled participants (N = 550) living in the Appalachian foothills as a means of conducting formative research prior to developing messages promoting clean indoor air policies. The study controlled for tobacco usage, age, biological sex, and income. Results revealed that awareness of risk is a good predictor of attitudes and social norms, and in return, attitudes and social norms are good predictors of support for clean indoor air policies. In addition, results reveal that nonsmokers maintain a significantly stronger belief in the dangers associated with environmental tobacco smoke, as well as more favorable attitudes, subjective norms, and support for clean indoor air policies when compared with smokers. These findings are discussed with a focus on message design strategies for practitioners and academics with interests in promoting clean indoor air policies.

PMID: 19204858 [PubMed - indexed for MEDLINE]

Friday, May 15, 2009

Special May Awareness Month News/Links Edition, May 15, 2009

Special May Awareness Month News/Links Edition, May 15, 2009

In the United States alone, it is estimated that more than over 48 million men, women, and children suffer adverse health reactions to everyday chemicals. 

Multiple chemical sensitivity and toxic injury is an increasing epidemic which leads to emergency department visits, job loss, homelessness, school absenteeism, and serious lifelong chronic illness in America. Multiple chemical sensitivity (MCS) affects men, women, and children irregardless of gender, race and economic status.

In response to these alarming statistics, and in an effort to raise public awareness of the risks faced everyday by Americans living with multiple chemical sensitivity and toxic injury, May is Multiple Chemical Sensitivity and Toxic Injury Awareness Month in America.

Thirty-six governors and mayors across America have issued proclamations for this important event.

Events are being held across the United States during May. Each event will raise awareness about indoor and outdoor pollutants that trigger multiple chemical sensitivity and toxic injury, as well as ways to prevent toxic injuries and exposures.
 
Below is a sampling of the vast efforts of various individuals and organizations around the country to expand awareness.  Congratulations to each individual and organization who has gone out of their way to making this the best May awareness event ever! 
 
May is only half over.  If each and every one of us does something, even if it's only one little thing, it makes your voice heard.  More important, it makes our collective voices heard. 
 
Wishing everyone improved health and progress,
 
Lourdes

=================================

Allergy and Environmental Sensitivity Support and Research Association, Inc.
Chemical Sensitivity 2009 Seminar (Australia) May 15, 2009
http://www.mcs-america.org/AESSRAChemicalSensitivty09Seminar.pdf
Medical, legal and architectural experts discuss chemical sensitivity and its impacts on the lives of sufferers and family.

Press Release
http://www.mcs-america.org/ChemicalSensitivitySeminar2009PressRelease.pdf

Flyer
http://www.mcs-america.org/AESSRAChemicalSensitivty09Seminar.pdf

Are You Sensitive to Chemicals?
http://www.mcs-america.org/areyousensitivetochemicals.pdf

=================================

International MCS/EMS Awareness 2009 Library Display
http://www.nettally.com/prusty/Formww.htm
Observance of MCS/EMS Awareness Month May 2009 in Florida, USA

=================================
Library Seminar
Eating Green with Jeff Heinen
http://www.cuyahogalibrary.org/EventDetail.aspx?EventInstanceID=32707

Branch: Parma Heights - Meeting Room A
Type of Event: Program
Date: Wednesday, May 13, 2009 7:00 PM

Jeff Heinen, co-owner of Heinen's Fine Foods presents...
Eating Green: learn about the growing popularity of organically and locally grown food. Mr. Heinen shares his insights about this current trend as well as food safety.

Presented in collaboration with the Ohio Network for the Chemically Injured.

=================================

Library Seminar
The Environment and Your Health
http://www.cuyahogalibrary.org/EventDetail.aspx?EventInstanceID=32705

Branch: Parma Heights - Meeting Room A
Type of Event: Program
Date: Wednesday, May 06, 2009 7:00 PM

Theodore Esborn, environmental attorney, ONFCI* Board Member and co-executive producer of the PBS documentary, Return of the Cuyahoga,
presents...
 
The Environment and Your Health: the hidden dangers in your surroundings and their consequences.

Whether from natural and man-made disasters or everyday chemicals, we are exposed to an increasingly diverse array of harmful pollutants and toxins that can create adverse reactions in our bodies.

Learn the connection between chemicals and cancer, asthma, MCS, Parkinson's and other disabilities.

*Presented in collaboration with the Ohio Network for the Chemically Injured.

=================================
 
MCS, Toxic Injury, and EMS Proclamations
Copies of governor and mayor proclamations obtained by various organizations and individuals across America.
 
=================================

Ohio Senators Dale Miller (D-Cleveland) and Kevin Coughlin (R-Cuyahoga Falls) introduced Senate Bill No. 117 today to annually designate May as MCS Awareness Month in Ohio

Letter from the ONFCI requesting support:
http://www.ohionetwork.org/2009/letter_re_bill.pdf

Actual Senate Bill:
http://www.legislature.state.oh.us/BillText128/128_SB_117_I_Y.pdf

=================================

MCS America's May Activism Kit
Chock full of ideas, both big and small, on how to promote MCS/TI Awareness
 
=================================

National Fibromyalgia Awareness Day - May 12, 2009
http://www.baxterbulletin.com/article/20090502/NEIGHBORHOODS01/905020343

=================================

Comment:  This is a great brochure to email or distribute to emergency medical personnel to increase awareness of MCS and encourage proper treatment in medical emergencies.  It's produced by the University of New Mexico Center for Development and Disability.

Now Available - Third Edition of Tips for First Responders!
http://cdd.unm.edu/products/TipSheetsForFirstResponders.htm

Tips for First Responders, a 14-page, color-coded, laminated 4.5 x 5.5-inch field guide. For the third edition a tip sheet has been added that offers
information to first responders on how to assist Childbearing Women and Newborns. Tips also include persons with a wide range of disabilities, as
well as Seniors, People with Service Animals, People with Mobility Challenges, People with Mental Illness, Blind or Visually Impaired People,
Deaf or Hard of Hearing People, People with Autism, People with Multiple Chemical Sensitivities and People with Cognitive Disabilities.

The tip sheets provide information first responders can use during emergencies as well as routine encounters. They are not meant to be
comprehensive, but contain specific information that you can read quickly either before or while responding to an incident. Over 80,000 copies of the tips have been ordered by first responders across the country.

Partners in developing the Tip Sheets include the Bureau of Health Emergency Management, New Mexico Department of Health; the New Mexico Governor's Commission on Disability; the American Association on Health and Disability; and the Disability and Health Branch of the Centers for Disease Control and Prevention

View PDF Version of the Tips for First Responders
http://cdd.unm.edu/products/tips3rdedition.pdf
You must have Adobe Acrobat Reader to View this file

Download the Tips for First Responders order form in Adobe Acrobat Reader
http://cdd.unm.edu/products/TIPSheetOrderForm.pdf
You can print this form and fax or mail it to us.

Contact us for further information
mailto:acahill@salud.unm.edu
Or call Dr. Anthony Cahill at 505-272-2990

=================================

Winning entries of the UK M.E. Awareness Week Poster Competition
"Come to bed with ME" and "If you catch ME" designed by Joss Morton
http://www.mefreeforall.org/fileadmin/PDFs/ME_Awareness_Posters_2009.pdf

=================================

May is MCS Awareness Month Poster
http://www.ohionetwork.org/2009/flowchart.pdf

New Meaning for Dead on Arrival Poster
http://www.ohionetwork.org/2009/postersmall.jpg

The DOA poster has been giving folks trouble.  The link is right, but for some reason it can't be directly accessed.  It can be accessed from:
http://www.ohionetwork.org/ by clicking on "Greening" of the Fleets" in the left menu and then clicking "View Dead on Arrival Poster" in the main screen.

=================================

Thirty-six governors and 30 mayors issued Environmental Education Week proclamations stressing the value of and need for environmental education in their states and cities.

Children's Environmental Health Network: Environmental Education Week
http://www.eeweek.org/

=================================

Connecticut Governor proclaims May 2009 as Electromagnetic Sensitivity (EMS)
Awareness Month.

http://www.americanchronicle.com/articles/view/102308

The proclamation was obtained by the hard work of CHRISTIANE TOURTET B.A.
Founder/President of International MCS/EMS Awareness
http://www.nettally.com/prusty/mcs.htm

The direct link to the EMS proclamation is as follows:
http://www.nettally.com/prusty/JREMS2009.pdf

=================================
Radio Interview
Trends and Products: our worsening indoor air
http://www.abc.net.au/rn/bydesign/stories/2009/2562183.htm

Chemically sensitive? How safe is your house? The average person spends approximately 60% of their time in the indoor environment. As we move to conserve energy in our houses we often need to close off the house -- but this means less air flow and more potential for a poor quality of indoor air.

Guests
Neil Blyth
Architect

Further Information
Chemical Sensitivity 2009 website
AESSRA is the Allergy and Environmental Sensitivity Support and Research
Association Inc

Producer
Janne Ryan

Radio National often provides links to external websites to complement program information. While producers have taken care with all selections, we can neither endorse nor take final responsibility for the content of those sites.
 
=================================

Arizona Trail hiker spotlights fibromyalgia
http://www.tucsoncitizen.com/altss/printstory/frontpage/115981

=================================

PRESS RELEASE

MCS America Celebrates Multiple Chemical Sensitivity and Toxic Injury  Awareness Month
http://www.americanchronicle.com/articles/view/100998

In the United States alone, it is estimated that more than over 48 million men, women, and children suffer adverse health reactions to everyday chemicals.

Multiple chemical sensitivity and toxic injury is an increasing epidemic which leads to emergency department visits, job loss, homelessness, school absenteeism, and serious lifelong chronic illness in America. Multiple chemical sensitivity (MCS) affects over 48 million men, women, and children irregardless of gender, race and economic status.

In response to these alarming statistics, and in an effort to raise public awareness of the risks faced everyday by Americans living with multiple chemical sensitivity and toxic injury in May is Multiple Chemical Sensitivity and Toxic Injury Awareness Month in America.

Twenty-five governors and mayors across America have issued proclamations for this important event.

Events are being held across the United States during May. Each event will raise awareness about indoor and outdoor pollutants that trigger multiple chemical sensitivity and toxic injury, as well as ways to prevent toxic injuries and exposures.

MCS is a Major Public Health Concern

At least 45 million people in the US report sensitivity to various chemicals.[1]

About 3 million Americans are diagnosed with MCS.[1]

MCS affects people of all ages, economic status, race, and both genders.[1]

Chemicals that people with MCS react to are toxic and affect everyone to some extent.

Medical Findings

Brain scans show reduced blood flow to the brain when people with MCS are under chemical exposure.[2-7]

Physical variances identified in MCS include brain inflammation, oxidative stress, excitotoxicity, cardiac and airway disease, and auto-immune disorders.[8-14]

Mast cell activation and disorders of porphyrin metabolism have been linked to MCS.[15]

Genetic variations relating to detoxification processes have been linked to MCS.[16]

The Cost of Environmental Illnesses

Annual expenditures for healthcare and lost productivity due to MCS are estimated at $71.8 billion dollars per year.[18]

Environmental Factors

Indoor and outdoor environmental exposures can trigger reactions: perfumes and fragrances, cleaning solutions, scented laundry products, pesticides, herbicides, paint and building materials, gasoline and petroleum based products, artificial flavors, colors, and preservatives.[12]

MCS Can be Controlled

MCS can be controlled with a plan that includes avoidance and control of environmental triggers, many people with MCS can lead normal, healthy, and active lives.[18]

For more information on MCS America´s awareness program, visit
www.mcs-america.org.

References

Kreutzer R, Neutra RR, & Lashuay N. Prevalence of people reporting sensitivities to chemicals in a population-based survey. Am J Epidemiol. 1999 Jul 1;150(1):1-12.

Heuser G, Mena I. Neurospect in neurotoxic chemical exposure demonstration of long-term functional abnormalities. Toxicol Ind Health. 1998;Nov-Dec;14(6):813-27.

Callender, TJ, et al. Three-dimensional brain and metabolic imaging in patients with toxic encephalopathy. Environmental Res. 1993;60: 295-319.

Callender, TJ, et al. Evaluation of chronic neurological sequelae after acute pesticide exposure using SPECT brain scans. Journal Toxicology & Environmental Health. 1995;41:275-284.

Heuser, G, et al. Neurospect findings in patients exposed to neurotoxic chemicals. Toxicology & Industrial Health. 1994;10:561-571.

Ross GH, Rea WJ, Johnson AR, Hickey DC, and Simon TR: Neurotoxicity in single photon emission computed tomography brain scans of patients reporting chemical sensitivities. Toxicol Ind Health 1999;15(3-4):415-420.

Simon TR, Hickey DC, Fincher CE, Johnson AR, Ross GH and Rea WJ: Single Photon Emission Computed Tomography of the brain in patients with chemical sensitivities. Toxicol Ind Health 1994;10:573-577.

Elofsson, S, et. a. Exposure to organic solvents. Scandinavian Journal of Work & Environmental Health. 1980;6:239-273.

Seppalainen, AM, et al. Neurophysiological effects of long-term exposure to a mixture of organic solvents. Scandinavian Journal of Work & Environmental Health. 1978;4:304-314.

Jonkman, EJ, et al. Electroencephalographic studies in workers exposed to solvents or pesticides. Electro Clinical Neurophysiology. 1992;82:439-444.

Bokina, AI, et al. Investigation of the mechanism of action of atmospheric pollutants on the central nervous system and comparative evaluation of methods of study. Environmental Health Perspectives. 1976;13:37-42.

Ziem, G. and McTamney, J. Profile of patients with chemical injury and sensitivity. Environ Health Perspect 1997;105:417-436.

Bell I.R. Baldwin, C.M. and Schwartz, G.E. Illness from low levels of environmental chemicals: relevance to chronic fatigue syndrome and fibromyalgia. Am J Med. 1998;105:74S-82S.

Baldwin, CM and Bell, IR. Increased cardiopulmonary disease risk in a community-based sample with chemical odor intolerance: implications for women's health and health- care utilization. Arch Environ Health 1998;53:347-353.

Heuser, G. and Kent, P. 1996. Mast cell disorder after chemical exposure. 124th Annual Meeting of the American Public Health Association, New York NY, 20 November 1996.

Zeim, G, McTamney, J. Profile of patients with chemical injury and sensitivity. Environ Health Perspect. 1997 March; 105(Suppl 2): 417–436.

Fox RA, Joffres MR, Sampalli T, Casey J. The impact of a multidisciplinary, holistic approach to management of patients diagnosed with multiple chemical sensitivity on health care utilization costs: an observational study. J Altern Complement Med. 2007 Mar;13(2):223-9.

Gibson, P. Perceived treatment efficacy for conventional and alternative therapies reported by persons with multiple chemical sensitivity. Environmental Health Perspectives. 2003;111:12,1498–1504.
 
=================================
(Permission to Forward)
 

MAY ACTIVISM: Trends and Products: our worsening indoor air

Trends and Products: our worsening indoor air

Chemically sensitive? How safe is your house? The average person spends approximately 60% of their time in the indoor environment. As we move to conserve energy in our houses we often need to close off the house -- but this means less air flow and more potential for a poor quality of indoor air.

Neil Blyth
Architect

Further Information

Chemical Sensitivity 2009 website
AESSRA is the Allergy and Environmental Sensitivity Support and Research Association Inc

Producer

Janne Ryan

Radio National often provides links to external websites to complement program information. While producers have taken care with all selections, we can neither endorse nor take final responsibility for the content of those sites.

MAY ACTIVISM: Connecticut Governor proclaims May 2009 as Electromagnetic Sensitivity (EMS) Awareness Month

Connecticut Governor proclaims May 2009 as Electromagnetic Sensitivity (EMS) Awareness Month.
 
The proclamation was obtained by the hard work of CHRISTIANE TOURTET B.A. Founder/President of International MCS/EMS Awareness
 
The direct link to the EMS proclamation is as follows:
 
Please circulate the annoncement worldwide.
 
Thank you,
 
Christiane Tourtet B.A.
Founder/President
International MCS/EMS Awareness
 
Due to the extraordinary amount of e-mails anticipated,
it will not be possible for Christiane Tourtet to be able to answer to everyone.Thank you.

MAY ACTIVISM: EE Week

Thirty-six governors and 30 mayors issued Environmental Education Week
proclamations stressing the value of and need for environmental education in
their states and cities.

Children's Environmental Health Network: Environmental Education Week
http://www.eeweek.org/

MAY ACTIVISM: MCS Posters from ONFCI

May is MCS Awareness Month Poster
 
New Meaning for Dead on Arrival Poster

The DOA poster has been giving folks trouble.  The link is right, but for some reason it can't be directly accessed.  It can be accessed from:  http://www.ohionetwork.org/ by clicking on "Greening" of the Fleets" in the left menu and then clicking "View Dead on Arrival Poster" in the main screen. 
 

MAY ACTIVISM: Winning entries of the UK M.E. Awareness Week

Winning entries of the UK M.E. Awareness Week Poster Competition
"Come to bed with ME" and "If you catch ME" designed by Joss Morton
http://www.mefreeforall.org/fileadmin/PDFs/ME_Awareness_Posters_2009.pdf
._,___

MAY ACTIVISM: Montana Governor Recognizes May 2009 As Multiple Chemical Sensitivity ( MCS) /EI Awareness Month

Montana Governor Recognizes May 2009 As Multiple Chemical Sensitivity ( MCS) /EI Awareness Month

http://www.americanchronicle.com/articles/view/101082

Christiane Tourtet B.A.

May 02, 2009

Governor Brian Schweitzer stated that he was pleased to recognize

"Multiple Chemical Sensitivity (MCS)/ Environmental Injury (EI)

Awareness Month in Montana", and that preventing exposures to harmful chemicals is critical in protecting public health and safety.

The Governor also stated that "reduction of hazardous chemicals in our environment can help eliminate "MCS and EI ".

He applauded Vanessa Gaudette, in her efforts to educate the public about "MCS/EI " and raise awareness of prevention and solutions.


The Governor encouraged all Montanans to take time to learn about the illness and he recognized May 2009 as

"(MCS/EI ) Month ".

For more information on MCS/EI, please visit :

MCS Homepage

http://www.nettally.com/prusty/mcs.htm

mcs-america.org

http://www.mcs-america.org/

© 2009 Christiane Tourtet . All rights reserved.

MAY ACTIVISM: Now Available - Third Edition of Tips for First Responders!

Comment:  This is a great brochure to email or distribute to emergency medical personnel to increase awareness of MCS and encourage proper treatment in medical emergencies.  It's produced by the University of New Mexico Center for Development and Disability.
 

Now Available - Third Edition of Tips for First Responders!

 

Tips for First RespondersTips for First Responders, a 14-page, color-coded, laminated 4.5 x 5.5-inch field guide. For the third editon a tip sheet has been added that offers information to first responders on how to assist Childbearing Women and Newborns. Tips also include persons with a wide range of disabilities, as well as Seniors, People with Service Animals, People with Mobility Challenges, People with Mental Illness, Blind or Visually Impaired People, Deaf or Hard of Hearing People, People with Autism, People with Multiple Chemical Sensitivities and People with Cognitive Disabilities.

 

The tip sheets provide information first responders can use during emergencies as well as routine encounters. They are not meant to be comprehensive, but contain specific information that you can read quickly either before or while responding to an incident. Over 80,000 copies of the tips have been ordered by first reponders across the country.

 

Partners in developing the Tip Sheets include the Bureau of Health Emergency Management, New Mexico Department of Health; the New Mexico Governor's Commission on Disability; the American Association on Health and Disability; and the Disability and Health Branch of the Centers for Disease Control and Prevention

 

View PDF Version of the Tips for First Responders >>> http://cdd.unm.edu/products/tips3rdedition.pdf
You must have Adobe Acrobat Reader to View this file

 

Download the Tips for First Responders order form in Adobe Acrobat Reader >>>

http://cdd.unm.edu/products/TIPSheetOrderForm.pdf
You can print this form and fax or mail it to us.

 

Contact us for further information >>> mailto:acahill@salud.unm.edu

Or call Dr. Anthony Cahill at 505-272-2990

RETURN TO PRODUCTS MAIN PAGE >>>

MAY ACTIVISM: National Fibromyalgia Awareness Day - May 12, 2009National Fibromyalgia Awareness Day - May 12, 2009

National Fibromyalgia Awareness Day - May 12, 2009
http://www.baxterbulletin.com/article/20090502/NEIGHBORHOODS01/905020343

CITY, STATE- On May 12, 2009, residents of Mountain Home will join millions
of people worldwide to observe Fibromyalgia Awareness Day. Led by the
National Fibromyalgia Association, the theme for this year's campaign is
"Fibromyalgia Affects Everyone" and focuses on the far-reaching effects of
this common, chronic pain disorder-from broken lives to the economic costs
for patients and society.

An estimated 10 million men, women and children in the United States suffer
from fibromyalgia, which is characterized by chronic widespread pain,
multiple tender points, abnormal pain processing, sleep disturbances, and
fatigue.

For those with severe symptoms, fibromyalgia can be extremely debilitating
and interfere with basic daily activities.

Total healthcare costs over 12 months are about three times higher among
fibromyalgia patients compared to patients without the disorder

Fibromyalgia costs the U.S. between $12-$14 billion each year

"Fibromyalgia Awareness Day provides an opportunity to educate others in our
local community about this life-altering disorder-and to bring hope to the
millions of people who suffer from it," says (Lakeview resident Linda
Brisbois).

ABOUT AWARENESS DAY

In 1993, Tom Hennessy, the founder of RESCIND, INC. (Repeal Existing
Stereotypes about Chronic Immunological and Neurological Diseases),
designated May 12 as International Awareness Day for Chronic Immunological
and Neurological Diseases (CIND). The date was chosen to memorialize the
birth date of Florence Nightingale, the English army nurse who inspired the
founding of the International Red Cross. Nightingale contracted a
paralyzing, CIND-like illness in her mid-30s and spent the last 50 years of
her life virtually bedridden. Despite her illness, she managed to found the
first-ever School of Nursing. Awareness Day activities take place worldwide
in an effort to increase awareness of chronic pain illnesses including
fibromyalgia.

ABOUT THE NATIONAL FIBROMYALGIA ASSOCIATION:

The National Fibromyalgia Association is a nonprofit organization whose
mission is to develop and execute programs dedicated to improving the
quality of life for people with fibromyalgia. The NFA publishes a quarterly
magazine, Fibromyalgia AWARE, and hosts an award-winning website at
www.fmaware.org.

MAY ACTIVISM: MCS Senate Bill in Ohio No. 117

Ohio Senators Dale Miller (D-Cleveland) and Kevin Coughlin (R-Cuyahoga
Falls) introduced Senate Bill No. 117 today to annually designate May as MCS
Awareness Month in Ohio

Letter from the ONFCI requesting support:
http://www.ohionetwork.org/2009/letter_re_bill.pdf

Actual Sentate Bill:
http://www.legislature.state.oh.us/BillText128/128_SB_117_I_Y.pdf

MAY ACTIVISM: MCS America Celebrates Multiple Chemical Sensitivity and Toxic Injury Awareness Month

PRESS RELEASE

MCS America Celebrates Multiple Chemical Sensitivity and Toxic Injury Awareness Month
http://www.prlog.org/10228421-mcs-america-celebrates-multiple-chemical-sensitivity-and-toxic-injury-awareness-month.html

In response to alarming statistics, and to raise public awareness of the risks faced everyday by Americans, May is Multiple Chemical Sensitivity and Toxic Injury Awareness Month in America.
 

MAY ACTIVISM: Library Meeting: The Environment and Your Health

The Environment and Your Health

Branch: Parma Heights - Meeting Room A

Type of Event: Program

Date: Wednesday, May 06, 2009 7:00 PM

Theodore Esborn, environmental attorney, ONFCI* Board Member and co-executive producer of the PBS documentary, Return of the Cuyahoga, presents...

The Environment and Your Health: the hidden dangers in your surroundings and thier consequences.

Whether from natural and man-made disasters or everyday chemicals, we are exposed to an increasingly diverse array of harmful pollutants and toxins that can create adverse reactions in our bodies.

Learn the connection between chemicals and cancer, asthma, MCS, Parkinson's and other disabilities.

*Presented in collaboration with the Ohio Network for the Chemically Injured.

MAY ACTIVISM: Library Meeting: Eating Green with Jeff Heinen

Eating Green with Jeff Heinen

Branch: Parma Heights - Meeting Room A

Type of Event: Program

Date: Wednesday, May 13, 2009 7:00 PM

Jeff Heinen, co-owner of Heinen's Fine Foods presents...

Eating Green: learn about the growing popularity of organically and locally grown food. Mr. Heinen shares his insights about this current trend as well as food safety.

Presented in collaboration with the Ohio Network for the Chemically Injured.

Register
 

MAY ACTIVISM: International MCS/EMS Awareness 2009 Library Display

International MCS/EMS Awareness 2009 Library Display
http://www.nettally.com/prusty/Formww.htm
Observance of MCS/EMS Awareness Month May 2009 in Florida, USA
 

MAY ACTIVISM: Chemical Sensitivity 2009 Seminar (Australia)

Allergy and Environmental Sensitivity Support and Research Association, Inc.
Chemical Sensitivity 2009 Seminar (Australia) May 15, 2009

http://www.mcs-america.org/ChemicalSensitivitySeminar2009PressRelease.pdf

Medical, legal and architectural experts discuss chemical sensitivity and its impacts on the lives of sufferers and family.  

Press Release     
Flyer   

MAY ACTIVISM: Australia MCS Seminar and Brochure

Allergy and Environmental Sensitivity Support and Research Association, Inc.
Chemical Sensitivity '09 Seminar (Australia)
http://www.mcs-america.org/AESSRAChemicalSensitivty09Seminar.pdf
 
Are You Sensitive to Chemicals? 
 
Chemical Sensitivity 2009 Seminar (Australia) May 15, 2009
http://www.mcs-america.org/ChemicalSensitivitySeminar2009PressRelease.pdf
Medical, legal and architectural experts discuss chemical sensitivity and its impacts on the lives of sufferers and family.
 

MAY ACTIVISM: Arizona Trail hiker spotlights fibromyalgia

Arizona Trail hiker spotlights fibromyalgia

 
Tucsonan due to complete last leg of 800-mile walk
 
Published: 05.07.2009
 
When she set out to hike the 800-mile Arizona Trail last spring, Sirena Dufault worried that she might not finish.
The daunting trail stretches from Utah to the U.S.-Mexico border.
 
Tucsonan Dufault's concern stemmed from her decade-long battle with fibromyalgia, a little-understood chronic pain disorder.
 
"I was a little hesitant to publicize it because I didn't know how far I could go," Dufault said this week. "Now I can comfortably do a 15-mile day with a big pack, no problem."
 
<snip>

COLORADO Governor proclaims May 2009 as Electromagnetic Sensitivity (EMS) Awareness Month.

COLORADO Governor proclaims May 2009 as Electromagnetic Sensitivity (EMS) Awareness Month.
http://www.americanchronicle.com/articles/view/102568

The proclamation was obtained due to the dedication and extremely hard work of Christiane Tourtet, B.A. Founder/President of International MCS/EMS Awareness
http://www.nettally.com/prusty/mcs.htm

The direct link to the EMS proclamation is as follows:
http://www.nettally.com/prusty/COEMS2009.pdf

Please circulate this annoncement worldwide.

Thank you,

Christiane Tourtet B.A.
Founder/President
International MCS/EMS Awareness
http://www.nettally.com/prusty/mcs.htm

Due to the extraordinary amount of e-mails anticipated,
it will not be possible for Christiane Tourtet to be able to answer to everyone. Thank you.

Monday, May 11, 2009

Semivolatile Organic Compounds in Residential Air along the Arizona−Mexico Border

Environ. Sci. Technol., 2009, 43 (9), pp 3054–3060

Semivolatile Organic Compounds in Residential Air along the Arizona−Mexico Border
http://pubs.acs.org/doi/abs/10.1021/es803482u

Robert W. Gale* , Walter L. Cranor , David A. Alvarez , James N. Huckins , Jimmie D. Petty  and Gary L. Robertson‡

Columbia Environmental Research Center, United States Geological Survey, 4200 New Haven Road, Columbia, Missouri 65201, and Office of Research and Development, National Exposure Research Laboratory, Human Exposure and Atmospheric Sciences Division, United States Environmental Protection Agency, 944 East Harmon Avenue, Las Vegas, Nevada 89119

Environ. Sci. Technol., 2009, 43 (9), pp 3054–3060
DOI: 10.1021/es803482u
Publication Date (Web): March 26, 2009

Copyright This article not subject to U.S. Copyright. Published 2009 by the American Chemical Society

* Corresponding author phone: (573)441-2971; fax: (573)876-1896; e-mail: rgale@usgs.gov.,   United States Geological Survey.
, ‡ United States Environmental Protection Agency.

Abstract
Concerns about indoor air quality and the potential effects on people living in these environments are increasing as more reports about the toxicities and the potential indoor air exposure levels of household-use chemicals and chemicals from housing and furnishing manufacture in air are being assessed. Gas chromatography/mass spectrometry was used to confirm numerous airborne contaminants obtained from the analysis of semipermeable membrane devices deployed inside of 52 homes situated along the border between Arizona and Mexico. We also describe nontarget analytes in the organochlorine pesticide fractions of 12 of these homes; this fraction is also the most likely to contain the broadest scope of bioconcentratable chemicals accumulated from the indoor air. Approximately 400 individual components were identified, ranging from pesticides to a wide array of hydrocarbons, fragrances such as the musk xylenes, flavors relating to spices, aldehydes, alcohols, esters and phthalate esters, and other miscellaneous types of chemicals. The results presented in this study demonstrate unequivocally that the mixture of airborne chemicals present indoors is far more complex than previously demonstrated.

Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure.

Hum Reprod. 2002 Nov;17(11):2839-41.

Determination of bisphenol A concentrations in human biological fluids reveals significant early prenatal exposure.
http://www.ncbi.nlm.nih.gov/sites/entrez/12407035

Ikezuki Y, Tsutsumi O, Takai Y, Kamei Y, Taketani Y.

BACKGROUND: There is broad human exposure to bisphenol A (BPA), an estrogenic endocrine-disrupting chemical widely used for the production of plastic products. BPA is reported to affect preimplantation embryos or fetuses and alter their postnatal development at doses typically found in the environment. We measured contamination of BPA in various kinds of human biological fluids by a novel enzyme-linked immunosorbent assay. METHODS: Blood samples were obtained from healthy premenopausal women, women with early and full-term pregnancy, and umbilical cord at full-term delivery. Ovarian follicular fluids obtained during IVF procedures and amniotic fluids obtained at mid-term and full-term pregnancy were also subject to BPA measurements. RESULTS: BPA was present in serum and follicular fluid at approximately 1-2 ng/ml, as well as in fetal serum and full-term amniotic fluid, confirming passage through the placenta. Surprisingly, an approximately 5-fold higher concentration, 8.3 +/- 8.7 ng/ml, was revealed in amniotic fluid at 15-18 weeks gestation, compared with other fluids. CONCLUSION: These results suggest accumulation of BPA in early fetuses and significant exposure during the prenatal period, which must be considered in evaluating the potential for human exposure to endocrine-disrupting chemicals.

Sunday, May 10, 2009

Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain.

Pain. 2009 Apr 30. [Epub ahead of print]Click here to read LinkOut

Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain.

Stockholm Brain Institute, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden.

Over the years, many have viewed Fibromyalgia syndrome (FMS) as a so-called "functional disorder" and patients have experienced a concomitant lack of interest and legitimacy from the medical profession. The symptoms have not been explained by peripheral mechanisms alone nor by specific central nervous system mechanisms. In this study, we objectively evaluated the cerebral response to individually calibrated pain provocations of a pain-free body region (thumbnail). The study comprised 16 female FMS patients and 16 individually age-matched controls. Brain activity was measured using functional magnetic resonance imaging (fMRI) during individually calibrated painful pressures representing 50mm on a visual analogue scale (VAS) ranging from 0 to 100mm. Patients exhibited higher sensitivity to pain provocation than controls as they required less pressure to evoke equal pain magnitudes (U(A)=48, p<.002). Despite lower pressures applied in patients at VAS 50mm, the fMRI-analysis revealed no difference in activity in brain regions relating to attention and affect or regions with sensory projections from the stimulated body area. However, in the primary link in the descending pain regulating system (the rostral anterior cingulate cortex) the patients failed to respond to pain provocation. The attenuated response to pain in this brain region is the first demonstration of a specific brain region where the impairment of pain inhibition in FMS patients is expressed. These results validate previous reports of dysfunctional endogenous pain inhibition in FMS and advance the understanding of the central pathophysiologic mechanisms, providing a new direction for the development of successful treatments in FMS.

PMID: 19410366 [PubMed - as supplied by publisher]

Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder.

J Pain. 2009 May;10(5):542-52.

Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder.

Health Sciences Center, University of Utah, Salt Lake City, Utah, USA. Kathleen.C.Light@hsc.utah.edu

In patients with fibromyalgia syndrome (FMS) and temporomandibular disorder (TMD), stress and pain may chronically enhance sympathetic activity, altering cardiovascular responses and worsening pain. This study examined cardiovascular, epinephrine (EPI), norepinephrine (NE), cortisol and clinical pain responses in 54 female patients with these disorders and 34 controls. In a subsample of 10 FMS, 10 TMD patients and 16 controls, using a counterbalanced, double-blind, crossover design, the same responses were assessed after intravenous administration of low dose propranolol vs placebo. Testing included baseline, postural, speech and ischemic pain stressors. FMS patients showed lesser heart rate (HR) increases to posture challenge but greater blood pressure (BP) increases to postural and speech tasks than controls, as well as higher overall BP and greater total vascular resistance (TVR) than TMDs or controls. TMDs showed higher overall cardiac output and lower TVR than controls. Both FMS and TMD groups showed lower baseline NE than controls, and TMDs showed lower overall EPI and NE levels. Group differences in HR, EPI and NE were abolished after propranolol although BP, CO and TVR differences persisted. In both FMS and TMD, the number of painful body sites and ratings of total clinical pain obtained 4 times during each session were significantly lower after beta-blockade vs placebo. PERSPECTIVE: These findings support the hypothesis that both FMS and TMD may frequently involve dysregulation of beta-adrenergic activity that contributes to altered cardiovascular and catecholamine responses and to severity of clinical pain. Acute treatment with low-dose propranolol led to short-term improvement in all these domains.

PMID: 19411061 [PubMed - in process]

Decreased Gray Matter Volumes in the Cingulo-Frontal Cortex and the Amygdala in Patients With Fibromyalgia.

Psychosom Med. 2009 May 4. [Epub ahead of print]

Decreased Gray Matter Volumes in the Cingulo-Frontal Cortex and the Amygdala in Patients With Fibromyalgia.

Department of Psychosomatics and Psychotherapy (M.B., M.W., S.H., G.H.), the Department of Medicine B (M.G.), Interdisciplinary Centre for Clinical Research Münster (IZKF), and Department of Psychiatry and Psychotherapy (C.K.), and the Department of Clinical Radiology (B.P.), University Hospital Münster, Münster, Germany.

Objective: Studies in fibromyalgia syndrome with functional neuroimaging support the hypothesis of central pain augmentation. To determine whether structural changes in areas of the pain system are additional preconditions for the central sensitization in fibromyalgia we performed voxel based morphometry in patients with fibromyalgia and healthy controls. Methods: We performed 3 Tesla magnetic resonance imaging of the brain in 14 patients with fibromyalgia and 14 healthy controls. Regional differences of the segmented and normalized gray matter volumes in brain areas of the pain system between both groups were determined. In those areas in which patients structurally differed from healthy controls, the correlation of disease-related factors with gray matter volumes was analyzed. Results: Patients presented a decrease in gray matter volume in the prefrontal cortex, the amygdala, and the anterior cingulate cortex (ACC). The duration of pain or functional pain disability did not correlate with gray matter volumes. A trend of inverse correlation of gray matter volume reduction in the ACC with the duration of pain medication intake has been detected. Conclusions: Our results suggest that structural changes in the pain system are associated with fibromyalgia. As disease factors do not correlate with reduced gray matter volume in areas of the cingulo-frontal cortex and the amygdala in patients, one possible interpretation is that volume reductions might be a precondition for central sensitization in fibromyalgia.

PMID: 19414621 [PubMed - as supplied by publisher]

Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure.

Toxicology. 2009 May 4. [Epub ahead of print]Click here to read

Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure.

Laboratory for Health Protection Research, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands.

There are currently no validated animal models that can identify low molecular weight (LMW) respiratory sensitizers. The Local Lymph Node Assay (LLNA) is a validated animal model developed to detect contact sensitizers using skin exposure, but all LMW respiratory sensitizers tested so far were also positive in this assay. Discrimination between contact and respiratory sensitizers can be achieved by the assessment of cytokine profiles. In a LLNA using the inhalation route, both contact and respiratory sensitizers enhanced proliferation in the draining lymph nodes. The question was if their cytokine profiles were affected by the route of exposure. Male BALB/c mice were exposed head/nose-only during three consecutive days to the respiratory sensitizers trimellitic anhydride, phthalic anhydride, toluene diisocyanate, hexamethylene diisocyanate (HDI), and isophorone diisocyanate; the contact sensitizers dinitrochlorobenzene (DNCB), oxazolone (OXA) and formaldehyde (FA), and the irritant methyl salicylate (MS). Three days after the last exposure the draining lymph nodes were excised and cytokine production was measured after ex vivo stimulation with Concavalin A. Skin application was used as a positive control. After inhalation exposure the respiratory sensitizers induced more interleukin-4 (IL-4) and interleukin (IL-10) compared to the contact sensitizers, whereas the contact sensitizers, except formaldehyde, induced relatively more interferon-gamma (IFN- gamma) production. When IL-4 and IFN-gamma were plotted as a function of the proliferative response, it was shown that IL-4 could be used to identify respiratory sensitizers, except HDI, at concentration levels inducing intermediate stimulation indices. HDI could be distinguished from DNCB and OXA at high SI values. In contrast, contact sensitizers could only be identified when IFN-gamma was measured at high stimulation indices. The skin positive control, tested at high concentrations, showed comparable results for IL-4 and IL-10, whereas IFN-gamma levels could not be used to discriminate between respiratory and contact sensitizers. The contact sensitizer FA and the irritant MS did not induce significant cytokine production after inhalation and skin exposure. In conclusion, the respiratory LLNA is able to identify and distinguish strong contact and respiratory sensitizers when simultaneously proliferation and cytokine production are assessed in the upper respiratory tract draining LNs.

PMID: 19422874 [PubMed - as supplied by publisher]

Saturday, May 9, 2009

Incident Diabetes and Pesticide Exposure among Licensed Pesticide Applicators: Agricultural Health Study, 1993-2003

American Journal of Epidemiology Advance Access originally published online on March 14, 2008
American Journal of Epidemiology 2008 167(10):1235-1246; doi:10.1093/aje/kwn028

 

Incident Diabetes and Pesticide Exposure among Licensed Pesticide Applicators: Agricultural Health Study, 1993–2003

M. P. Montgomery1, F. Kamel1, T. M. Saldana2, M. C. R. Alavanja3 and D. P. Sandler1

1 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC
2 Social & Scientific Systems, Durham, NC
3 Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD

Correspondence to Dr. Dale P. Sandler, Epidemiology Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709 (e-mail: sandler@niehs.nih.gov ).

Received for publication October 2, 2007. Accepted for publication January 25, 2008.

Exposure to certain environmental toxicants may be associated with increased risk of developing diabetes. The authors' aim was to investigate the relation between lifetime exposure to specific agricultural pesticides and diabetes incidence among pesticide applicators. The study included 33,457 licensed applicators, predominantly non-Hispanic White males, enrolled in the Agricultural Health Study. Incident diabetes was self-reported in a 5-year follow-up interview (1999–2003), giving 1,176 diabetics and 30,611 nondiabetics for analysis. Lifetime exposure to pesticides and covariate information were reported by participants at enrollment (1993–1997). Using logistic regression, the authors considered two primary measures of pesticide exposure: ever use and cumulative lifetime days of use. They found seven specific pesticides (aldrin, chlordane, heptachlor, dichlorvos, trichlorfon, alachlor, and cyanazine) for which the odds of diabetes incidence increased with both ever use and cumulative days of use. Applicators who had used the organochlorine insecticides aldrin, chlordane, and heptachlor more than 100 lifetime days had 51%, 63%, and 94% increased odds of diabetes, respectively. The observed association of organochlorine and organophosphate insecticides with diabetes is consistent with results from previous human and animal studies. Long-term exposure from handling certain pesticides, in particular, organochlorine and organophosphate insecticides, may be associated with increased risk of diabetes.

agrochemicals; diabetes mellitus; environmental exposure; hydrocarbons, chlorinated; insecticides; pesticides; phosphoric acid esters

Friday, May 8, 2009

Exposure to organic solvents and cytogenetic damage in exfoliated cells of the buccal mucosa from shoe workers.

Int Arch Occup Environ Health. 2009 Feb;82(3):373-80. Epub 2008 Jul 3.Click here to read LinkOut
Comment in:
Int Arch Occup Environ Health. 2009 Mar;82(4):547-8; author reply 549.

Exposure to organic solvents and cytogenetic damage in exfoliated cells of the buccal mucosa from shoe workers.

Instituto de Investigaciones sobre el Trabajo, Universidad de Guanajuato, Leon, Guanajuato, Mexico.

PURPOSE: We determined the solvents mainly used in shoe making and their genotoxic effects. METHODS: Thirty-four exposed shoe workers and 34 unexposed control subjects, paired by age and sex, were compared. Occupational exposure was determined by using monitors 3M. Solvents were assessed by gas chromatography. Exfoliated buccal cells were obtained from each subject to determine the incidence of micronuclei and other nuclear abnormalities. One thousand cells were counted in each subject. RESULTS: Solvents detected were acetone, ethyl acetate, methyl ethyl ketone, and toluene. The incidence of nuclear abnormalities was significatively higher in the exposed group when compared to the control group. A positive relationship between the incidence of micronuclei and the toluene concentration in the environment was found. CONCLUSIONS: Toluene shows an important genotoxic effect. As the micronuclei test is an effective, fast, simple and low cost biomarker to identify cytogenetic effects, we suggest its utilization as a preventive test of genotoxicity.

PMID: 18597106 [PubMed - indexed for MEDLINE]

Calculation of the indoor gamma dose rate distribution due to building materials in the Netherlands.

Radiat Prot Dosimetry. 2008;132(4):381-9. Epub 2008 Dec 30.Click here to read LinkOut

Calculation of the indoor gamma dose rate distribution due to building materials in the Netherlands.

Nuclear Research and consultancy Group (NRG), PO Box 9034, 6800 ES Arnhem, The Netherlands. p.dejong@nrg.eu

In this study, a model to determine the indoor absorbed dose rate in air due to building materials is applied to a representative set of 1336 Dutch dwellings of which the areas occupied by the various kinds of building material are well documented. Using a Monte Carlo method, the building material and housing data are combined with activity concentrations and densities of 90 samples of building material. From (100,000) repeated calculations according to the model, the distribution of the absorbed dose rate in Dutch livings is computed. The outcomes are compared with those of earlier national measuring campaigns on the indoor dose rate. When corrected for cosmic and terrestrial radiation, a similar distribution of the indoor dose rate is found with an average value within 5% of that found by measurements. A sensitivity analysis revealed that the three most influential input parameters of the model are the density and thickness of the construction parts, the presence of doors and windows and attenuation by the inner cavity wall.

PMID: 19117957 [PubMed - indexed for MEDLINE]

Combining regional- and local-scale air quality models with exposure models for use in environmental health studies.

J Air Waste Manag Assoc. 2009 Apr;59(4):461-72.

Combining regional- and local-scale air quality models with exposure models for use in environmental health studies.

Office of Research and Development, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. lsakov.Vlad@epa.gov

Population-based human exposure models predict the distribution of personal exposures to pollutants of outdoor origin using a variety of inputs, including air pollution concentrations; human activity patterns, such as the amount of time spent outdoors versus indoors, commuting, walking, and indoors at home; microenvironmental infiltration rates; and pollutant removal rates in indoor environments. Typically, exposure models rely upon ambient air concentration inputs from a sparse network of monitoring stations. Here we present a unique methodology for combining multiple types of air quality models (the Community Multi-Scale Air Quality [CMAQ] chemical transport model added to the AERMOD dispersion model) and linking the resulting hourly concentrations to population exposure models (the Hazardous Air Pollutant Exposure Model [HAPEM] or the Stochastic Human Exposure and Dose Simulation [SHEDS] model) to enhance estimates of air pollution exposures that vary temporally (annual and seasonal) and spatially (at census-block-group resolution) in an urban area. The results indicate that there is a strong spatial gradient in the predicted mean exposure concentrations near roadways and industrial facilities that can vary by almost a factor of 2 across the urban area studied. At the high end of the exposure distribution (95th percentile), exposures are higher in the central district than in the suburbs. This is mostly due to the importance of personal mobility factors whereby individuals living in the central area often move between microenvironments with high concentrations, as opposed to individuals residing at the outskirts of the city. Also, our results indicate 20-30% differences due to commuting patterns and almost a factor of 2 difference because of near-roadway effects. These differences are smaller for the median exposures, indicating the highly variable nature of the reflected ambient concentrations. In conjunction with local data on emission sources, microenvironmental factors, and behavioral and socioeconomic characteristics, the combined source-to-exposure modeling methodology presented in this paper can improve the assessment of exposures in future community air pollution health studies.

PMID: 19418820 [PubMed - in process]

Wednesday, May 6, 2009

Detection of herpesviruses and parvovirus b19 in gastric and intestinal mucosa of chronic fatigue syndrome patients.

Detection of herpesviruses and parvovirus b19 in gastric and intestinal mucosa of chronic fatigue syndrome patients.
   
Journal: In Vivo. 2009 Mar-Apr;23(2):209-13.

Authors: Frémont M, Metzger K, Rady H, Hulstaert J, DE Meirleir K.

Affiliation: Protea Biopharma, Z.1-Researchpark 100, 1731 Zellik, Belgium. <mfremont@proteabiopharma.com>.

NLM Citation: PMID: 19414405
  

BACKGROUND: Human herpesvirus-6 (HHV-6), Epstein-Barr virus and parvovirus B19 have been suggested as etiological agents of chronic fatigue syndrome but none of these viruses is consistently detected in all patients. However, active viral infections may be localized in specific tissues, and, therefore, are not easily detectable. The aim of this study was to investigate the presence of HHV-6, HHV-7, EBV and parvovirus B19 in the gastro-intestinal tract of CFS patients.

PATIENTS AND METHODS: Using real-time PCR, viral DNA loads were quantified in gastro-intestinal biopsies of 48 CFS patients and 35 controls.

RESULTS: High loads of HHV-7 DNA were detected in most CFS and control biopsies. EBV and HHV-6 were detected in 15-30% of all biopsies. Parvovirus B19 DNA was detected in 40% of the patients versus less than 15% of the controls.

CONCLUSION: Parvovirus B19 may be involved in the pathogenesis of CFS, at least for a subset of patients. The gastro-intestinal tract appears as an important reservoir of infection for several potentially pathogenic viruses.

Merck Paid Elsevier to Publish Phony Peer-Review Journal

Merck Paid Elsevier to Publish Phony Peer-Review Journal
 
     
Tuesday, 05 May 2009
 
Merck is reported to have created a fake "peer-reviewed" journal to present favorable data that made its potentially fatal drugs--Fosamax and Vioxx--look good.  Documents uncovered during the Australian class action lawsuit involving 1,000 consumers, against Merck & Co and its Australian subsidiary, Merck Sharpe and Dohme, are shocking even to hardened critics of pharmaceutical industry corrupt practices. Reports are swirling about Merck's underhanded marketing scheme evidently cooked up to mislead doctors into prescribing its potentially fatal drugs--Fosamax (for osteoporosis) and Vioxx (for pain). [1] [2]
 
See link above for full story.

Morbidity Experience in Populations Residentially Exposed to 50 Hz Magnetic Fields

Morbidity Experience in Populations Residentially Exposed to 50 Hz Magnetic Fields

 
Lucia Fazzo, Valeria Tancioni, Alessandro Polichetti, Ivano Iavarone, Nicola Vanacore, Paolo Papini, Sara Farchi, Caterina Bruno, Roberto Pasetto, Piero Borgia, Pietro Comba

Abstract

A morbidity study of the population of a district of Rome built in part under a 60 kV electric distribution line, included 345 subjects resident in the study area in any period between 1954 and 2003, excluding those deceased before 1998. Residential magnetic field levels were estimated based on current load, line characteristics, and distance of the dwellings from the power line, and the study area was divided into sub-areas with differing magnetic field levels. Standardized morbidity ratios were computed from hospital discharge records dated 1998–2003. Non statistically significant increases were observed for all and primary cancers; primary cancers were significantly increased among subjects with >30 years' residence and latency. A significant increase for all, primary, and secondary cancers, and a two-fold increase for ischaemic diseases, was observed in subjects in the sub-area with the highest exposure. No increase was seen in neoplastic haematological diseases.

Sunday, May 3, 2009

Flame retardants in indoor dust and air of a hotel in Japan.

Environ Int. 2009 May;35(4):688-93. Epub 2009 Jan 30.Click here to read Compound (MeSH Keyword), Substance (MeSH Keyword), LinkOut

Flame retardants in indoor dust and air of a hotel in Japan.

Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies, Tsukuba 305-8506, Japan. takigami@nies.go.jp

Occurrence of flame retardants (FRs) in the indoor environment of highly flame-retarded public facilities is an important concern from the viewpoint of exposure because it is likely that FRs are used to a greater degree in these facilities than in homes. For this study, brominated flame-retardants (BFRs) and organophosphate flame-retardants and plasticizers (OPs), and brominated dibenzo-p-dioxins/furans (PBDD/DFs) were measured in eight floor dust samples taken from a Japanese commercial hotel that was assumed to have many flame-retardant materials. Concentrations of polybrominated diphenylethers (PBDEs) and hexabromocyclododecanes (HBCDs) varied by about two orders of magnitude, from 9.8-1700 ng/g (median of 1200 ng/g) and from 72-1300 ng/g (median of 740 ng/g), respectively. Concentrations of the two types of BFRs described above were most dominant among the investigated BFRs in the dust samples. It is inferred that BFR and PBDD/DF concentrations are on the same level as those in house and office dust samples reported based on past studies. Regarding concentrations of 11 OPs, 7 OPs were detected on the order of micrograms per gram, which are equivalent to or exceed the BFR concentrations such as PBDEs and HBCDs. Concentrations of the investigated compounds were not uniform among dust samples collected throughout the hotel: concentrations differed among floors, suggesting that localization of source products is associated with FR concentrations in dust. Passive air sampling was also conducted to monitor BFRs in the indoor air of hotel rooms: the performance of an air cleaner placed in the room was evaluated in terms of reducing airborne BFR concentrations. Monitoring results suggest that operation of an appropriate air cleaner can reduce both gaseous and particulate BFRs in indoor air.

PMID: 19185920 [PubMed - indexed for MEDLINE]

Existence state of bromine as an indicator of the source of brominated flame retardants in indoor dust.

Environ Sci Technol. 2009 Mar 1;43(5):1437-42.

Existence state of bromine as an indicator of the source of brominated flame retardants in indoor dust.

Research Center for Material Cycles and Waste Management, National Institute for Environmental Studies, Tsukuba, 305-8506, Japan. gosu0911@agr.ehime-u.ac.jp

Indoor dust is an important medium for human exposure to brominated flame retardants (BFRs) such as polybrominated diphenyl ethers (PBDEs). In this study, we used micro X-ray fluorescence spectrometry (XRFS), digital optical microscopy, and gas chromatography-high resolution mass spectrometry to investigate the existence state of bromine as an indicator of the source of BFRs in indoor dusts and in dusts from the interior of televisions collected in Japan. By means of micro XRFS bromine mapping conducted at a 0.5-s dwell time, we were able to detect bromine levels as low as about 0.1% at each point of about a beam diameter of 50 microm across. The presence of fragments containing 1.0% or more bromine was confirmed in 27 of the 48 dust samples tested. Using magnified images of the fragments, we classified them roughly into particulates and fibrous substances. We analyzed PBDEs in the fragments containing high concentrations of bromine (> or = 0.1%) and confirmed that the fragments contained PBDEs, mainly BDE 209. Furthermore, to detect bromine concentrations < or = 0.1% in the dust samples, we analyzed the samples at a dwell time of 100 s to enhance the detection sensitivity of mapping; atthis dwell time, we confirmed the presence of bromine in the dust coating. Our results suggest that bromine is transferred from products to dust matrixes not only through miniaturization and subsequent direct migration into dust as plastic and textile fragments but also through other pathways such as vaporization and airborne transfer of microparticulates.

PMID: 19350916 [PubMed - indexed for MEDLINE]

Association of Early-life Exposure to Household Gas Appliances and Indoor Nitrogen Dioxide With Cognition and Attention Behavior in Preschoolers.

Am J Epidemiol. 2009 Apr 24. [Epub ahead of print]Click here to read LinkOut

Association of Early-life Exposure to Household Gas Appliances and Indoor Nitrogen Dioxide With Cognition and Attention Behavior in Preschoolers.

The authors investigated the association of early-life exposure to indoor air pollution with neuropsychological development in preschoolers and assessed whether this association differs by glutathione-S-transferase gene (GSTP1) polymorphisms. A prospective, population-based birth cohort was set up in Menorca, Spain, in 1997-1999 (n = 482). Children were assessed for cognitive functioning (McCarthy Scales of Children's Abilities) and attention-hyperactivity behaviors (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition) at age 4 years. During the first 3 months of life, information about gas appliances at home and indoor nitrogen dioxide concentration was collected at each participant's home (n = 398, 83%). Genotyping was conducted for the GSTP1 coding variant Ile105Val. Use of gas appliances was inversely associated with cognitive outcomes (beta coefficient for general cognition = -5.10, 95% confidence interval (CI): -9.92, -0.28; odds ratio for inattention symptoms = 3.59, 95% CI: 1.14, 11.33), independent of social class and other confounders. Nitrogen dioxide concentrations were associated with cognitive function (a decrease of 0.27 point per 1 ppb, 95% CI: -0.48, -0.07) and inattention symptoms (odds ratio = 1.06, 95% CI: 1.01, 1.12). The deleterious effect of indoor pollution from gas appliances on neuropsychological outcomes was stronger in children with the GSTP1 Val-105 allele. Early-life exposure to air pollution from indoor gas appliances may be negatively associated with neuropsychological development through the first 4 years of life, particularly among genetically susceptible children.

PMID: 19395695 [PubMed - as supplied by publisher]

Functional Neuroimaging of Fatigue.

Phys Med Rehabil Clin N Am. 2009 May;20(2):325-337. LinkOut

Functional Neuroimaging of Fatigue.

Kessler Foundation Research Center, 1199 Pleasant Valley Way, West Orange, NJ 07052, USA; Department of Physical Medicine and Rehabilitation, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, USA; Department of Neurology and Neuroscience, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, NJ, USA.

Recent studies employing functional neuroimaging provide new insights into the elusive construct of fatigue. Studies have been conducted primarily in persons with multiple sclerosis (MS) and chronic fatigue syndrome (CFS). These studies outline the key role of the basal ganglia and frontal lobes in understanding the neural mechanisms associated with fatigue. The lack of a relationship between self-reported fatigue and objectively measured fatigue is outlined, and new functional imaging paradigms may lead to significant advances in relating cognitive fatigue to functional cerebral activity.

PMID: 19389614 [PubMed - as supplied by publisher]

Saturday, May 2, 2009

Air Pollution Exposures and Circulating Biomarkers of Effect in a Susceptible

Air Pollution Exposures and Circulating Biomarkers of Effect in a
Susceptible
Population: Clues to Potential Causal Component Mixtures and Mechanisms
http://www.ehponline.org/docs/2009/0800194/abstract.pdf

Ralph J. Delfino,1 Norbert Staimer,1 Thomas Tjoa,1 Daniel L. Gillen,2 Andrea
Polidori,3
Mohammad Arhami,3 Micheal T. Kleinman,4 Nosratola D. Vaziri,5 John
Longhurst,5
Constantinos Sioutas.3

ABSTRACT

Background: Mechanisms involving oxidative stress and inflammation have been
proposed
to explain associations of ambient air pollution with cardiovascular
morbidity and mortality.
Experimental evidence suggests organic components and ultrafine particles
are important.

Methods: We conducted a panel study of 60 elderly subjects with coronary
artery disease
living in retirement communities within the Los Angeles air basin. Weekly
biomarkers of
inflammation included plasma interleukin-6 (IL-6), tumor necrosis factor-?
and receptor
(sTNF-RII), soluble platelet selectin (sP-selectin), and C-reactive protein
(CRP).
Biomarkers of erythrocyte antioxidant activity included glutathione
peroxidase-1 and
superoxide dismutase. Exposures included outdoor home daily particle mass
(PM0.25,
PM0.25-2.5, PM2.5-10), and hourly elemental and black carbon (EC-BC),
estimated primary and
secondary organic carbon (OCpri, SOC), particle number (PN), CO, and
NOx-NO2. We
analyzed the relation of biomarkers to exposures with mixed effects models
adjusted for
potential confounders.

Results: Primary combustion markers (EC-BC, OCpri, CO, NOx-NO2), but not
SOC, were
positively associated with inflammatory biomarkers and inversely associated
with
erythrocyte antioxidant enzymes (N=578). PN and PM0.25 were more strongly
associated
with biomarkers than PM0.25-2.5. Associations for all exposures were
stronger during cooler
periods when only OCpri, PN, and NOx were higher. We found weaker
associations with
statin (sTNF-RII, CRP) and clopidogrel use (sP-selectin).

Conclusions: Traffic-related air pollutants are associated with increased
systemic
inflammation, increased platelet activation, and decreased erythrocyte
antioxidant enzyme
activity, which may be partly behind air pollutant-related increases in
systemic inflammation.
Differences in association by particle size, OC fraction, and seasonal
period suggest
components carried by ultrafine particles are important.

Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California.

Am J Epidemiol. 2009 Apr 15;169(8):919-26. Epub 2009 Mar 6.

Click here to read
Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California.

Costello S, Cockburn M, Bronstein J, Zhang X, Ritz B.

Department of Environmental Health Sciences, University of California, Berkeley, 94720-7360, USA. sadie@berkeley.edu

Evidence from animal and cell models suggests that pesticides cause a neurodegenerative process leading to Parkinson's disease (PD). Human data are insufficient to support this claim for any specific pesticide, largely because of challenges in exposure assessment. The authors developed and validated an exposure assessment tool based on geographic information systems that integrated information from California Pesticide Use Reports and land-use maps to estimate historical exposure to agricultural pesticides in the residential environment. In 1998-2007, the authors enrolled 368 incident PD cases and 341 population controls from the Central Valley of California in a case-control study. They generated estimates for maneb and paraquat exposures incurred between 1974 and 1999. Exposure to both pesticides within 500 m of the home increased PD risk by 75% (95% confidence interval (CI): 1.13, 2.73). Persons aged < or =60 years at the time of diagnosis were at much higher risk when exposed to either maneb or paraquat alone (odds ratio = 2.27, 95% CI: 0.91, 5.70) or to both pesticides in combination (odds ratio = 4.17, 95% CI: 1.15, 15.16) in 1974-1989. This study provides evidence that exposure to a combination of maneb and paraquat increases PD risk, particularly in younger subjects and/or when exposure occurs at younger ages.

PMID: 19270050

NEWS: Tests of women leaders show how toxins turn up in Americans' blood

Tests of women leaders show how toxins turn up in Americans' blood
http://www.greenrightnow.com/kabc/2009/05/01/tests-of-five-women-environmental-leaders-show-how-toxic-chemicals-turn-up-in-americans-blood/2/

"I'll have to stop using perfume, which is something I really enjoy, but finding out these really high levels in my body is really disturbing," she said. "… you think you're doing something that's hygienic and clean."

Friday, May 1, 2009

NEWS: Household Chemicals May Show Up in Blood

Comment: This appeared on WebMD.
 
Household Chemicals May Show Up in Blood
http://www.webmd.com/news/20090501/household-chemicals-may-show-up-in-blood

Study by Environmental Group Shows Toxic Chemicals End Up in Blood Samples

May 1, 2009 -- Up to 48 toxic chemicals commonly used in everyday consumer products have shown up in blood and urine samples of five prominent women environmental activists, according to a study by the Environmental Working Group, a nonprofit organization devoted to protecting human health and the environment.

"Testing was primarily targeted toward products used in everyday consumer products that have escaped regulation under the Toxic Substances Control Act," Anila Jacob, MD, MPH, a senior scientist with the organization, said at a news briefing.
 

Household Chemicals May Show Up in Blood

Household Chemicals May Show Up in Blood
http://www.webmd.com/news/20090501/household-chemicals-may-show-up-in-blood

Study by Environmental Group Shows Toxic Chemicals End Up in Blood Samples

May 1, 2009 -- Up to 48 toxic chemicals commonly used in everyday consumer products have shown up in blood and urine samples of five prominent women environmental activists, according to a study by the Environmental Working Group, a nonprofit organization devoted to protecting human health and the environment.

"Testing was primarily targeted toward products used in everyday consumer products that have escaped regulation under the Toxic Substances Control Act," Anila Jacob, MD, MPH, a senior scientist with the organization, said at a news briefing.
 

Duloxetine in fibromyalgia: rejection. Marketing authorization rejected and rightly so.

Prescrire Int. 2009 Feb;18(99):14.LinkOut

Duloxetine in fibromyalgia: rejection. Marketing authorization rejected and rightly so.

[No authors listed]

The European marketing authorization committee has ruled against the utilisation of duloxetine (Cymbalta) in the treatment of diffuse idiopathic polyalgic syndrome, alias fibromyalgia. A coherent position, given this psychotropic drug's unfavourable risk-benefit balance.

PMID: 19388210 [PubMed - indexed for MEDLINE]

A new nonpharmacological method in fibromyalgia: the use of wool.

J Altern Complement Med. 2009 Apr;15(4):399-405.Click here to read LinkOut

A new nonpharmacological method in fibromyalgia: the use of wool.

Atatürk University, School of Nursing, Erzurum, Turkey. frtemine@hotmail.com

OBJECTIVES: The aim was to assess the effect of wool use in patients with fibromyalgia. BACKGROUND: Various studies concerning the treatment of patients with fibromyalgia using nonpharmacological methods have been carried out. There are, however, no reports on the use of wool clothing and bedding in treating these patients. DESIGN AND METHODS: The study employed two-group, experimental design. A total of 50 patients with fibromyalgia, based on the criteria of the American College of Rheumatology, were selected for the study. They were distributed equally into two groups: a control group and a treatment group. The 25 patients in each group were randomly selected and the compositions of the two groups were statistically identical. The patients in the treatment group wore woolen underwear (which covered the body from the shoulders to the thighs) and used woolen bedding such as woolen bed liner, woolen quilt and pillow during the experimental period of 6 weeks. All patients were assessed at the beginning the trial (pre-test) and the end of 6th (post-test) week. Data were collected using the visual analogue scale (0-10), tender points count, and Fibromyalgia Impact Questionnaire. RESULTS: Patients in the treatment group reported significant improvements in their conditions including a reduction in pain levels, tender point counts, and all scores of the Fibromyalgia Impact Questionnaire (p <or= 0.001). CONCLUSIONS: The use of woolen underwear and woolen bedding were effective in reducing the symptoms of patients suffering from fibromyalgia. The use of wool is recommended as a means of treatment for alleviating the pain of fibromyalgia. RELEVANCE TO CLINICAL PRACTICE: Nurses provide professional support to patients with fibromyalgia. They select suitable clothes and sleeping materials for their patients with this object in mind: to keep their patients warm and to protect them from the cold.

PMID: 19388862 [PubMed - in process]

Changes in Gray Matter Density in Fibromyalgia: Correlation With Dopamine Metabolism.

J Pain. 2009 Apr 22. [Epub ahead of print]

Changes in Gray Matter Density in Fibromyalgia: Correlation With Dopamine Metabolism.

Department of Family Medicine, Anesthesiology, and Psychiatry, Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana.

Fibromyalgia (FM) has been associated with alterations in brain morphometry and abnormal dopaminergic neurotransmission. Evidence from preclinical models has demonstrated that dopamine plays a role in promoting neuronal integrity. We therefore sought to confirm previous findings of reduced gray matter density in subjects with FM and to determine whether variations in dopamine metabolism might affect gray matter density. Voxel-based morphometry was used to evaluate anatomical magnetic resonance imaging data from 30 female FM subjects in comparison with 20 age- and gender-matched healthy control subjects. In addition, data from a subset of subjects from both groups who had previously participated in our positron emission tomography study using radiolabeled DOPA (n = 14; 6 FM subjects and 8 control subjects) was used to determine whether correlation might exist between gray matter density and dopamine metabolism. We found a significant reduction in gray matter density within the bilateral parahippocampal gyri, right posterior cingulate cortex, and left anterior cingulate cortex. In addition, a positive correlation was demonstrated between an index of dopamine metabolism from the ventral tegmental area wherein cell bodies of corticolimbic projection neurons originate and gray matter density, specifically in the bilateral parahippocampal gyri and left pregenual cortex. The current results confirm our previous findings that FM is associated with altered brain morphometry. Alterations in dopamine metabolism might contribute to the associated changes in gray matter density. PERSPECTIVE: Fibromyalgia is associated with reductions in gray matter density within brain regions ostensibly involved in phenomena related to the disorder, including enhanced pain perception, cognitive dysfunction, and abnormal stress reactivity. Given mounting evidence of abnormal dopaminergic neurotransmission associated with the disorder, the strong correlation between dopamine metabolism and gray matter density provides insight as to the pathophysiology that might contribute to these changes.

PMID: 19398377 [PubMed - as supplied by publisher]

NEWS: MCS America Celebrates Multiple Chemical Sensitivity and Toxic Injury Awareness Month

MCS America Celebrates Multiple Chemical Sensitivity and Toxic Injury Awareness Month

 

In response to alarming statistics, and to raise public awareness of the risks faced everyday by Americans, May is Multiple Chemical Sensitivity Awareness Month.


For_Immediate_Release:
 
In the United States alone, it is estimated that more than over 48 million men, women, and children suffer adverse health reactions to everyday chemicals.

Multiple chemical sensitivity and toxic injury is an increasing epidemic which leads to emergency department visits, job loss, homelessness, school absenteeism, and serious lifelong chronic illness in America. Multiple chemical sensitivity (MCS) affects over 48 million men, women, and children irregardless of gender, race and economic status.

In response to these alarming statistics, and in an effort to raise public awareness of the risks faced everyday by Americans living with multiple chemical sensitivity and toxic injury in May is Multiple Chemical Sensitivity and Toxic Injury Awareness Month in America.

Twenty-five governors and mayors across America have issued proclamations for this important event.

Events are being held across the United States during May. Each event will raise awareness about indoor and outdoor pollutants that trigger multiple chemical sensitivity and toxic injury, as well as ways to prevent toxic injuries and exposures.

MCS is a Major Public Health Concern

At least 45 million people in the US report sensitivity to various chemicals.[1]
About 3 million Americans are diagnosed with MCS.[1]
MCS affects people of all ages, economic status, race, and both genders.[1]
Chemicals that people with MCS react to are toxic and affect everyone to some extent.

Medical Findings

Brain scans show reduced blood flow to the brain when people with MCS are under chemical exposure.[2-7]
Physical variances identified in MCS include brain inflammation, oxidative stress, excitotoxicity, cardiac and airway disease, and auto-immune disorders.[8-14]
Mast cell activation and disorders of porphyrin metabolism have been linked to MCS.[15]
Genetic variations relating to detoxification processes have been linked to MCS.[16]

The Cost of Environmental Illnesses

Annual expenditures for healthcare and lost productivity due to MCS are estimated at $71.8 billion dollars per year.[18]

Environmental Factors

Indoor and outdoor environmental exposures can trigger reactions: perfumes and fragrances, cleaning solutions, scented laundry products, pesticides, herbicides, paint and building materials, gasoline and petroleum based products, artificial flavors, colors, and preservatives.[12]

MCS Can be Controlled

MCS can be controlled with a plan that includes avoidance and control of environmental triggers, many people with MCS can lead normal, healthy, and active lives.[18]

For more information on MCS America's awareness program, visit www.mcs-america.org.

References

Kreutzer R, Neutra RR, & Lashuay N. Prevalence of people reporting sensitivities to chemicals in a population-based survey. Am J Epidemiol. 1999 Jul 1;150(1):1-12.

Heuser G, Mena I. Neurospect in neurotoxic chemical exposure demonstration of long-term functional abnormalities. Toxicol Ind Health. 1998;Nov-Dec;14(6):813-27.

Callender, TJ, et al. Three-dimensional brain and metabolic imaging in patients with toxic encephalopathy. Environmental Res. 1993;60: 295-319.

Callender, TJ, et al. Evaluation of chronic neurological sequelae after acute pesticide exposure using SPECT brain scans. Journal Toxicology & Environmental Health. 1995;41:275-284.

Heuser, G, et al. Neurospect findings in patients exposed to neurotoxic chemicals. Toxicology & Industrial Health. 1994;10:561-571.

Ross GH, Rea WJ, Johnson AR, Hickey DC, and Simon TR: Neurotoxicity in single photon emission computed tomography brain scans of patients reporting chemical sensitivities. Toxicol Ind Health 1999;15(3-4):415-420.

Simon TR, Hickey DC, Fincher CE, Johnson AR, Ross GH and Rea WJ: Single Photon Emission Computed Tomography of the brain in patients with chemical sensitivities. Toxicol Ind Health 1994;10:573-577.

Elofsson, S, et. a. Exposure to organic solvents. Scandinavian Journal of Work & Environmental Health. 1980;6:239-273.

Seppalainen, AM, et al. Neurophysiological effects of long-term exposure to a mixture of organic solvents. Scandinavian Journal of Work & Environmental Health. 1978;4:304-314.

Jonkman, EJ, et al. Electroencephalographic studies in workers exposed to solvents or pesticides. Electro Clinical Neurophysiology. 1992;82:439-444.

Bokina, AI, et al. Investigation of the mechanism of action of atmospheric pollutants on the central nervous system and comparative evaluation of methods of study. Environmental Health Perspectives. 1976;13:37-42.

Ziem, G. and McTamney, J. Profile of patients with chemical injury and sensitivity. Environ Health Perspect 1997;105:417-436.

Bell I.R. Baldwin, C.M. and Schwartz, G.E. Illness from low levels of environmental chemicals: relevance to chronic fatigue syndrome and fibromyalgia. Am J Med. 1998;105:74S-82S.

Baldwin, CM and Bell, IR. Increased cardiopulmonary disease risk in a community-based sample with chemical odor intolerance: implications for women's health and health- care utilization. Arch Environ Health 1998;53:347-353.

Heuser, G. and Kent, P. 1996. Mast cell disorder after chemical exposure. 124th Annual Meeting of the American Public Health Association, New York NY, 20 November 1996.

Zeim, G, McTamney, J. Profile of patients with chemical injury and sensitivity. Environ Health Perspect. 1997 March; 105(Suppl 2): 417–436.

Fox RA, Joffres MR, Sampalli T, Casey J. The impact of a multidisciplinary, holistic approach to management of patients diagnosed with multiple chemical sensitivity on health care utilization costs: an observational study. J Altern Complement Med. 2007 Mar;13(2):223-9.

Gibson, P. Perceived treatment efficacy for conventional and alternative therapies reported by persons with multiple chemical sensitivity. Environmental Health Perspectives. 2003;111:12,1498–1504.

Key Words: multiple chemical sensitivity, chemical sensitivity, chemical sensitivities, multiple chemical sensitivities, MCS, EI, environmental illness, sick building syndrome, idiopathic environmental intolerance, fibromyalgia, chronic fatiuge, FM, CFS, mold illness, clinical ecology, alternative medicine, environmental medicine, neuropathy, encephalopathy, toxic, chemical

MCS America Celebrates Multiple Chemical Sensitivity and Toxic Injury Awareness Month

In the United States alone, it is estimated that more than over 48 million men, women, and children suffer adverse health reactions to everyday chemicals.

Multiple chemical sensitivity and toxic injury is an increasing epidemic which leads to emergency department visits, job loss, homelessness, school absenteeism, and serious lifelong chronic illness in America. Multiple chemical sensitivity (MCS) affects over 48 million men, women, and children irregardless of gender, race and economic status.

In response to these alarming statistics, and in an effort to raise public awareness of the risks faced everyday by Americans living with multiple chemical sensitivity and toxic injury in May is Multiple Chemical Sensitivity and Toxic Injury Awareness Month in America.

Twenty-five governors and mayors across America have issued proclamations for this important event.

Events are being held across the United States during May. Each event will raise awareness about indoor and outdoor pollutants that trigger multiple chemical sensitivity and toxic injury, as well as ways to prevent toxic injuries and exposures.

MCS is a Major Public Health Concern

At least 45 million people in the US report sensitivity to various chemicals.[1]
About 3 million Americans are diagnosed with MCS.[1]
MCS affects people of all ages, economic status, race, and both genders.[1]
Chemicals that people with MCS react to are toxic and affect everyone to some extent.

Medical Findings

Brain scans show reduced blood flow to the brain when people with MCS are under chemical exposure.[2-7]
Physical variances identified in MCS include brain inflammation, oxidative stress, excitotoxicity, cardiac and airway disease, and auto-immune disorders.[8-14]
Mast cell activation and disorders of porphyrin metabolism have been linked to MCS.[15]
Genetic variations relating to detoxification processes have been linked to MCS.[16]

The Cost of Environmental Illnesses

Annual expenditures for healthcare and lost productivity due to MCS are estimated at $71.8 billion dollars per year.[18]

Environmental Factors

Indoor and outdoor environmental exposures can trigger reactions: perfumes and fragrances, cleaning solutions, scented laundry products, pesticides, herbicides, paint and building materials, gasoline and petroleum based products, artificial flavors, colors, and preservatives.[12]

MCS Can be Controlled

MCS can be controlled with a plan that includes avoidance and control of environmental triggers, many people with MCS can lead normal, healthy, and active lives.[18]

For more information on MCS America’s awareness program, visit www.mcs-america.org.

References

Kreutzer R, Neutra RR, & Lashuay N. Prevalence of people reporting sensitivities to chemicals in a population-based survey. Am J Epidemiol. 1999 Jul 1;150(1):1-12.

Heuser G, Mena I. Neurospect in neurotoxic chemical exposure demonstration of long-term functional abnormalities. Toxicol Ind Health. 1998;Nov-Dec;14(6):813-27.

Callender, TJ, et al. Three-dimensional brain and metabolic imaging in patients with toxic encephalopathy. Environmental Res. 1993;60: 295-319.

Callender, TJ, et al. Evaluation of chronic neurological sequelae after acute pesticide exposure using SPECT brain scans. Journal Toxicology & Environmental Health. 1995;41:275-284.

Heuser, G, et al. Neurospect findings in patients exposed to neurotoxic chemicals. Toxicology & Industrial Health. 1994;10:561-571.

Ross GH, Rea WJ, Johnson AR, Hickey DC, and Simon TR: Neurotoxicity in single photon emission computed tomography brain scans of patients reporting chemical sensitivities. Toxicol Ind Health 1999;15(3-4):415-420.

Simon TR, Hickey DC, Fincher CE, Johnson AR, Ross GH and Rea WJ: Single Photon Emission Computed Tomography of the brain in patients with chemical sensitivities. Toxicol Ind Health 1994;10:573-577.

Elofsson, S, et. a. Exposure to organic solvents. Scandinavian Journal of Work & Environmental Health. 1980;6:239-273.

Seppalainen, AM, et al. Neurophysiological effects of long-term exposure to a mixture of organic solvents. Scandinavian Journal of Work & Environmental Health. 1978;4:304-314.

Jonkman, EJ, et al. Electroencephalographic studies in workers exposed to solvents or pesticides. Electro Clinical Neurophysiology. 1992;82:439-444.

Bokina, AI, et al. Investigation of the mechanism of action of atmospheric pollutants on the central nervous system and comparative evaluation of methods of study. Environmental Health Perspectives. 1976;13:37-42.

Ziem, G. and McTamney, J. Profile of patients with chemical injury and sensitivity. Environ Health Perspect 1997;105:417-436.

Bell I.R. Baldwin, C.M. and Schwartz, G.E. Illness from low levels of environmental chemicals: relevance to chronic fatigue syndrome and fibromyalgia. Am J Med. 1998;105:74S-82S.

Baldwin, CM and Bell, IR. Increased cardiopulmonary disease risk in a community-based sample with chemical odor intolerance: implications for women's health and health- care utilization. Arch Environ Health 1998;53:347-353.

Heuser, G. and Kent, P. 1996. Mast cell disorder after chemical exposure. 124th Annual Meeting of the American Public Health Association, New York NY, 20 November 1996.

Zeim, G, McTamney, J. Profile of patients with chemical injury and sensitivity. Environ Health Perspect. 1997 March; 105(Suppl 2): 417–436.

Fox RA, Joffres MR, Sampalli T, Casey J. The impact of a multidisciplinary, holistic approach to management of patients diagnosed with multiple chemical sensitivity on health care utilization costs: an observational study. J Altern Complement Med. 2007 Mar;13(2):223-9.

Gibson, P. Perceived treatment efficacy for conventional and alternative therapies reported by persons with multiple chemical sensitivity. Environmental Health Perspectives. 2003;111:12,1498–1504.

Key Words: multiple chemical sensitivity, chemical sensitivity, chemical sensitivities, multiple chemical sensitivities, MCS, EI, environmental illness, sick building syndrome, idiopathic environmental intolerance, fibromyalgia, chronic fatiuge, FM, CFS, mold illness, clinical ecology, alternative medicine, environmental medicine, neuropathy, encephalopathy, toxic, chemical

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